DOCK10: dedicator of cytokinesis 10
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
6tky chain A
6tky chain B
6tkz chain A
6tkz chain B
6tm1 chain B
6tm1 chain C
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S12 RTRRFTRS LLRPGQA 10 1007 122 - 90 69 39 41 99 - 33 18 69 62 79 72 39 10 63 26 61 15 S25 QAAELRHS AASAAAV 3 44 - - - - - - 18 - - - 9 8 - - 8 1 - - - - S151 PEKLPSHS FEIDHED 1 90 - - - - - - 90 - - - - - - - - - - - - - T165 DADKDEDT TSHSSSK 2 19 9 - - - - - - - - - 5 5 - - - - - - - - T166 ADKDEDTT SHSSSKG 4 49 - - 4 4 - - - - 4 4 14 14 - - - - 4 1 - - S167 DKDEDTTS HSSSKGG 5 69 8 - 4 4 - - 9 - - - 19 19 - - - - 5 1 - - S169 DEDTTSHS SSKGGGG 1 9 - - - - - - - - - - 5 4 - - - - - - - - S170 EDTTSHSS SKGGGGA 1 18 - - - - - - 18 - - - - - - - - - - - - - T196 YKGNFNST VNNTVTV 6 191 23 - 4 2 - - 45 - - - 30 28 26 25 7 1 - - - - S292 LNRILQIS PEGPLQG 1 90 - - - - - - 90 - - - - - - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S12 RTRRFTRS LLRPGQA 1.8e-4 - 1.8e-5 0.52 - 0.17 -6.6e-4 2.7e-6 -0.7 9.2e-6 -0.28 S25 QAAELRHS AASAAAV - - - - - - - - - - - S151 PEKLPSHS FEIDHED - - - - - - - - - - - T165 DADKDEDT TSHSSSK - - - - - - - - - - - T166 ADKDEDTT SHSSSKG - - - - - - - - - - - S167 DKDEDTTS HSSSKGG - - - - - - - - - - - S169 DEDTTSHS SSKGGGG - - - - - - - - - - - S170 EDTTSHSS SKGGGGA - - - - - - - - - - - T196 YKGNFNST VNNTVTV -6.1e-18 - - - - - -1.9e-13 -1.3e-6 - - - S292 LNRILQIS PEGPLQG - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S12
S25
S151
T165
T166
S167
S169
S170
T196
S292
S302
T303
S877
T1125
T1228
T1231
S1232
S1236
S1241
T1242
S1257
S1261
S1289
S1292
S1295
S1318
S1322
T1406
T1440
S1451
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S12 S25 S151 T165 T166 S167 S169 S170 T196 S292 S302 T303 S877 T1125 T1228 T1231 S1232 S1236 S1241 T1242 S1257 S1261 S1289 S1292 S1295 S1318 S1322 T1406 T1440 S1451 protein RNA SCNV methylation CCRCC S12 S25 S151 T165 T166 S167 S169 S170 T196 S292 S302 T303 S877 T1125 T1228 T1231 S1232 S1236 S1241 T1242 S1257 S1261 S1289 S1292 S1295 S1318 S1322 T1406 T1440 S1451 protein RNA SCNV methylation COAD S12 S25 S151 T165 T166 S167 S169 S170 T196 S292 S302 T303 S877 T1125 T1228 T1231 S1232 S1236 S1241 T1242 S1257 S1261 S1289 S1292 S1295 S1318 S1322 T1406 T1440 S1451 protein RNA SCNV methylation GBM S12 S25 S151 T165 T166 S167 S169 S170 T196 S292 S302 T303 S877 T1125 T1228 T1231 S1232 S1236 S1241 T1242 S1257 S1261 S1289 S1292 S1295 S1318 S1322 T1406 T1440 S1451 protein RNA SCNV methylation HNSCC S12 S25 S151 T165 T166 S167 S169 S170 T196 S292 S302 T303 S877 T1125 T1228 T1231 S1232 S1236 S1241 T1242 S1257 S1261 S1289 S1292 S1295 S1318 S1322 T1406 T1440 S1451 protein RNA SCNV methylation LSCC S12 S25 S151 T165 T166 S167 S169 S170 T196 S292 S302 T303 S877 T1125 T1228 T1231 S1232 S1236 S1241 T1242 S1257 S1261 S1289 S1292 S1295 S1318 S1322 T1406 T1440 S1451 protein RNA SCNV methylation LUAD S12 S25 S151 T165 T166 S167 S169 S170 T196 S292 S302 T303 S877 T1125 T1228 T1231 S1232 S1236 S1241 T1242 S1257 S1261 S1289 S1292 S1295 S1318 S1322 T1406 T1440 S1451 protein RNA SCNV methylation OV S12 S25 S151 T165 T166 S167 S169 S170 T196 S292 S302 T303 S877 T1125 T1228 T1231 S1232 S1236 S1241 T1242 S1257 S1261 S1289 S1292 S1295 S1318 S1322 T1406 T1440 S1451 protein RNA SCNV methylation PDAC S12 S25 S151 T165 T166 S167 S169 S170 T196 S292 S302 T303 S877 T1125 T1228 T1231 S1232 S1236 S1241 T1242 S1257 S1261 S1289 S1292 S1295 S1318 S1322 T1406 T1440 S1451 protein RNA SCNV methylation UCEC S12 S25 S151 T165 T166 S167 S169 S170 T196 S292 S302 T303 S877 T1125 T1228 T1231 S1232 S1236 S1241 T1242 S1257 S1261 S1289 S1292 S1295 S1318 S1322 T1406 T1440 S1451 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S12
S25
S151
T165
T166
S167
S169
S170
T196
S292
S302
T303
S877
T1125
T1228
T1231
S1232
S1236
S1241
T1242
S1257
S1261
S1289
S1292
S1295
S1318
S1322
T1406
T1440
S1451
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S12
S25
S151
T165
T166
S167
S169
S170
T196
S292
S302
T303
S877
T1125
T1228
T1231
S1232
S1236
S1241
T1242
S1257
S1261
S1289
S1292
S1295
S1318
S1322
T1406
T1440
S1451
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.