- DHX8:
- DEAH-box helicase 8
Lollipop plot
Phosphosites location and occurrence
Structure
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Site
| Sequence | Cohorts | Total | T | N | T | N | T | N | T | N | T | N | T | N | T | N | T | N | T | N | T | N |
S129 | LCQPDNPSVRTMLDE | 1 | 6 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 6 | - |
S226 | KSRYRSRSRSQSPPK | 2 | 52 | - | - | - | - | 12 | 14 | 26 | - | - | - | - | - | - | - | - | - | - | - | - | - |
S228 | RYRSRSRSQSPPKDR | 2 | 52 | - | - | - | - | 12 | 14 | 26 | - | - | - | - | - | - | - | - | - | - | - | - | - |
S230 | RSRSRSQSPPKDRKD | 2 | 52 | - | - | - | - | 12 | 14 | 26 | - | - | - | - | - | - | - | - | - | - | - | - | - |
S395 | RKRLTRISDPEKWEI | 4 | 185 | - | - | - | - | - | - | - | - | 22 | 12 | 30 | 28 | 44 | 40 | - | - | - | - | - | 9 |
S460 | TKQSMDMSPIKIVKN | 10 | 1544 | 122 | - | 103 | 80 | 92 | 96 | 99 | - | 108 | 62 | 108 | 99 | 110 | 101 | 83 | 19 | 105 | 44 | 95 | 18 |
Tumor and normal comparison
Site
| Sequence | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
---|---|---|---|---|---|---|---|---|---|---|---|---|
S129 | LCQPDNPSVRTMLDE | - | - | - | - | - | - | - | - | - | - | - |
S226 | KSRYRSRSRSQSPPK | - | - | - | - | - | - | - | - | - | - | - |
S228 | RYRSRSRSQSPPKDR | - | - | - | - | - | - | - | - | - | - | - |
S230 | RSRSRSQSPPKDRKD | - | - | - | - | - | - | - | - | - | - | - |
S395 | RKRLTRISDPEKWEI | -1.2e-3 | - | - | - | - | 0.34 | -1.6e-6 | -0.081 | - | - | - |
S460 | TKQSMDMSPIKIVKN | 8.5e-27 | - | -3.6e-5 | 1.9e-24 | - | 1.9e-10 | 7.5e-33 | 2.6e-17 | -0.67 | -6.5e-5 | 0.059 |
Phenotype and mutation association
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Site | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
KINASE-PSP_CK2A1/CSNK2A1 | S460 | 1.9e-23 | 4.3e-4 | 0.048 | 0.062 | 9.8e-7 | 8.5e-4 | 5e-8 | 3.1e-5 | -0.023 | 2.3e-3 | 2.6e-8 |
HALLMARK_SPERMATOGENESIS | S460 | 3.2e-19 | 0.001 | 0.033 | -0.87 | 0.13 | 8.8e-8 | 2.2e-16 | 8.1e-5 | 0.16 | 0.41 | 0.068 |
HALLMARK_G2M_CHECKPOINT | S460 | 2.3e-18 | 0.021 | 0.28 | 0.81 | 1.6e-5 | 4.1e-6 | 2.8e-8 | 1.4e-5 | 0.34 | 0.085 | 0.011 |
HALLMARK_E2F_TARGETS | S460 | 2.9e-17 | 1.4e-3 | 0.57 | 0.69 | 3.4e-5 | 3.3e-6 | 3.7e-10 | 7.0e-5 | 0.68 | 0.17 | 0.081 |
chromosomal instability | S460 | 2.3e-13 | 1.8e-3 | -0.5 | 0.46 | 2.8e-3 | 1.1e-7 | 2.2e-16 | 0.26 | -0.59 | 8.7e-3 | 0.79 |
HALLMARK_MYC_TARGETS_V2 | S460 | 1.5e-10 | 6.0e-4 | -0.088 | -0.81 | 0.023 | 3.5e-3 | 8.5e-9 | 4.3e-5 | 0.77 | 0.16 | 0.041 |
Tumor Purity (ABSOLUTE) | S460 | 1.2e-9 | 1.6e-3 | -0.61 | 0.94 | 0.081 | 1.8e-6 | 9.4e-9 | -0.64 | -0.71 | 0.001 | 0.072 |
HALLMARK_MYC_TARGETS_V1 | S460 | 1.3e-9 | 3.6e-3 | -0.91 | 0.4 | 0.02 | 0.35 | 5.7e-7 | 2.0e-4 | 0.21 | 0.5 | 0.11 |
HALLMARK_DNA_REPAIR | S460 | 1.5e-9 | 1.5e-4 | -0.54 | -0.97 | 0.016 | 0.054 | 8.7e-8 | 7.5e-3 | 0.092 | 0.1 | 0.76 |
xcell: T cell CD4+ Th1 | S460 | 2e-9 | 4.1e-3 | -0.87 | 0.34 | 0.019 | 0.011 | 1.3e-5 | 2.5e-3 | -0.99 | 0.2 | 0.079 |
Cis-association
Kinase association
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Kinase | Site | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
No matching records found |
Phosphatase association
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphatase | Site | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
No matching records found |