CIT: citron rho-interacting serine/threonine kinase
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S381 PFVPTLKS DDDTSNF 1 14 - - - - - - - - - - - - - - - - - - 14 - T385 TLKSDDDT SNFDEPE 1 14 - - - - - - - - - - - - - - - - - - 14 - S386 LKSDDDTS NFDEPEK 1 14 - - - - - - - - - - - - - - - - - - 14 - S433 GILGRSES VVSGLDS 6 128 - - 4 4 - - 27 - - - 20 20 9 8 - - 5 2 25 4 S440 SVVSGLDS PAKTSSM 7 732 - - 23 21 - - 45 - 85 49 98 89 88 80 - - 34 13 89 18 S480 TRLHRRVS EVEAVLS 7 913 - - 103 80 - - 99 - 97 54 80 71 110 101 - - 30 12 58 18 S582 LVSARRRS DLYESEL 6 152 - - - - - - 9 - 13 6 29 26 10 8 - - 5 1 31 14 T1017 QTMEALKT TCTMLEE 1 12 - - - - - - - - - - - - - - - - 9 3 - - S1192 DLLKTERS DLEYQLE 2 25 - - 8 8 - - 9 - - - - - - - - - - - - - T1306 TDHPHPST PATARQQ 1 8 - - - - - - 8 - - - - - - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S381 PFVPTLKS DDDTSNF - - - - - - - - - - - T385 TLKSDDDT SNFDEPE - - - - - - - - - - - S386 LKSDDDTS NFDEPEK - - - - - - - - - - - S433 GILGRSES VVSGLDS 2.8e-10 - - - - - 2.8e-10 - - - - S440 SVVSGLDS PAKTSSM 1.7e-55 - 5.7e-5 - - 5.8e-14 2.2e-31 5.5e-25 - 4.2e-3 0.038 S480 TRLHRRVS EVEAVLS 2.1e-30 - 3.7e-18 - - 1.3e-3 1e-14 3.2e-15 - 0.064 -0.19 S582 LVSARRRS DLYESEL 2.9e-16 - - - - - 1.5e-13 - - - 3.0e-5 T1017 QTMEALKT TCTMLEE - - - - - - - - - - - S1192 DLLKTERS DLEYQLE - - - - - - - - - - - T1306 TDHPHPST PATARQQ - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S381
T385
S386
S433
S440
S480
S582
T1017
S1192
T1306
S1317
S1322
S1343
S1432
S1582
S1915
S1919
S1920
S1940
S1948
S1954
S1971
S1993
S2026
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S381 T385 S386 S433 S440 S480 S582 T1017 S1192 T1306 S1317 S1322 S1343 S1432 S1582 S1915 S1919 S1920 S1940 S1948 S1954 S1971 S1993 S2026 protein RNA SCNV methylation CCRCC S381 T385 S386 S433 S440 S480 S582 T1017 S1192 T1306 S1317 S1322 S1343 S1432 S1582 S1915 S1919 S1920 S1940 S1948 S1954 S1971 S1993 S2026 protein RNA SCNV methylation COAD S381 T385 S386 S433 S440 S480 S582 T1017 S1192 T1306 S1317 S1322 S1343 S1432 S1582 S1915 S1919 S1920 S1940 S1948 S1954 S1971 S1993 S2026 protein RNA SCNV methylation GBM S381 T385 S386 S433 S440 S480 S582 T1017 S1192 T1306 S1317 S1322 S1343 S1432 S1582 S1915 S1919 S1920 S1940 S1948 S1954 S1971 S1993 S2026 protein RNA SCNV methylation HNSCC S381 T385 S386 S433 S440 S480 S582 T1017 S1192 T1306 S1317 S1322 S1343 S1432 S1582 S1915 S1919 S1920 S1940 S1948 S1954 S1971 S1993 S2026 protein RNA SCNV methylation LSCC S381 T385 S386 S433 S440 S480 S582 T1017 S1192 T1306 S1317 S1322 S1343 S1432 S1582 S1915 S1919 S1920 S1940 S1948 S1954 S1971 S1993 S2026 protein RNA SCNV methylation LUAD S381 T385 S386 S433 S440 S480 S582 T1017 S1192 T1306 S1317 S1322 S1343 S1432 S1582 S1915 S1919 S1920 S1940 S1948 S1954 S1971 S1993 S2026 protein RNA SCNV methylation OV S381 T385 S386 S433 S440 S480 S582 T1017 S1192 T1306 S1317 S1322 S1343 S1432 S1582 S1915 S1919 S1920 S1940 S1948 S1954 S1971 S1993 S2026 protein RNA SCNV methylation PDAC S381 T385 S386 S433 S440 S480 S582 T1017 S1192 T1306 S1317 S1322 S1343 S1432 S1582 S1915 S1919 S1920 S1940 S1948 S1954 S1971 S1993 S2026 protein RNA SCNV methylation UCEC S381 T385 S386 S433 S440 S480 S582 T1017 S1192 T1306 S1317 S1322 S1343 S1432 S1582 S1915 S1919 S1920 S1940 S1948 S1954 S1971 S1993 S2026 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S381
T385
S386
S433
S440
S480
S582
T1017
S1192
T1306
S1317
S1322
S1343
S1432
S1582
S1915
S1919
S1920
S1940
S1948
S1954
S1971
S1993
S2026
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S381
T385
S386
S433
S440
S480
S582
T1017
S1192
T1306
S1317
S1322
S1343
S1432
S1582
S1915
S1919
S1920
S1940
S1948
S1954
S1971
S1993
S2026
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.