RIPK1: receptor interacting serine/threonine kinase 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
4ith chain A
4ith chain B
4iti chain A
4iti chain B
4itj chain A
4itj chain B
4neu chain A
4neu chain B
5hx6 chain A
5hx6 chain B
5tx5 chain A
5tx5 chain B
5v7z chain B
5v7z chain D
5v7z chain F
5v7z chain H
5zmz chain A
6ac5 chain A
6c3e chain A
6c3e chain B
6c4d chain A
6c4d chain B
6c4d chain C
6c4d chain D
6hho chain A
6hho chain B
6nw2 chain A
6nw2 chain B
6nyh chain A
6nyh chain B
6ocq chain A
6ocq chain B
6r5f chain A
6r5f chain B
6r5f chain C
6r5f chain D
6rln chain A
6rln chain B
7cjb chain D
7cjb chain H
7cjb chain L
7cjb chain P
7fcz chain A
7fcz chain B
7fd0 chain A
7fd0 chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S20 KSSDFLES AELDSGG 1 9 - - - - - - - - - - - - 4 5 - - - - - - S25 LESAELDS GGFGKVS 3 58 - - - - - - - - - - 5 5 13 12 - - - - 19 4 Y289 EEKFRPFY LSQLEES 1 9 9 - - - - - - - - - - - - - - - - - - - S291 KFRPFYLS QLEESVE 1 9 9 - - - - - - - - - - - - - - - - - - - S296 YLSQLEES VEEDVKS 3 35 9 - 5 4 - - - - - - - - 9 8 - - - - - - S309 KSLKKEYS NENAVVK 10 1011 57 - 95 74 11 7 80 - 90 53 69 64 97 88 14 3 75 30 88 16 S320 AVVKRMQS LQLDCVA 10 1553 122 - 103 80 97 100 99 - 108 62 108 99 110 101 83 19 105 44 95 18 S330 LDCVAVPS SRSNSAT 7 82 9 - 4 2 3 6 - - 16 8 5 5 8 8 - - - - 5 3 S331 DCVAVPSS RSNSATE 10 572 9 - 25 24 45 44 72 - 10 6 34 32 26 23 41 11 81 36 48 5 S333 VAVPSSRS NSATEQP 3 84 - - - - - - 72 - - - - - - - - - 2 1 7 2
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S20 KSSDFLES AELDSGG - - - - - - - - - - - S25 LESAELDS GGFGKVS - - - - - - - - - - - Y289 EEKFRPFY LSQLEES - - - - - - - - - - - S291 KFRPFYLS QLEESVE - - - - - - - - - - - S296 YLSQLEES VEEDVKS - - - - - - - - - - - S309 KSLKKEYS NENAVVK 1.4e-23 - 0.28 - - 8.2e-11 4.0e-6 1.9e-12 - 2.4e-6 0.56 S320 AVVKRMQS LQLDCVA 0.033 - 2e-9 -6.7e-3 - 0.017 -0.53 0.15 -5.2e-4 2.4e-7 -0.032 S330 LDCVAVPS SRSNSAT - - - - - - - - - - - S331 DCVAVPSS RSNSATE -0.16 - 9.9e-3 -0.15 - - -0.14 -0.85 -0.022 -0.55 - S333 VAVPSSRS NSATEQP - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S20
S25
Y289
S291
S296
S309
S320
S330
S331
S333
S335
T337
S342
Y387
S389
S416
S581
S610
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S20 S25 Y289 S291 S296 S309 S320 S330 S331 S333 S335 T337 S342 Y387 S389 S416 S581 S610 protein RNA SCNV methylation CCRCC S20 S25 Y289 S291 S296 S309 S320 S330 S331 S333 S335 T337 S342 Y387 S389 S416 S581 S610 protein RNA SCNV methylation COAD S20 S25 Y289 S291 S296 S309 S320 S330 S331 S333 S335 T337 S342 Y387 S389 S416 S581 S610 protein RNA SCNV methylation GBM S20 S25 Y289 S291 S296 S309 S320 S330 S331 S333 S335 T337 S342 Y387 S389 S416 S581 S610 protein RNA SCNV methylation HNSCC S20 S25 Y289 S291 S296 S309 S320 S330 S331 S333 S335 T337 S342 Y387 S389 S416 S581 S610 protein RNA SCNV methylation LSCC S20 S25 Y289 S291 S296 S309 S320 S330 S331 S333 S335 T337 S342 Y387 S389 S416 S581 S610 protein RNA SCNV methylation LUAD S20 S25 Y289 S291 S296 S309 S320 S330 S331 S333 S335 T337 S342 Y387 S389 S416 S581 S610 protein RNA SCNV methylation OV S20 S25 Y289 S291 S296 S309 S320 S330 S331 S333 S335 T337 S342 Y387 S389 S416 S581 S610 protein RNA SCNV methylation PDAC S20 S25 Y289 S291 S296 S309 S320 S330 S331 S333 S335 T337 S342 Y387 S389 S416 S581 S610 protein RNA SCNV methylation UCEC S20 S25 Y289 S291 S296 S309 S320 S330 S331 S333 S335 T337 S342 Y387 S389 S416 S581 S610 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S20
S25
Y289
S291
S296
S309
S320
S330
S331
S333
S335
T337
S342
Y387
S389
S416
S581
S610
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S20
S25
Y289
S291
S296
S309
S320
S330
S331
S333
S335
T337
S342
Y387
S389
S416
S581
S610
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.