Protein: ENSP00000253237
Gene: GRWD1

LinkedOmicsKB © 2022-2023 Zhang Lab

GRWD1:
glutamate rich WD repeat containing 1

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T10ARKGRRRTCETGEPM8181--421736-199191889--512815
T13GRRRTCETGEPMEAE2199---------55--------
S21GEPMEAESGDTSSEG2178-------72----------
T24MEAESGDTSSEGPAQ110----------55--------
S26AESGDTSSEGPAQVY244------9-----------314
T114RMHNLHGTKPPPSEG19----45--------------
S119HGTKPPPSEGSDEEE872496-1210404973---1039310292--64395
S122KPPPSEGSDEEEEEE83338-12109918---10910292--64395
S263PFVGHTRSVEDLQWS452------9---151444----6-
S344LRQFKSGSPVATFKQ1060564-122151262-6740403725245193088918
Showing 1 to 10 of 10 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
T10ARKGRRRTCETGEPM-0.43----------0.43
T13GRRRTCETGEPMEAE-----------
S21GEPMEAESGDTSSEG-----------
T24MEAESGDTSSEGPAQ-----------
S26AESGDTSSEGPAQVY-----------
T114RMHNLHGTKPPPSEG-----------
S119HGTKPPPSEGSDEEE3e-15--3.1e-3--2.3e-92.1e-6---
S122KPPPSEGSDEEEEEE2.1e-6------2.1e-6---
S263PFVGHTRSVEDLQWS-----------
S344LRQFKSGSPVATFKQ4.1e-34----1.9e-81.9e-191.9e-6--7.4e-7
Showing 1 to 10 of 10 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_MYC_TARGETS_V2S3444.2e-187.1e-5-0.670.0140.0117.1e-101.5e-39.7e-30.20.161.8e-5
HALLMARK_E2F_TARGETSS3446.4e-182.3e-30.23.9e-40.132.3e-51.1e-34.2e-30.0540.267.9e-6
KINASE-PSP_CK2A1/CSNK2A1S1191.6e-174.1e-34.1e-31.9e-31.8e-5-1.7e-55.2e-4--0.1
HALLMARK_G2M_CHECKPOINTS3441.8e-173.4e-30.119.0e-40.236.4e-64.3e-31.7e-30.10.254.4e-6
KINASE-PSP_CDK1S3446e-154.4e-5-0.50.0380.0736.4e-50.020.0120.0250.0392.0e-5
KINASE-PSP_CDK2S3441.6e-131.3e-4-0.722.7e-30.668.9e-60.354.9e-30.230.0484.2e-7
KINASE-PSP_CK2A1/CSNK2A1S3447.7e-120.131.9e-41.4e-32.7e-47.9e-64.3e-40.33-0.0020.160.021
HALLMARK_MYC_TARGETS_V1S3441.2e-111.7e-30.970.0240.0851.3e-54.9e-30.120.170.128.9e-3
HALLMARK_MITOTIC_SPINDLES3448.2e-110.0670.010.240.124.4e-30.0180.0370.290.0363.1e-3
HALLMARK_MTORC1_SIGNALINGS3441.2e-100.054-0.437.4e-42.2e-57.3e-30.544.8e-30.0820.374.3e-3
Showing 1 to 10 of 2580 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAT10T13S21T24S26T114S119S122S263S344proteinRNASCNVmethylationCCRCCT10T13S21T24S26T114S119S122S263S344proteinRNASCNVmethylationCOADT10T13S21T24S26T114S119S122S263S344proteinRNASCNVmethylationGBMT10T13S21T24S26T114S119S122S263S344proteinRNASCNVmethylationHNSCCT10T13S21T24S26T114S119S122S263S344proteinRNASCNVmethylationLSCCT10T13S21T24S26T114S119S122S263S344proteinRNASCNVmethylationLUADT10T13S21T24S26T114S119S122S263S344proteinRNASCNVmethylationOVT10T13S21T24S26T114S119S122S263S344proteinRNASCNVmethylationPDACT10T13S21T24S26T114S119S122S263S344proteinRNASCNVmethylationUCECT10T13S21T24S26T114S119S122S263S344proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.