RAF1: Raf-1 proto-oncogene, serine/threonine kinase
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1c1y chain B
1faq chain A
1far chain A
1gua chain B
1rfa chain A
3cu8 chain P
3cu8 chain Q
3iqj chain P
3iqu chain P
3iqv chain P
3kuc chain B
3kud chain B
3nkx chain P
3nkx chain Q
3o8i chain B
3omv chain A
3omv chain B
4fj3 chain P
4g0n chain B
4g3x chain B
4iea chain P
4ihl chain P
6ntc chain B
6ntd chain B
6pts chain D
6ptw chain D
6vjj chain B
6xgu chain B
6xgv chain B
6xha chain B
6xhb chain B
6xi7 chain B
7jhp chain C
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S12 QGAWKTIS NGFGFKD 8 321 - - 45 27 - - 9 - 7 3 40 36 26 26 35 7 3 2 42 13 S29 FDGSSCIS PTIVQQF 9 1245 - - 99 76 27 27 99 - 95 56 106 99 110 100 83 18 103 43 86 18 S43 FGYQRRAS DDGKLTD 4 230 - - - - 97 100 - - - - - - - - 14 2 7 4 6 - S177 YKFHEHCS TKVPTMC 1 8 - - 4 4 - - - - - - - - - - - - - - - - S233 VSSQHRYS TPHAFTF 8 576 - - - - 56 69 90 - 28 15 25 23 28 24 54 13 46 18 80 7 T234 SSQHRYST PHAFTFN 4 49 - - - - 4 5 17 - - - - - 8 8 - - 5 2 - - T242 PHAFTFNT SSPSSEG 2 36 - - - - - - - - 6 3 14 13 - - - - - - - - S243 HAFTFNTS SPSSEGS 1 9 - - - - - - 9 - - - - - - - - - - - - - S244 AFTFNTSS PSSEGSL 3 84 - - - - - - 18 - - - - - - - 22 4 - - 24 16 S257 SLSQRQRS TSTPNVH 1 9 - - - - - - 9 - - - - - - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S12 QGAWKTIS NGFGFKD -4.2e-4 - -0.14 - - - -1.3e-4 0.5 - - -0.015 S29 FDGSSCIS PTIVQQF -9.2e-8 - 0.011 -0.41 - -2.6e-18 -1e-14 -2.6e-3 -0.88 3.2e-4 -0.42 S43 FGYQRRAS DDGKLTD -5.8e-6 - - -5.8e-6 - - - - - - - S177 YKFHEHCS TKVPTMC - - - - - - - - - - - S233 VSSQHRYS TPHAFTF 0.68 - - -0.66 - -0.23 -0.3 -0.025 3.8e-3 2.4e-3 - T234 SSQHRYST PHAFTFN - - - - - - - - - - - T242 PHAFTFNT SSPSSEG - - - - - - - - - - - S243 HAFTFNTS SPSSEGS - - - - - - - - - - - S244 AFTFNTSS PSSEGSL 5.0e-6 - - - - - - - - - 5.0e-6 S257 SLSQRQRS TSTPNVH - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S12
S29
S43
S177
S233
T234
T242
S243
S244
S257
S259
T260
S285
S287
S289
S291
S294
S295
S296
S301
T310
S338
S497
S612
T638
T640
T641
S642
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S12 S29 S43 S177 S233 T234 T242 S243 S244 S257 S259 T260 S285 S287 S289 S291 S294 S295 S296 S301 T310 S338 S497 S612 T638 T640 T641 S642 protein RNA SCNV methylation CCRCC S12 S29 S43 S177 S233 T234 T242 S243 S244 S257 S259 T260 S285 S287 S289 S291 S294 S295 S296 S301 T310 S338 S497 S612 T638 T640 T641 S642 protein RNA SCNV methylation COAD S12 S29 S43 S177 S233 T234 T242 S243 S244 S257 S259 T260 S285 S287 S289 S291 S294 S295 S296 S301 T310 S338 S497 S612 T638 T640 T641 S642 protein RNA SCNV methylation GBM S12 S29 S43 S177 S233 T234 T242 S243 S244 S257 S259 T260 S285 S287 S289 S291 S294 S295 S296 S301 T310 S338 S497 S612 T638 T640 T641 S642 protein RNA SCNV methylation HNSCC S12 S29 S43 S177 S233 T234 T242 S243 S244 S257 S259 T260 S285 S287 S289 S291 S294 S295 S296 S301 T310 S338 S497 S612 T638 T640 T641 S642 protein RNA SCNV methylation LSCC S12 S29 S43 S177 S233 T234 T242 S243 S244 S257 S259 T260 S285 S287 S289 S291 S294 S295 S296 S301 T310 S338 S497 S612 T638 T640 T641 S642 protein RNA SCNV methylation LUAD S12 S29 S43 S177 S233 T234 T242 S243 S244 S257 S259 T260 S285 S287 S289 S291 S294 S295 S296 S301 T310 S338 S497 S612 T638 T640 T641 S642 protein RNA SCNV methylation OV S12 S29 S43 S177 S233 T234 T242 S243 S244 S257 S259 T260 S285 S287 S289 S291 S294 S295 S296 S301 T310 S338 S497 S612 T638 T640 T641 S642 protein RNA SCNV methylation PDAC S12 S29 S43 S177 S233 T234 T242 S243 S244 S257 S259 T260 S285 S287 S289 S291 S294 S295 S296 S301 T310 S338 S497 S612 T638 T640 T641 S642 protein RNA SCNV methylation UCEC S12 S29 S43 S177 S233 T234 T242 S243 S244 S257 S259 T260 S285 S287 S289 S291 S294 S295 S296 S301 T310 S338 S497 S612 T638 T640 T641 S642 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S12
S29
S43
S177
S233
T234
T242
S243
S244
S257
S259
T260
S285
S287
S289
S291
S294
S295
S296
S301
T310
S338
S497
S612
T638
T640
T641
S642
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S12
S29
S43
S177
S233
T234
T242
S243
S244
S257
S259
T260
S285
S287
S289
S291
S294
S295
S296
S301
T310
S338
S497
S612
T638
T640
T641
S642
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.