Protein: ENSP00000261461
Gene: PPP2R5A

LinkedOmicsKB © 2022-2023 Zhang Lab

PPP2R5A:
protein phosphatase 2 regulatory subunit B'alpha

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S38KAQRQKRSQGSSQFR7397----374472-2513353415123912--572
S41RQKRSQGSSQFRSQG10123465-3933939590-97561089910193491092375918
S42QKRSQGSSQFRSQGS1054214-8260737936-44403654491042319
S46QGSSQFRSQGSQAEL18--------------71----
S49SQFRSQGSQAELHPL10119992-8772727199-854769638681541384347713
S435KLFDDLTSSYKAERQ110----------55--------
S472KALEKQNSAYNMHSI72698---3654---35342724--26122614
Y474LEKQNSAYNMHSILS321----54----------516-
Showing 1 to 8 of 8 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S38KAQRQKRSQGSSQFR-1.9e-15---0.91--9.7e-7-1e-7--2.5e-8--
S41RQKRSQGSSQFRSQG-2.7e-34-1.1e-6-9.3e-12--7.9e-20-7.1e-29-3.1e-31-0.0842.8e-5-1.6e-3
S42QKRSQGSSQFRSQGS-1e-15-3.1e-9-8e-20---3.8e-18--3.0e-5--
S46QGSSQFRSQGSQAEL-----------
S49SQFRSQGSQAELHPL-2.1e-8-2.9e-3-0.35--4.9e-5-2.9e-11-0.01-1.2e-3-0.81-0.27
S435KLFDDLTSSYKAERQ-----------
S472KALEKQNSAYNMHSI-2.9e-4------5.0e-5-0.01--0.140.39
Y474LEKQNSAYNMHSILS-----------
Showing 1 to 8 of 8 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS38S41S42S46S49S435S472Y474proteinRNASCNVmethylationCCRCCS38S41S42S46S49S435S472Y474proteinRNASCNVmethylationCOADS38S41S42S46S49S435S472Y474proteinRNASCNVmethylationGBMS38S41S42S46S49S435S472Y474proteinRNASCNVmethylationHNSCCS38S41S42S46S49S435S472Y474proteinRNASCNVmethylationLSCCS38S41S42S46S49S435S472Y474proteinRNASCNVmethylationLUADS38S41S42S46S49S435S472Y474proteinRNASCNVmethylationOVS38S41S42S46S49S435S472Y474proteinRNASCNVmethylationPDACS38S41S42S46S49S435S472Y474proteinRNASCNVmethylationUCECS38S41S42S46S49S435S472Y474proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.