TBC1D1: TBC1 domain family member 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
3qye chain A
3qye chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S69 KQVRLCVS PSGLRCE 2 70 9 - - - - - - - - - - - - - - - - - 47 14 S146 KVPEIISS IRQAGKI 1 8 - - 4 4 - - - - - - - - - - - - - - - - S211 SGSRGSES PRPNPPH 6 228 - - 8 8 - - 35 - - - 55 49 9 8 - - 5 1 43 7 S235 VRRPMRKS FSQPGLR 8 953 90 - 67 53 - - 91 - 69 40 99 91 72 64 - - 83 36 89 9 S237 RPMRKSFS QPGLRSL 8 1207 122 - 96 73 - - 90 - 108 62 103 95 110 101 - - 105 43 81 18 S263 RSSGFFSS FEESDIE 8 320 22 - 4 3 - - 88 - 21 14 6 7 51 44 - - 12 4 28 16 S267 FFSSFEES DIENHLI 6 129 18 - 31 26 - - 9 - 13 6 9 9 4 4 - - - - - - S275 DIENHLIS GHNIVQP 1 9 - - - - - - - - - - 4 5 - - - - - - - - S503 LKNKAKRS LTESLES 8 653 31 - 18 16 - - 90 - 70 39 50 45 36 32 - - 96 41 73 16 T505 NKAKRSLT ESLESIL 5 190 - - 25 23 - - - - - - 10 10 40 37 - - 5 1 36 3
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S69 KQVRLCVS PSGLRCE 3.4e-5 - - - - - - - - - 3.4e-5 S146 KVPEIISS IRQAGKI - - - - - - - - - - - S211 SGSRGSES PRPNPPH -0.72 - - - - - -0.72 - - - - S235 VRRPMRKS FSQPGLR -1.8e-29 - -1e-8 - - -3.4e-4 -1.2e-25 -3.4e-14 - 0.031 - S237 RPMRKSFS QPGLRSL -5.5e-4 - -2.9e-25 - - 3.3e-6 -0.014 -2.6e-6 - 4.3e-11 -0.031 S263 RSSGFFSS FEESDIE -3.0e-5 - - - - -1.6e-3 - -8.4e-4 - - -0.46 S267 FFSSFEES DIENHLI -0.76 - -0.76 - - - - - - - - S275 DIENHLIS GHNIVQP - - - - - - - - - - - S503 LKNKAKRS LTESLES -1.1e-5 - - - - -0.016 -1.9e-8 -8.9e-4 - 3.5e-7 -3.7e-4 T505 NKAKRSLT ESLESIL -5.6e-6 - -0.057 - - - - -6.2e-6 - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S69
S146
S211
S235
S237
S263
S267
S275
S503
T505
S507
S525
S527
S556
S558
S559
S565
S566
S570
S571
S573
S575
S585
T596
S598
S614
S618
S627
S629
S649
T652
S695
S747
S1071
S1072
S1150
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S69 S146 S211 S235 S237 S263 S267 S275 S503 T505 S507 S525 S527 S556 S558 S559 S565 S566 S570 S571 S573 S575 S585 T596 S598 S614 S618 S627 S629 S649 T652 S695 S747 S1071 S1072 S1150 protein RNA SCNV methylation CCRCC S69 S146 S211 S235 S237 S263 S267 S275 S503 T505 S507 S525 S527 S556 S558 S559 S565 S566 S570 S571 S573 S575 S585 T596 S598 S614 S618 S627 S629 S649 T652 S695 S747 S1071 S1072 S1150 protein RNA SCNV methylation COAD S69 S146 S211 S235 S237 S263 S267 S275 S503 T505 S507 S525 S527 S556 S558 S559 S565 S566 S570 S571 S573 S575 S585 T596 S598 S614 S618 S627 S629 S649 T652 S695 S747 S1071 S1072 S1150 protein RNA SCNV methylation GBM S69 S146 S211 S235 S237 S263 S267 S275 S503 T505 S507 S525 S527 S556 S558 S559 S565 S566 S570 S571 S573 S575 S585 T596 S598 S614 S618 S627 S629 S649 T652 S695 S747 S1071 S1072 S1150 protein RNA SCNV methylation HNSCC S69 S146 S211 S235 S237 S263 S267 S275 S503 T505 S507 S525 S527 S556 S558 S559 S565 S566 S570 S571 S573 S575 S585 T596 S598 S614 S618 S627 S629 S649 T652 S695 S747 S1071 S1072 S1150 protein RNA SCNV methylation LSCC S69 S146 S211 S235 S237 S263 S267 S275 S503 T505 S507 S525 S527 S556 S558 S559 S565 S566 S570 S571 S573 S575 S585 T596 S598 S614 S618 S627 S629 S649 T652 S695 S747 S1071 S1072 S1150 protein RNA SCNV methylation LUAD S69 S146 S211 S235 S237 S263 S267 S275 S503 T505 S507 S525 S527 S556 S558 S559 S565 S566 S570 S571 S573 S575 S585 T596 S598 S614 S618 S627 S629 S649 T652 S695 S747 S1071 S1072 S1150 protein RNA SCNV methylation OV S69 S146 S211 S235 S237 S263 S267 S275 S503 T505 S507 S525 S527 S556 S558 S559 S565 S566 S570 S571 S573 S575 S585 T596 S598 S614 S618 S627 S629 S649 T652 S695 S747 S1071 S1072 S1150 protein RNA SCNV methylation PDAC S69 S146 S211 S235 S237 S263 S267 S275 S503 T505 S507 S525 S527 S556 S558 S559 S565 S566 S570 S571 S573 S575 S585 T596 S598 S614 S618 S627 S629 S649 T652 S695 S747 S1071 S1072 S1150 protein RNA SCNV methylation UCEC S69 S146 S211 S235 S237 S263 S267 S275 S503 T505 S507 S525 S527 S556 S558 S559 S565 S566 S570 S571 S573 S575 S585 T596 S598 S614 S618 S627 S629 S649 T652 S695 S747 S1071 S1072 S1150 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S69
S146
S211
S235
S237
S263
S267
S275
S503
T505
S507
S525
S527
S556
S558
S559
S565
S566
S570
S571
S573
S575
S585
T596
S598
S614
S618
S627
S629
S649
T652
S695
S747
S1071
S1072
S1150
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S69
S146
S211
S235
S237
S263
S267
S275
S503
T505
S507
S525
S527
S556
S558
S559
S565
S566
S570
S571
S573
S575
S585
T596
S598
S614
S618
S627
S629
S649
T652
S695
S747
S1071
S1072
S1150
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.