TRIM28: tripartite motif containing 28
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1fp0 chain A
2ro1 chain A
2yvr chain A
2yvr chain B
6h3a chain A
6h3a chain F
6i9h chain A
6qaj chain A
6qaj chain B
6qu1 chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S4 ____MAAS AAAASAA 1 4 - - - - - - - - - - - - - - - - - - 4 - S9 AASAAAAS AAAASAA 3 43 - - 4 4 - - - - - - - - 5 4 - - - - 23 3 S14 AASAAAAS AASGSPG 4 63 8 - 4 4 - - - - - - - - 5 4 - - - - 35 3 S17 AAAASAAS GSPGPGE 4 45 17 - 4 4 - - - - - - - - - - - - 8 4 8 - S19 AASAASGS PGPGEGS 3 31 - - 4 4 - - - - - - - - - - - - 8 4 11 - S33 SAGGEKRS TAPSAAA 3 40 - - - - - - 10 - 6 3 - - - - - - 17 4 - - T34 AGGEKRST APSAAAS 1 21 - - - - - - - - - - - - - - - - 17 4 - - S37 EKRSTAPS AAASASA 1 21 - - - - - - - - - - - - - - - - 17 4 - - S41 TAPSAAAS ASASAAA 1 9 - - - - - - 9 - - - - - - - - - - - - - S43 PSAAASAS ASAAASS 2 8 6 - - - - - - - - - - - - - 2 - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S4 ____MAAS AAAASAA - - - - - - - - - - - S9 AASAAAAS AAAASAA - - - - - - - - - - - S14 AASAAAAS AASGSPG - - - - - - - - - - - S17 AAAASAAS GSPGPGE - - - - - - - - - - - S19 AASAASGS PGPGEGS - - - - - - - - - - - S33 SAGGEKRS TAPSAAA - - - - - - - - - - - T34 AGGEKRST APSAAAS - - - - - - - - - - - S37 EKRSTAPS AAASASA - - - - - - - - - - - S41 TAPSAAAS ASASAAA - - - - - - - - - - - S43 PSAAASAS ASAAASS - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S4
S9
S14
S17
S19
S33
T34
S37
S41
S43
S45
S49
S50
S89
S102
T113
S138
S164
S170
S194
S223
S258
S285
S350
S401
T415
S417
S437
S439
S440
Y449
S453
S471
S473
S489
T498
S501
S512
T513
T514
Y517
T536
T541
T567
S594
S596
S598
T599
S600
S601
T611
S612
T620
S624
S681
S683
S689
S697
S752
Y755
S756
S757
S784
S816
S823
S824
S828
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S4 S9 S14 S17 S19 S33 T34 S37 S41 S43 S45 S49 S50 S89 S102 T113 S138 S164 S170 S194 S223 S258 S285 S350 S401 T415 S417 S437 S439 S440 Y449 S453 S471 S473 S489 T498 S501 S512 T513 T514 Y517 T536 T541 T567 S594 S596 S598 T599 S600 S601 T611 S612 T620 S624 S681 S683 S689 S697 S752 Y755 S756 S757 S784 S816 S823 S824 S828 protein RNA SCNV methylation CCRCC S4 S9 S14 S17 S19 S33 T34 S37 S41 S43 S45 S49 S50 S89 S102 T113 S138 S164 S170 S194 S223 S258 S285 S350 S401 T415 S417 S437 S439 S440 Y449 S453 S471 S473 S489 T498 S501 S512 T513 T514 Y517 T536 T541 T567 S594 S596 S598 T599 S600 S601 T611 S612 T620 S624 S681 S683 S689 S697 S752 Y755 S756 S757 S784 S816 S823 S824 S828 protein RNA SCNV methylation COAD S4 S9 S14 S17 S19 S33 T34 S37 S41 S43 S45 S49 S50 S89 S102 T113 S138 S164 S170 S194 S223 S258 S285 S350 S401 T415 S417 S437 S439 S440 Y449 S453 S471 S473 S489 T498 S501 S512 T513 T514 Y517 T536 T541 T567 S594 S596 S598 T599 S600 S601 T611 S612 T620 S624 S681 S683 S689 S697 S752 Y755 S756 S757 S784 S816 S823 S824 S828 protein RNA SCNV methylation GBM S4 S9 S14 S17 S19 S33 T34 S37 S41 S43 S45 S49 S50 S89 S102 T113 S138 S164 S170 S194 S223 S258 S285 S350 S401 T415 S417 S437 S439 S440 Y449 S453 S471 S473 S489 T498 S501 S512 T513 T514 