ARHGEF6: Rac/Cdc42 guanine nucleotide exchange factor 6
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1ujy chain A
1wyr chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S101 VNFSKVLS TLLAVNK 3 83 - - 4 4 - - - - - - 34 32 5 4 - - - - - - T102 NFSKVLST LLAVNKA 1 16 - - 8 8 - - - - - - - - - - - - - - - - S122 SERPCGRS SSLSAAN 2 15 - - - - 4 5 - - - - - - - - - - - - 6 - S123 ERPCGRSS SLSAANT 9 857 29 - 88 65 28 34 72 - 58 35 83 76 89 80 - - 11 3 88 18 S124 RPCGRSSS LSAANTS 10 685 29 - 8 8 38 51 99 - 11 7 40 35 57 52 22 4 89 37 89 9 S126 CGRSSSLS AANTSQT 7 70 - - 8 - 11 7 9 - - - 5 5 4 5 5 3 - - 5 3 T130 SSLSAANT SQTNPQG 2 15 6 - - - - - - - - - - - 5 4 - - - - - - S131 SLSAANTS QTNPQGA 1 24 - - - - - - - - - - - - 13 11 - - - - - - T133 SAANTSQT NPQGAVS 1 8 8 - - - - - - - - - - - - - - - - - - - S144 GAVSSTVS GLQRQSK 1 8 8 - - - - - - - - - - - - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S101 VNFSKVLS TLLAVNK -2.9e-19 - - - - - -2.9e-19 - - - - T102 NFSKVLST LLAVNKA - - - - - - - - - - - S122 SERPCGRS SSLSAAN - - - - - - - - - - - S123 ERPCGRSS SLSAANT -9.3e-19 - -1.5e-6 -2.7e-3 - -0.52 -3.7e-15 -4.4e-12 - - 0.12 S124 RPCGRSSS LSAANTS -1.3e-3 - - -0.006 - - -9.2e-3 -6.3e-3 - 0.094 - S126 CGRSSSLS AANTSQT - - - - - - - - - - - T130 SSLSAANT SQTNPQG - - - - - - - - - - - S131 SLSAANTS QTNPQGA - - - - - - - - - - - T133 SAANTSQT NPQGAVS - - - - - - - - - - - S144 GAVSSTVS GLQRQSK - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S101
T102
S122
S123
S124
S126
T130
S131
T133
S144
S150
T152
Y188
S219
S220
S225
S552
S555
S560
S561
S565
S568
S569
S613
S622
S640
S678
S679
S684
S703
S768
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S101 T102 S122 S123 S124 S126 T130 S131 T133 S144 S150 T152 Y188 S219 S220 S225 S552 S555 S560 S561 S565 S568 S569 S613 S622 S640 S678 S679 S684 S703 S768 protein RNA SCNV methylation CCRCC S101 T102 S122 S123 S124 S126 T130 S131 T133 S144 S150 T152 Y188 S219 S220 S225 S552 S555 S560 S561 S565 S568 S569 S613 S622 S640 S678 S679 S684 S703 S768 protein RNA SCNV methylation COAD S101 T102 S122 S123 S124 S126 T130 S131 T133 S144 S150 T152 Y188 S219 S220 S225 S552 S555 S560 S561 S565 S568 S569 S613 S622 S640 S678 S679 S684 S703 S768 protein RNA SCNV methylation GBM S101 T102 S122 S123 S124 S126 T130 S131 T133 S144 S150 T152 Y188 S219 S220 S225 S552 S555 S560 S561 S565 S568 S569 S613 S622 S640 S678 S679 S684 S703 S768 protein RNA SCNV methylation HNSCC S101 T102 S122 S123 S124 S126 T130 S131 T133 S144 S150 T152 Y188 S219 S220 S225 S552 S555 S560 S561 S565 S568 S569 S613 S622 S640 S678 S679 S684 S703 S768 protein RNA SCNV methylation LSCC S101 T102 S122 S123 S124 S126 T130 S131 T133 S144 S150 T152 Y188 S219 S220 S225 S552 S555 S560 S561 S565 S568 S569 S613 S622 S640 S678 S679 S684 S703 S768 protein RNA SCNV methylation LUAD S101 T102 S122 S123 S124 S126 T130 S131 T133 S144 S150 T152 Y188 S219 S220 S225 S552 S555 S560 S561 S565 S568 S569 S613 S622 S640 S678 S679 S684 S703 S768 protein RNA SCNV methylation OV S101 T102 S122 S123 S124 S126 T130 S131 T133 S144 S150 T152 Y188 S219 S220 S225 S552 S555 S560 S561 S565 S568 S569 S613 S622 S640 S678 S679 S684 S703 S768 protein RNA SCNV methylation PDAC S101 T102 S122 S123 S124 S126 T130 S131 T133 S144 S150 T152 Y188 S219 S220 S225 S552 S555 S560 S561 S565 S568 S569 S613 S622 S640 S678 S679 S684 S703 S768 protein RNA SCNV methylation UCEC S101 T102 S122 S123 S124 S126 T130 S131 T133 S144 S150 T152 Y188 S219 S220 S225 S552 S555 S560 S561 S565 S568 S569 S613 S622 S640 S678 S679 S684 S703 S768 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S101
T102
S122
S123
S124
S126
T130
S131
T133
S144
S150
T152
Y188
S219
S220
S225
S552
S555
S560
S561
S565
S568
S569
S613
S622
S640
S678
S679
S684
S703
S768
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S101
T102
S122
S123
S124
S126
T130
S131
T133
S144
S150
T152
Y188
S219
S220
S225
S552
S555
S560
S561
S565
S568
S569
S613
S622
S640
S678
S679
S684
S703
S768
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.