RBL2: RB transcriptional corepressor like 2
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
4xi9 chain E
4xi9 chain F
4xi9 chain G
4xi9 chain H
5c1d chain C
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S8 MPSGGDQS PPPPPPP 7 622 104 - 29 28 21 14 9 - - - 79 70 98 86 - - - - 66 18 S21 PPPAAAAS DEEEEDD 8 557 6 - 29 28 21 14 35 - 5 2 79 70 98 86 - - - - 66 18 S40 DAAPPAES PTPQIQQ 6 271 24 - 4 4 9 9 - - - - 29 21 53 47 - - - - 53 18 S373 SRCLNAGS GTETAER 3 66 33 - - - - - - - - - - - 5 4 - - - - 18 6 T401 SKALRIST PLTGVRY 10 764 95 - 30 28 10 8 72 - 21 11 83 76 84 78 62 15 18 7 55 11 S413 VRYIKENS PCVTPVS 10 642 47 - 25 23 22 23 53 - 95 55 29 28 45 39 62 14 8 3 53 18 T417 KENSPCVT PVSTATH 8 225 - - 5 4 4 5 27 - 42 21 29 26 10 8 29 6 - - 7 2 S639 DEICIAGS PLTPRRV 10 1264 112 - 95 72 12 15 99 - 108 62 108 99 105 97 36 5 88 38 95 18 T642 CIAGSPLT PRRVTEV 10 848 96 - 48 36 11 7 45 - 62 35 60 53 98 89 58 11 27 12 84 16 T661 GGLGRSIT SPTTLYD 1 9 - - - - - - 9 - - - - - - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S8 MPSGGDQS PPPPPPP 0.044 - -0.025 -0.91 - - 1.8e-7 1.3e-7 - - -2.8e-4 S21 PPPAAAAS DEEEEDD 0.046 - -0.022 -0.91 - - 1.8e-7 1.3e-7 - - -2.8e-4 S40 DAAPPAES PTPQIQQ 0.011 - - - - - 0.022 0.011 - - -0.65 S373 SRCLNAGS GTETAER - - - - - - - - - - - T401 SKALRIST PLTGVRY 6.7e-23 - 8.3e-12 - - 8.3e-3 6.6e-7 2.2e-16 0.069 - -0.73 S413 VRYIKENS PCVTPVS -7.1e-5 - -0.045 -0.016 - -0.024 -0.12 -0.022 0.98 - -0.98 T417 KENSPCVT PVSTATH -0.23 - - - - 0.25 -4.4e-3 - - - - S639 DEICIAGS PLTPRRV -3.4e-5 - -1.2e-6 - - -0.015 0.33 -0.49 - -1.1e-3 0.91 T642 CIAGSPLT PRRVTEV -2.1e-8 - -4.7e-3 - - -0.069 -0.033 -0.62 -4.9e-3 -3.8e-5 -0.54 T661 GGLGRSIT SPTTLYD - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S8
S21
S40
S373
T401
S413
T417
S639
T642
T661
S662
S671
S672
S688
T694
S948
S952
T954
T961
S962
S965
S966
S973
T974
S981
S982
T986
S995
S1035
S1059
S1068
S1080
T1097
S1112
S1138
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S8 S21 S40 S373 T401 S413 T417 S639 T642 T661 S662 S671 S672 S688 T694 S948 S952 T954 T961 S962 S965 S966 S973 T974 S981 S982 T986 S995 S1035 S1059 S1068 S1080 T1097 S1112 S1138 protein RNA SCNV methylation CCRCC S8 S21 S40 S373 T401 S413 T417 S639 T642 T661 S662 S671 S672 S688 T694 S948 S952 T954 T961 S962 S965 S966 S973 T974 S981 S982 T986 S995 S1035 S1059 S1068 S1080 T1097 S1112 S1138 protein RNA SCNV methylation COAD S8 S21 S40 S373 T401 S413 T417 S639 T642 T661 S662 S671 S672 S688 T694 S948 S952 T954 T961 S962 S965 S966 S973 T974 S981 S982 T986 S995 S1035 S1059 S1068 S1080 T1097 S1112 S1138 protein RNA SCNV methylation GBM S8 S21 S40 S373 T401 S413 T417 S639 T642 T661 S662 S671 S672 S688 T694 S948 S952 T954 T961 S962 S965 S966 S973 T974 S981 S982 T986 S995 S1035 S1059 S1068 S1080 T1097 S1112 S1138 protein RNA SCNV methylation HNSCC S8 S21 S40 S373 T401 S413 T417 S639 T642 T661 S662 S671 S672 S688 T694 S948 S952 T954 T961 S962 S965 S966 S973 T974 S981 S982 T986 S995 S1035 S1059 S1068 S1080 T1097 S1112 S1138 protein RNA SCNV methylation LSCC S8 S21 S40 S373 T401 S413 T417 S639 T642 T661 S662 S671 S672 S688 T694 S948 S952 T954 T961 S962 S965 S966 S973 T974 S981 S982 T986 S995 S1035 S1059 S1068 S1080 T1097 S1112 S1138 protein RNA SCNV methylation LUAD S8 S21 S40 S373 T401 S413 T417 S639 T642 T661 S662 S671 S672 S688 T694 S948 S952 T954 T961 S962 S965 S966 S973 T974 S981 S982 T986 S995 S1035 S1059 S1068 S1080 T1097 S1112 S1138 protein RNA SCNV methylation OV S8 S21 S40 S373 T401 S413 T417 S639 T642 T661 S662 S671 S672 S688 T694 S948 S952 T954 T961 S962 S965 S966 S973 T974 S981 S982 T986 S995 S1035 S1059 S1068 S1080 T1097 S1112 S1138 protein RNA SCNV methylation PDAC S8 S21 S40 S373 T401 S413 T417 S639 T642 T661 S662 S671 S672 S688 T694 S948 S952 T954 T961 S962 S965 S966 S973 T974 S981 S982 T986 S995 S1035 S1059 S1068 S1080 T1097 S1112 S1138 protein RNA SCNV methylation UCEC S8 S21 S40 S373 T401 S413 T417 S639 T642 T661 S662 S671 S672 S688 T694 S948 S952 T954 T961 S962 S965 S966 S973 T974 S981 S982 T986 S995 S1035 S1059 S1068 S1080 T1097 S1112 S1138 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S8
S21
S40
S373
T401
S413
T417
S639
T642
T661
S662
S671
S672
S688
T694
S948
S952
T954
T961
S962
S965
S966
S973
T974
S981
S982
T986
S995
S1035
S1059
S1068
S1080
T1097
S1112
S1138
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S8
S21
S40
S373
T401
S413
T417
S639
T642
T661
S662
S671
S672
S688
T694
S948
S952
T954
T961
S962
S965
S966
S973
T974
S981
S982
T986
S995
S1035
S1059
S1068
S1080
T1097
S1112
S1138
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.