ARFGEF1: ADP ribosylation factor guanine nucleotide exchange factor 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
3ltl chain A
3ltl chain B
5ee5 chain A
5j5c chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S31 EVKKAHHS QLRKACE 2 61 - - - - - - 36 - - - - - - - 21 4 - - - - T48 LEEIKAET EKQSPPH 1 8 8 - - - - - - - - - - - - - - - - - - - S52 KAETEKQS PPHGEAK 10 1513 122 - 103 80 93 95 99 - 108 62 108 99 110 101 68 16 100 43 88 18 S70 STLPPVKS KTNFIEA 2 51 - - - - 6 3 - - - - - - - - 33 9 - - - - S234 QHHHLLQS PVSHHEP 5 184 15 - - - - - 62 - 5 4 30 27 22 19 - - - - - - S237 HLLQSPVS HHEPESP 6 121 8 - 4 4 - - 19 - - - 14 13 18 16 - - 17 8 - - S243 VSHHEPES PQLRYLP 4 61 9 - - - - - 18 - - - 5 4 13 12 - - - - - - S258 PQTVDHIS QEHEGDL 1 9 9 - - - - - - - - - - - - - - - - - - - S275 HTNDVDKS LQDDTEP 4 88 9 - - - - - - - - - 19 18 5 4 - - - - 29 4 T280 DKSLQDDT EPENGSD 8 147 22 - 5 4 9 9 10 - - - 5 4 24 20 - - 11 4 18 2
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S31 EVKKAHHS QLRKACE - - - - - - - - - - - T48 LEEIKAET EKQSPPH - - - - - - - - - - - S52 KAETEKQS PPHGEAK 4.9e-80 - 0.011 5.4e-12 - 4.8e-18 3.1e-31 6.3e-33 4.6e-3 9.1e-7 2.9e-5 S70 STLPPVKS KTNFIEA - - - - - - - - - - - S234 QHHHLLQS PVSHHEP 6.6e-3 - - - - - 0.23 8.2e-3 - - - S237 HLLQSPVS HHEPESP - - - - - - - - - - - S243 VSHHEPES PQLRYLP - - - - - - - - - - - S258 PQTVDHIS QEHEGDL - - - - - - - - - - - S275 HTNDVDKS LQDDTEP - - - - - - - - - - - T280 DKSLQDDT EPENGSD 1.7e-8 - - - - - - 1.7e-8 - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S31
T48
S52
S70
S234
S237
S243
S258
S275
T280
S286
S289
S290
T296
T302
S308
S396
S397
T400
S403
S406
S410
S636
T638
S646
Y662
S664
S667
S670
T671
S672
S678
Y679
T681
S684
T686
S897
S1079
T1081
T1083
S1249
S1546
T1549
S1555
S1558
T1564
S1566
S1569
S1580
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S31 T48 S52 S70 S234 S237 S243 S258 S275 T280 S286 S289 S290 T296 T302 S308 S396 S397 T400 S403 S406 S410 S636 T638 S646 Y662 S664 S667 S670 T671 S672 S678 Y679 T681 S684 T686 S897 S1079 T1081 T1083 S1249 S1546 T1549 S1555 S1558 T1564 S1566 S1569 S1580 protein RNA SCNV methylation CCRCC S31 T48 S52 S70 S234 S237 S243 S258 S275 T280 S286 S289 S290 T296 T302 S308 S396 S397 T400 S403 S406 S410 S636 T638 S646 Y662 S664 S667 S670 T671 S672 S678 Y679 T681 S684 T686 S897 S1079 T1081 T1083 S1249 S1546 T1549 S1555 S1558 T1564 S1566 S1569 S1580 protein RNA SCNV methylation COAD S31 T48 S52 S70 S234 S237 S243 S258 S275 T280 S286 S289 S290 T296 T302 S308 S396 S397 T400 S403 S406 S410 S636 T638 S646 Y662 S664 S667 S670 T671 S672 S678 Y679 T681 S684 T686 S897 S1079 T1081 T1083 S1249 S1546 T1549 S1555 S1558 T1564 S1566 S1569 