Y517 T536 T541 T567 S594 S596 S598 T599 S600 S601 T611 S612 T620 S624 S681 S683 S689 S697 S752 Y755 S756 S757 S784 S816 S823 S824 S828 protein RNA SCNV methylation HNSCC S4 S9 S14 S17 S19 S33 T34 S37 S41 S43 S45 S49 S50 S89 S102 T113 S138 S164 S170 S194 S223 S258 S285 S350 S401 T415 S417 S437 S439 S440 Y449 S453 S471 S473 S489 T498 S501 S512 T513 T514 Y517 T536 T541 T567 S594 S596 S598 T599 S600 S601 T611 S612 T620 S624 S681 S683 S689 S697 S752 Y755 S756 S757 S784 S816 S823 S824 S828 protein RNA SCNV methylation LSCC S4 S9 S14 S17 S19 S33 T34 S37 S41 S43 S45 S49 S50 S89 S102 T113 S138 S164 S170 S194 S223 S258 S285 S350 S401 T415 S417 S437 S439 S440 Y449 S453 S471 S473 S489 T498 S501 S512 T513 T514 Y517 T536 T541 T567 S594 S596 S598 T599 S600 S601 T611 S612 T620 S624 S681 S683 S689 S697 S752 Y755 S756 S757 S784 S816 S823 S824 S828 protein RNA SCNV methylation LUAD S4 S9 S14 S17 S19 S33 T34 S37 S41 S43 S45 S49 S50 S89 S102 T113 S138 S164 S170 S194 S223 S258 S285 S350 S401 T415 S417 S437 S439 S440 Y449 S453 S471 S473 S489 T498 S501 S512 T513 T514 Y517 T536 T541 T567 S594 S596 S598 T599 S600 S601 T611 S612 T620 S624 S681 S683 S689 S697 S752 Y755 S756 S757 S784 S816 S823 S824 S828 protein RNA SCNV methylation OV S4 S9 S14 S17 S19 S33 T34 S37 S41 S43 S45 S49 S50 S89 S102 T113 S138 S164 S170 S194 S223 S258 S285 S350 S401 T415 S417 S437 S439 S440 Y449 S453 S471 S473 S489 T498 S501 S512 T513 T514 Y517 T536 T541 T567 S594 S596 S598 T599 S600 S601 T611 S612 T620 S624 S681 S683 S689 S697 S752 Y755 S756 S757 S784 S816 S823 S824 S828 protein RNA SCNV methylation PDAC S4 S9 S14 S17 S19 S33 T34 S37 S41 S43 S45 S49 S50 S89 S102 T113 S138 S164 S170 S194 S223 S258 S285 S350 S401 T415 S417 S437 S439 S440 Y449 S453 S471 S473 S489 T498 S501 S512 T513 T514 Y517 T536 T541 T567 S594 S596 S598 T599 S600 S601 T611 S612 T620 S624 S681 S683 S689 S697 S752 Y755 S756 S757 S784 S816 S823 S824 S828 protein RNA SCNV methylation UCEC S4 S9 S14 S17 S19 S33 T34 S37 S41 S43 S45 S49 S50 S89 S102 T113 S138 S164 S170 S194 S223 S258 S285 S350 S401 T415 S417 S437 S439 S440 Y449 S453 S471 S473 S489 T498 S501 S512 T513 T514 Y517 T536 T541 T567 S594 S596 S598 T599 S600 S601 T611 S612 T620 S624 S681 S683 S689 S697 S752 Y755 S756 S757 S784 S816 S823 S824 S828 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S4
S9
S14
S17
S19
S33
T34
S37
S41
S43
S45
S49
S50
S89
S102
T113
S138
S164
S170
S194
S223
S258
S285
S350
S401
T415
S417
S437
S439
S440
Y449
S453
S471
S473
S489
T498
S501
S512
T513
T514
Y517
T536
T541
T567
S594
S596
S598
T599
S600
S601
T611
S612
T620
S624
S681
S683
S689
S697
S752
Y755
S756
S757
S784
S816
S823
S824
S828
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S4
S9
S14
S17
S19
S33
T34
S37
S41
S43
S45
S49
S50
S89
S102
T113
S138
S164
S170
S194
S223
S258
S285
S350
S401
T415
S417
S437
S439
S440
Y449
S453
S471
S473
S489
T498
S501
S512
T513
T514
Y517
T536
T541
T567
S594
S596
S598
T599
S600
S601
T611
S612
T620
S624
S681
S683
S689
S697
S752
Y755
S756
S757
S784
S816
S823
S824
S828
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.