Protein: ENSP00000260810
Gene: TOPBP1

LinkedOmicsKB © 2022-2023 Zhang Lab

TOPBP1:
DNA topoisomerase II binding protein 1

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S142VYRDLNVSVTHLIAG122------------------202
T144RDLNVSVTHLIAGEV122------------------202
T298KTMPNSSTPTSQINT417361-----17---3835------184
T779THRKTVVTPLDMNRF4786---------3027--72--6-
S796KAFRAVVSQHARQVA118----------108--------
S805HARQVAASPAVGQPL411315-----9---1010------609
S817QPLQKEPSLHLDTPS94718-1312--9-1466053776777161043411
T822EPSLHLDTPSKFLSK4798-------7399--367----
S853LETPGRPSQQKRKPS218--------54----72----
S860SQQKRKPSTPLSEVI71658-----9-5132558972209--
Showing 1 to 10 of 18 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S142VYRDLNVSVTHLIAG-----------
T144RDLNVSVTHLIAGEV-----------
T298KTMPNSSTPTSQINT0.052-----0.052----
T779THRKTVVTPLDMNRF2.5e-8-----2.5e-8----
S796KAFRAVVSQHARQVA-----------
S805HARQVAASPAVGQPL-----------
S817QPLQKEPSLHLDTPS5.9e-11-----1.3e-56.2e-100.014-0.93
T822EPSLHLDTPSKFLSK-----------
S853LETPGRPSQQKRKPS-----------
S860SQQKRKPSTPLSEVI0.047----0.047-----
Showing 1 to 10 of 18 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS142T144T298T779S796S805S817T822S853S860T861S888S1002S1016S1138T1221T1231S1504proteinRNASCNVmethylationCCRCCS142T144T298T779S796S805S817T822S853S860T861S888S1002S1016S1138T1221T1231S1504proteinRNASCNVmethylationCOADS142T144T298T779S796S805S817T822S853S860T861S888S1002S1016S1138T1221T1231S1504proteinRNASCNVmethylationGBMS142T144T298T779S796S805S817T822S853S860T861S888S1002S1016S1138T1221T1231S1504proteinRNASCNVmethylationHNSCCS142T144T298T779S796S805S817T822S853S860T861S888S1002S1016S1138T1221T1231S1504proteinRNASCNVmethylationLSCCS142T144T298T779S796S805S817T822S853S860T861S888S1002S1016S1138T1221T1231S1504proteinRNASCNVmethylationLUADS142T144T298T779S796S805S817T822S853S860T861S888S1002S1016S1138T1221T1231S1504proteinRNASCNVmethylationOVS142T144T298T779S796S805S817T822S853S860T861S888S1002S1016S1138T1221T1231S1504proteinRNASCNVmethylationPDACS142T144T298T779S796S805S817T822S853S860T861S888S1002S1016S1138T1221T1231S1504proteinRNASCNVmethylationUCECS142T144T298T779S796S805S817T822S853S860T861S888S1002S1016S1138T1221T1231S1504proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.