Protein: ENSP00000261845
Gene: MAPK6

LinkedOmicsKB © 2022-2023 Zhang Lab

MAPK6:
mitogen-activated protein kinase 6

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S189YSHKGHLSEGLVTKW101311113-7252695781-108627469106978319100428918
S363RYHDCQFSEHDWPVH156----------3026--------
S386QLDPRALSDVTDEEE73077-1615----703834322420--52386
T389PRALSDVTDEEEVQV51778-------7640201744----62
S441KYCDLECSHTCNYKT643232-----26-5831103912218----465
S450TCNYKTRSSSYLDNL18------------------53
S452NYKTRSSSYLDNLVW7248--42--18-281735312723224--2314
Y453YKTRSSSYLDNLVWR18------------44------
S556KLNDLNSSVSQLELK723517-----36-10649441715--52304
S558NDLNSSVSQLELKSL3419---------108------122
Showing 1 to 10 of 13 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S189YSHKGHLSEGLVTKW1.9e-69-5.7e-91.9e-9-7.8e-171.7e-232.8e-220.521.1e-180.62
S363RYHDCQFSEHDWPVH0.38-----0.38----
S386QLDPRALSDVTDEEE7.5e-8----1.4e-139.2e-8-6.3e-4---
T389PRALSDVTDEEEVQV5.2e-23----4.8e-141.3e-10----
S441KYCDLECSHTCNYKT1.1e-45----7.3e-118e-317.1e-11---
S450TCNYKTRSSSYLDNL-----------
S452NYKTRSSSYLDNLVW1.2e-9----1.4e-32.4e-121.5e-5---0.018
Y453YKTRSSSYLDNLVWR-----------
S556KLNDLNSSVSQLELK2.8e-12-----2.8e-12----
S558NDLNSSVSQLELKSL-----------
Showing 1 to 10 of 13 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS189S363S386T389S441S450S452Y453S556S558S665S684S688proteinRNASCNVmethylationCCRCCS189S363S386T389S441S450S452Y453S556S558S665S684S688proteinRNASCNVmethylationCOADS189S363S386T389S441S450S452Y453S556S558S665S684S688proteinRNASCNVmethylationGBMS189S363S386T389S441S450S452Y453S556S558S665S684S688proteinRNASCNVmethylationHNSCCS189S363S386T389S441S450S452Y453S556S558S665S684S688proteinRNASCNVmethylationLSCCS189S363S386T389S441S450S452Y453S556S558S665S684S688proteinRNASCNVmethylationLUADS189S363S386T389S441S450S452Y453S556S558S665S684S688proteinRNASCNVmethylationOVS189S363S386T389S441S450S452Y453S556S558S665S684S688proteinRNASCNVmethylationPDACS189S363S386T389S441S450S452Y453S556S558S665S684S688proteinRNASCNVmethylationUCECS189S363S386T389S441S450S452Y453S556S558S665S684S688proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.