S1580 protein RNA SCNV methylation GBM S31 T48 S52 S70 S234 S237 S243 S258 S275 T280 S286 S289 S290 T296 T302 S308 S396 S397 T400 S403 S406 S410 S636 T638 S646 Y662 S664 S667 S670 T671 S672 S678 Y679 T681 S684 T686 S897 S1079 T1081 T1083 S1249 S1546 T1549 S1555 S1558 T1564 S1566 S1569 S1580 protein RNA SCNV methylation HNSCC S31 T48 S52 S70 S234 S237 S243 S258 S275 T280 S286 S289 S290 T296 T302 S308 S396 S397 T400 S403 S406 S410 S636 T638 S646 Y662 S664 S667 S670 T671 S672 S678 Y679 T681 S684 T686 S897 S1079 T1081 T1083 S1249 S1546 T1549 S1555 S1558 T1564 S1566 S1569 S1580 protein RNA SCNV methylation LSCC S31 T48 S52 S70 S234 S237 S243 S258 S275 T280 S286 S289 S290 T296 T302 S308 S396 S397 T400 S403 S406 S410 S636 T638 S646 Y662 S664 S667 S670 T671 S672 S678 Y679 T681 S684 T686 S897 S1079 T1081 T1083 S1249 S1546 T1549 S1555 S1558 T1564 S1566 S1569 S1580 protein RNA SCNV methylation LUAD S31 T48 S52 S70 S234 S237 S243 S258 S275 T280 S286 S289 S290 T296 T302 S308 S396 S397 T400 S403 S406 S410 S636 T638 S646 Y662 S664 S667 S670 T671 S672 S678 Y679 T681 S684 T686 S897 S1079 T1081 T1083 S1249 S1546 T1549 S1555 S1558 T1564 S1566 S1569 S1580 protein RNA SCNV methylation OV S31 T48 S52 S70 S234 S237 S243 S258 S275 T280 S286 S289 S290 T296 T302 S308 S396 S397 T400 S403 S406 S410 S636 T638 S646 Y662 S664 S667 S670 T671 S672 S678 Y679 T681 S684 T686 S897 S1079 T1081 T1083 S1249 S1546 T1549 S1555 S1558 T1564 S1566 S1569 S1580 protein RNA SCNV methylation PDAC S31 T48 S52 S70 S234 S237 S243 S258 S275 T280 S286 S289 S290 T296 T302 S308 S396 S397 T400 S403 S406 S410 S636 T638 S646 Y662 S664 S667 S670 T671 S672 S678 Y679 T681 S684 T686 S897 S1079 T1081 T1083 S1249 S1546 T1549 S1555 S1558 T1564 S1566 S1569 S1580 protein RNA SCNV methylation UCEC S31 T48 S52 S70 S234 S237 S243 S258 S275 T280 S286 S289 S290 T296 T302 S308 S396 S397 T400 S403 S406 S410 S636 T638 S646 Y662 S664 S667 S670 T671 S672 S678 Y679 T681 S684 T686 S897 S1079 T1081 T1083 S1249 S1546 T1549 S1555 S1558 T1564 S1566 S1569 S1580 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S31
T48
S52
S70
S234
S237
S243
S258
S275
T280
S286
S289
S290
T296
T302
S308
S396
S397
T400
S403
S406
S410
S636
T638
S646
Y662
S664
S667
S670
T671
S672
S678
Y679
T681
S684
T686
S897
S1079
T1081
T1083
S1249
S1546
T1549
S1555
S1558
T1564
S1566
S1569
S1580
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S31
T48
S52
S70
S234
S237
S243
S258
S275
T280
S286
S289
S290
T296
T302
S308
S396
S397
T400
S403
S406
S410
S636
T638
S646
Y662
S664
S667
S670
T671
S672
S678
Y679
T681
S684
T686
S897
S1079
T1081
T1083
S1249
S1546
T1549
S1555
S1558
T1564
S1566
S1569
S1580
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.