Protein: ENSP00000261601
Gene: USP14

LinkedOmicsKB © 2022-2023 Zhang Lab

USP14:
ubiquitin specific peptidase 14

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T52KVMVKGGTLKDDDWG980455-9168--62-7846746873697273317-
S74MTLLMMGSADALPEE859447-2523--99-744359553837--18114718
S83DALPEEPSAKTVFVE410833-------241410999------
Y136LKDALKRYAGALRAS221------9---------93--
S143YAGALRASGEMASAQ101517122-103809710099-1086210899110100831982329518
S148RASGEMASAQYITAA11717-------------------
S228DSVKETDSSSASAAT78238-44----525445--416-
S229SVKETDSSSASAATP34815-------53--------232
S230VKETDSSSASAATPS514136-----45-631412------223
S232ETDSSSASAATPSKK227----------109------8-
Showing 1 to 10 of 20 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
T52KVMVKGGTLKDDDWG5.8e-10-0.007--3.1e-62.4e-50.83-0.039-
S74MTLLMMGSADALPEE-8.9e-17--6.0e-5---6.3e-5-1.3e-8-7e-13--0.023
S83DALPEEPSAKTVFVE-0.043-----0.043-----
Y136LKDALKRYAGALRAS-----------
S143YAGALRASGEMASAQ-1.5e-29-1.8e-3-2.1e-12--9e-16-1.3e-10-3.8e-24-0.0170.081-5.7e-3
S148RASGEMASAQYITAA-----------
S228DSVKETDSSSASAAT-----------
S229SVKETDSSSASAATP-----------
S230VKETDSSSASAATPS-----------
S232ETDSSSASAATPSKK-----------
Showing 1 to 10 of 20 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAT52S74S83Y136S143S148S228S229S230S232T235S260S338T388S389S394S430Y476Y480S492proteinRNASCNVmethylationCCRCCT52S74S83Y136S143S148S228S229S230S232T235S260S338T388S389S394S430Y476Y480S492proteinRNASCNVmethylationCOADT52S74S83Y136S143S148S228S229S230S232T235S260S338T388S389S394S430Y476Y480S492proteinRNASCNVmethylationGBMT52S74S83Y136S143S148S228S229S230S232T235S260S338T388S389S394S430Y476Y480S492proteinRNASCNVmethylationHNSCCT52S74S83Y136S143S148S228S229S230S232T235S260S338T388S389S394S430Y476Y480S492proteinRNASCNVmethylationLSCCT52S74S83Y136S143S148S228S229S230S232T235S260S338T388S389S394S430Y476Y480S492proteinRNASCNVmethylationLUADT52S74S83Y136S143S148S228S229S230S232T235S260S338T388S389S394S430Y476Y480S492proteinRNASCNVmethylationOVT52S74S83Y136S143S148S228S229S230S232T235S260S338T388S389S394S430Y476Y480S492proteinRNASCNVmethylationPDACT52S74S83Y136S143S148S228S229S230S232T235S260S338T388S389S394S430Y476Y480S492proteinRNASCNVmethylationUCECT52S74S83Y136S143S148S228S229S230S232T235S260S338T388S389S394S430Y476Y480S492proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

Loading, please wait
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.