PARP2: poly(ADP-ribose) polymerase 2
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
3kcz chain A
3kcz chain B
3kjd chain A
3kjd chain B
4pjv chain A
4pjv chain B
4tvj chain A
4tvj chain B
4zzx chain A
4zzx chain B
4zzy chain A
5d5k chain B
5dsy chain A
5dsy chain B
5dsy chain C
5dsy chain D
6f1k chain A
6f5b chain A
6f5b chain B
6f5f chain A
6f5f chain B
6f5f chain C
6f5f chain D
6tx3 chain B
6usj chain U
6usj chain V
6x0l chain P
6x0l chain R
6x0m chain P
6x0m chain p
6x0n chain P
6x0n chain R
7aeo chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T28 KRVNNGNT APEDSSP 3 32 7 - - - - - 10 - - - - - - - - - - - 13 2 S33 GNTAPEDS SPAKKTR 7 225 69 - 9 8 7 2 - - 19 8 14 13 32 28 12 4 - - - - S34 NTAPEDSS PAKKTRR 9 631 46 - - - 28 25 99 - 61 35 53 47 13 11 48 12 33 13 89 18 S226 KKEESLKS PLKPESQ 1 15 - - - - - - - - - - - - - - - - - - 13 2
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
T28 KRVNNGNT APEDSSP - - - - - - - - - - - S33 GNTAPEDS SPAKKTR 2.4e-7 - - - - - - 2.4e-7 - - - S34 NTAPEDSS PAKKTRR 2.3e-11 - - 6.2e-9 - -0.92 4.6e-14 - 0.012 -0.088 0.02 S226 KKEESLKS PLKPESQ - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
T28
S33
S34
S226
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA T28 S33 S34 S226 protein RNA SCNV methylation CCRCC T28 S33 S34 S226 protein RNA SCNV methylation COAD T28 S33 S34 S226 protein RNA SCNV methylation GBM T28 S33 S34 S226 protein RNA SCNV methylation HNSCC T28 S33 S34 S226 protein RNA SCNV methylation LSCC T28 S33 S34 S226 protein RNA SCNV methylation LUAD T28 S33 S34 S226 protein RNA SCNV methylation OV T28 S33 S34 S226 protein RNA SCNV methylation PDAC T28 S33 S34 S226 protein RNA SCNV methylation UCEC T28 S33 S34 S226 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
T28
S33
S34
S226
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
T28
S33
S34
S226
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.