RPA1: replication protein A1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1ewi chain A
1fgu chain A
1fgu chain B
1jmc chain A
1l1o chain C
1l1o chain F
2b29 chain A
2b3g chain A
4ijh chain A
4ijl chain A
4ipc chain A
4ipd chain A
4ipg chain A
4iph chain A
4luo chain A
4luv chain A
4luz chain A
4lw1 chain A
4lwc chain A
4nb3 chain A
4nb3 chain B
4o0a chain A
4r4c chain A
4r4i chain A
4r4o chain A
4r4q chain A
4r4t chain A
5e7n chain A
5eay chain A
5eay chain B
5eay chain C
5eay chain D
5n85 chain A
5n8a chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S38 RPITTGNS PPRYRLL 10 1305 95 - 103 80 56 68 99 - 101 60 103 94 106 97 61 14 59 26 65 18 S135 APPAPAAS PAASSRP 9 999 95 - 87 72 - - 63 - 83 51 94 85 94 84 26 6 37 15 89 18 S140 AASPAASS RPQPQNG 1 8 - - - - - - - - - - - - - - - - - - 5 3 S149 PQPQNGSS GMGSTVS 1 9 - - - - - - - - - - - - 5 4 - - - - - - S153 NGSSGMGS TVSKAYG 1 27 - - - - - - - - - - 15 12 - - - - - - - - S172 FGKAAGPS LSHTSGG 1 17 - - - - - - - - - - - - - - 13 4 - - - - S174 KAAGPSLS HTSGGTQ 3 74 14 - - - - - - - - - - - 9 8 35 8 - - - - S177 GPSLSHTS GGTQSKV 1 9 - - - - - - - - - - - - 5 4 - - - - - - T180 LSHTSGGT QSKVVPI 1 34 - - - - - - - - - - - - - - 29 5 - - - - T191 VVPIASLT PYQSKWT 2 40 30 - - - - - - - - - 5 5 - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S38 RPITTGNS PPRYRLL 0.006 - 1.9e-6 -0.84 - -1.5e-16 3.4e-9 6.8e-7 0.16 -0.39 -0.99 S135 APPAPAAS PAASSRP 1.2e-16 - 7.4e-22 - - -0.12 6.6e-4 8.7e-6 - 0.1 5.9e-3 S140 AASPAASS RPQPQNG - - - - - - - - - - - S149 PQPQNGSS GMGSTVS - - - - - - - - - - - S153 NGSSGMGS TVSKAYG - - - - - - - - - - - S172 FGKAAGPS LSHTSGG - - - - - - - - - - - S174 KAAGPSLS HTSGGTQ - - - - - - - - - - - S177 GPSLSHTS GGTQSKV - - - - - - - - - - - T180 LSHTSGGT QSKVVPI - - - - - - - - - - - T191 VVPIASLT PYQSKWT - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S38
S135
S140
S149
S153
S172
S174
S177
T180
T191
S195
S215
S315
S384
S390
S392
S395
S396
S426
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S38 S135 S140 S149 S153 S172 S174 S177 T180 T191 S195 S215 S315 S384 S390 S392 S395 S396 S426 protein RNA SCNV methylation CCRCC S38 S135 S140 S149 S153 S172 S174 S177 T180 T191 S195 S215 S315 S384 S390 S392 S395 S396 S426 protein RNA SCNV methylation COAD S38 S135 S140 S149 S153 S172 S174 S177 T180 T191 S195 S215 S315 S384 S390 S392 S395 S396 S426 protein RNA SCNV methylation GBM S38 S135 S140 S149 S153 S172 S174 S177 T180 T191 S195 S215 S315 S384 S390 S392 S395 S396 S426 protein RNA SCNV methylation HNSCC S38 S135 S140 S149 S153 S172 S174 S177 T180 T191 S195 S215 S315 S384 S390 S392 S395 S396 S426 protein RNA SCNV methylation LSCC S38 S135 S140 S149 S153 S172 S174 S177 T180 T191 S195 S215 S315 S384 S390 S392 S395 S396 S426 protein RNA SCNV methylation LUAD S38 S135 S140 S149 S153 S172 S174 S177 T180 T191 S195 S215 S315 S384 S390 S392 S395 S396 S426 protein RNA SCNV methylation OV S38 S135 S140 S149 S153 S172 S174 S177 T180 T191 S195 S215 S315 S384 S390 S392 S395 S396 S426 protein RNA SCNV methylation PDAC S38 S135 S140 S149 S153 S172 S174 S177 T180 T191 S195 S215 S315 S384 S390 S392 S395 S396 S426 protein RNA SCNV methylation UCEC S38 S135 S140 S149 S153 S172 S174 S177 T180 T191 S195 S215 S315 S384 S390 S392 S395 S396 S426 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S38
S135
S140
S149
S153
S172
S174
S177
T180
T191
S195
S215
S315
S384
S390
S392
S395
S396
S426
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S38
S135
S140
S149
S153
S172
S174
S177
T180
T191
S195
S215
S315
S384
S390
S392
S395
S396
S426
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.