Protein: ENSP00000257430
Gene: APC

LinkedOmicsKB © 2022-2023 Zhang Lab

APC:
APC regulator of WNT signaling pathway

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S54VLKQLQGSIEDEAMA19------9-------------
S98MSLRSYGSREGSVSS4125--211281026---2523--------
S107EGSVSSRSGECSPVP2247-----------------134
S111SSRSGECSPVPMGSF1069635-29174599-27175045716429562249518
S117CSPVPMGSFPRRGFV224------18-----------6-
S130FVNGSRESTGYLEEL7280--2111--27-32211010--15361272616
T131VNGSRESTGYLEELE219----------5554------
Y133GSRESTGYLEELEKE19------------45------
S246ATEAERSSQNKHETG336------9---------42129
S254QNKHETGSHDAERQN431----5310---54--4-----
Showing 1 to 10 of 177 rows
102550100
rows per page

Tumor and normal comparison

Loading, please wait
Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S54VLKQLQGSIEDEAMA-----------
S98MSLRSYGSREGSVSS-0.46-0.01----2.8e-4----
S107EGSVSSRSGECSPVP-----------
S111SSRSGECSPVPMGSF-8.5e-3-0.91--0.62-0.018-0.017--1.3e-50.041
S117CSPVPMGSFPRRGFV-----------
S130FVNGSRESTGYLEEL-1.7e-5-5.1e-4---5.6e-6----3.2e-7-0.015
T131VNGSRESTGYLEELE-----------
Y133GSRESTGYLEELEKE-----------
S246ATEAERSSQNKHETG-----------
S254QNKHETGSHDAERQN-----------
Showing 1 to 10 of 177 rows
102550100
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

Loading, please wait
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

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

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

Loading, please wait
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

Loading, please wait
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.