Protein: ENSP00000257904

CDK4:: cyclin dependent kinase 4

Lollipop plot

Phosphosites location and occurrence

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* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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				BRCA		CCRCC		COAD		GBM		HNSCC		LSCC		LUAD		OV		PDAC		UCEC
Site	Sequence	Cohorts	Total	T	N	T	N	T	N	T	N	T	N	T	N	T	N	T	N	T	N	T	N
T172	YSYQMALTPVVVTLW	1	26	-	-	-	-	-	-	26	-	-	-	-	-	-	-	-	-	-	-	-	-

Showing 1 to 1 of 1 rows

Tumor and normal comparison

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Site	Sequence	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
T172	YSYQMALTPVVVTLW	-	-	-	-	-	-	-	-	-	-	-

Showing 1 to 1 of 1 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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			Signed p-values
Phenotype	Site	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
PERT-P100-DIA_SEMAGACESTAT	T172	0.015	-	-	-	0.015	-	-	-	-	-	-
KINASE-PSP_CK2A1/CSNK2A1	T172	0.018	-	-	-	0.018	-	-	-	-	-	-
xcell: Myeloid dendritic cell	T172	0.033	-	-	-	0.033	-	-	-	-	-	-
xcell: T cell gamma delta	T172	0.037	-	-	-	0.037	-	-	-	-	-	-
xcell: Monocyte	T172	0.04	-	-	-	0.04	-	-	-	-	-	-
xcell: Granulocyte-monocyte progenitor	T172	0.063	-	-	-	0.063	-	-	-	-	-	-
xcell: stroma score	T172	0.064	-	-	-	0.064	-	-	-	-	-	-
HALLMARK_ALLOGRAFT_REJECTION	T172	0.064	-	-	-	0.064	-	-	-	-	-	-
HALLMARK_IL6_JAK_STAT3_SIGNALING	T172	0.086	-	-	-	0.086	-	-	-	-	-	-
xcell: microenvironment score	T172	0.086	-	-	-	0.086	-	-	-	-	-	-

Showing 1 to 10 of 258 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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			Signed p-values
Kinase	Site	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
AURKA	T172	1.3e-3	-	-	-	1.3e-3	-	-	-	-	-	-
PBK	T172	5.4e-3	-	-	-	5.4e-3	-	-	-	-	-	-
PRKG1	T172	0.018	-	-	-	0.018	-	-	-	-	-	-
BUB1	T172	0.021	-	-	-	0.021	-	-	-	-	-	-
HCK	T172	0.029	-	-	-	0.029	-	-	-	-	-	-
IRAK3	T172	0.04	-	-	-	0.04	-	-	-	-	-	-
FES	T172	0.045	-	-	-	0.045	-	-	-	-	-	-
AURKB	T172	0.046	-	-	-	0.046	-	-	-	-	-	-
STK16	T172	0.057	-	-	-	0.057	-	-	-	-	-	-
NME1	T172	0.058	-	-	-	0.058	-	-	-	-	-	-

Showing 1 to 10 of 538 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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			Signed p-values
Phosphatase	Site	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
PTPN13	T172	-2.9e-3	-	-	-	-2.9e-3	-	-	-	-	-	-
PPM1A	T172	-0.014	-	-	-	-0.014	-	-	-	-	-	-
MTMR2	T172	-0.019	-	-	-	-0.019	-	-	-	-	-	-
INPP5E	T172	-0.03	-	-	-	-0.03	-	-	-	-	-	-
PDXP	T172	-0.033	-	-	-	-0.033	-	-	-	-	-	-
PTPRS	T172	-0.051	-	-	-	-0.051	-	-	-	-	-	-
EPM2A	T172	-0.051	-	-	-	-0.051	-	-	-	-	-	-
PTPRZ1	T172	-0.052	-	-	-	-0.052	-	-	-	-	-	-
IMPA1	T172	-0.059	-	-	-	-0.059	-	-	-	-	-	-
PTPRA	T172	-0.061	-	-	-	-0.061	-	-	-	-	-	-

Showing 1 to 10 of 240 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Protein: ENSP00000257904Gene: CDK4

Lollipop plot

Structure

Phosphosite detection coverage

Tumor and normal comparison

Phenotype and mutation association

Cis-association

Kinase association

Phosphatase association

Protein: ENSP00000257904
Gene: CDK4