CAMK2A: calcium/calmodulin dependent protein kinase II alpha
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2vz6 chain A
2vz6 chain B
3soa chain A
5ig3 chain A
5ig3 chain B
5ig3 chain C
5ig3 chain D
5ig3 chain E
5ig3 chain F
6of8 chain A
6of8 chain B
6of8 chain C
6of8 chain D
6of8 chain E
6of8 chain F
6of8 chain G
6vzk chain A
6w4o chain A
6w4o chain B
6w4o chain C
6w4o chain D
6w4o chain E
6w4o chain F
6w4o chain G
6w4o chain I
6w4o chain J
6w4o chain K
6w4o chain L
6w4o chain M
6w4o chain O
6w4p chain A
6w4p chain B
6w4p chain C
6w4p chain D
6w4p chain E
6w4p chain F
6w4p chain G
6w4p chain H
6w4p chain I
6w4p chain J
6w4p chain K
6w4p chain L
6w4p chain M
6x5g chain A
6x5q chain A
7kl0 chain A
7kl0 chain B
7kl1 chain A
7kl1 chain B
7kl2 chain A
7rec chain A
7rec chain B
7rec chain C
7rec chain D
7rec chain E
7rec chain F
7rec chain G
7uiq chain A
7uiq chain B
7uir chain A
7uir chain B
7uis chain A
7ujp chain A
7ujp chain B
7ujq chain A
7ujq chain B
7ujr chain A
7ujs chain A
7ujt chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S80 VRLHDSIS EEGHHYL 1 6 - - - - - - 6 - - - - - - - - - - - - - Y86 ISEEGHHY LIFDLVT 1 9 - - - - - - 9 - - - - - - - - - - - - - T253 DLINKMLT INPSKRI 1 18 - - - - - - 18 - - - - - - - - - - - - - S257 KMLTINPS KRITAAE 1 72 - - - - - - 72 - - - - - - - - - - - - - T261 INPSKRIT AAEALKH 1 82 - - - - - - 82 - - - - - - - - - - - - - S272 ALKHPWIS HRSTVAS 1 99 - - - - - - 99 - - - - - - - - - - - - - S275 HPWISHRS TVASCMH 1 99 - - - - - - 99 - - - - - - - - - - - - - T276 PWISHRST VASCMHR 1 53 - - - - - - 53 - - - - - - - - - - - - - S279 SHRSTVAS CMHRQET 1 99 - - - - - - 99 - - - - - - - - - - - - - T286 SCMHRQET VDCLKKF 1 32 - - - - - - 32 - - - - - - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S80 VRLHDSIS EEGHHYL - - - - - - - - - - - Y86 ISEEGHHY LIFDLVT - - - - - - - - - - - T253 DLINKMLT INPSKRI - - - - - - - - - - - S257 KMLTINPS KRITAAE - - - - - - - - - - - T261 INPSKRIT AAEALKH - - - - - - - - - - - S272 ALKHPWIS HRSTVAS - - - - - - - - - - - S275 HPWISHRS TVASCMH - - - - - - - - - - - T276 PWISHRST VASCMHR - - - - - - - - - - - S279 SHRSTVAS CMHRQET - - - - - - - - - - - T286 SCMHRQET VDCLKKF - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S80
Y86
T253
S257
T261
S272
S275
T276
S279
T286
T305
T310
S314
S324
S330
S331
S333
T334
T336
T337
T343
S368
S404
S407
S470
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S80 Y86 T253 S257 T261 S272 S275 T276 S279 T286 T305 T310 S314 S324 S330 S331 S333 T334 T336 T337 T343 S368 S404 S407 S470 protein RNA SCNV methylation CCRCC S80 Y86 T253 S257 T261 S272 S275 T276 S279 T286 T305 T310 S314 S324 S330 S331 S333 T334 T336 T337 T343 S368 S404 S407 S470 protein RNA SCNV methylation COAD S80 Y86 T253 S257 T261 S272 S275 T276 S279 T286 T305 T310 S314 S324 S330 S331 S333 T334 T336 T337 T343 S368 S404 S407 S470 protein RNA SCNV methylation GBM S80 Y86 T253 S257 T261 S272 S275 T276 S279 T286 T305 T310 S314 S324 S330 S331 S333 T334 T336 T337 T343 S368 S404 S407 S470 protein RNA SCNV methylation HNSCC S80 Y86 T253 S257 T261 S272 S275 T276 S279 T286 T305 T310 S314 S324 S330 S331 S333 T334 T336 T337 T343 S368 S404 S407 S470 protein RNA SCNV methylation LSCC S80 Y86 T253 S257 T261 S272 S275 T276 S279 T286 T305 T310 S314 S324 S330 S331 S333 T334 T336 T337 T343 S368 S404 S407 S470 protein RNA SCNV methylation LUAD S80 Y86 T253 S257 T261 S272 S275 T276 S279 T286 T305 T310 S314 S324 S330 S331 S333 T334 T336 T337 T343 S368 S404 S407 S470 protein RNA SCNV methylation OV S80 Y86 T253 S257 T261 S272 S275 T276 S279 T286 T305 T310 S314 S324 S330 S331 S333 T334 T336 T337 T343 S368 S404 S407 S470 protein RNA SCNV methylation PDAC S80 Y86 T253 S257 T261 S272 S275 T276 S279 T286 T305 T310 S314 S324 S330 S331 S333 T334 T336 T337 T343 S368 S404 S407 S470 protein RNA SCNV methylation UCEC S80 Y86 T253 S257 T261 S272 S275 T276 S279 T286 T305 T310 S314 S324 S330 S331 S333 T334 T336 T337 T343 S368 S404 S407 S470 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S80
Y86
T253
S257
T261
S272
S275
T276
S279
T286
T305
T310
S314
S324
S330
S331
S333
T334
T336
T337
T343
S368
S404
S407
S470
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S80
Y86
T253
S257
T261
S272
S275
T276
S279
T286
T305
T310
S314
S324
S330
S331
S333
T334
T336
T337
T343
S368
S404
S407
S470
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.