Protein: ENSP00000258962
Gene: SRSF1

LinkedOmicsKB © 2022-2023 Zhang Lab

SRSF1:
serine and arginine rich splicing factor 1

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S182LDNTKFRSHEGETAY19------9-------------
Y189SHEGETAYIRVKVDG218------9-----54------
S199VKVDGPRSPSYGRSR81320--103809710099-1086210899110101--100409518
S201VDGPRSPSYGRSRSR7709--58479710099---10101412--105449518
Y202DGPRSPSYGRSRSRS8537--885418-905263578880--3014164
S205RSPSYGRSRSRSRSR7449--493610862-442440364440----479
S225RSNSRSRSYSPRRSR118------18-------------
S227NSRSRSYSPRRSRGS232------18-----------113
S231RSYSPRRSRGSPRYS5225--1410--81---15151312----569
S234SPRRSRGSPRYSPRH5549--47349710099-----8276--95--
Showing 1 to 10 of 14 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S182LDNTKFRSHEGETAY-----------
Y189SHEGETAYIRVKVDG-----------
S199VKVDGPRSPSYGRSR1.5e-27--1.4e-212.3e-18-2.4e-51.1e-244.4e-21-0.0977.2e-3
S201VDGPRSPSYGRSRSR0.27--2.1e-68.6e-16------7.3e-40.021
Y202DGPRSPSYGRSRSRS7.8e-10----0.0539.9e-112.8e-17--5.1e-6-
S205RSPSYGRSRSRSRSR3.1e-18--0.64--3.9e-77e-113.1e-10---
S225RSNSRSRSYSPRRSR-----------
S227NSRSRSYSPRRSRGS-----------
S231RSYSPRRSRGSPRYS-----------
S234SPRRSRGSPRYSPRH1.6e-11--5.2e-93.3e-15---6.3e-22---
Showing 1 to 10 of 14 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS182Y189S199S201Y202S205S225S227S231S234Y237S238S242S244proteinRNASCNVmethylationCCRCCS182Y189S199S201Y202S205S225S227S231S234Y237S238S242S244proteinRNASCNVmethylationCOADS182Y189S199S201Y202S205S225S227S231S234Y237S238S242S244proteinRNASCNVmethylationGBMS182Y189S199S201Y202S205S225S227S231S234Y237S238S242S244proteinRNASCNVmethylationHNSCCS182Y189S199S201Y202S205S225S227S231S234Y237S238S242S244proteinRNASCNVmethylationLSCCS182Y189S199S201Y202S205S225S227S231S234Y237S238S242S244proteinRNASCNVmethylationLUADS182Y189S199S201Y202S205S225S227S231S234Y237S238S242S244proteinRNASCNVmethylationOVS182Y189S199S201Y202S205S225S227S231S234Y237S238S242S244proteinRNASCNVmethylationPDACS182Y189S199S201Y202S205S225S227S231S234Y237S238S242S244proteinRNASCNVmethylationUCECS182Y189S199S201Y202S205S225S227S231S234Y237S238S242S244proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.