CSNK2A2: casein kinase 2 alpha 2
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
3e3b chain X
3ofm chain A
3u87 chain A
3u87 chain B
5m4u chain A
5m56 chain A
5m56 chain B
5ooi chain A
5ooi chain B
5y9m chain A
5y9m chain X
5yf9 chain B
5yf9 chain X
5ywm chain X
6hmb chain A
6hmc chain A
6hmd chain A
6hmq chain A
6l20 chain A
6l20 chain D
6l20 chain G
6l20 chain J
6qy8 chain A
6qy8 chain B
6qy8 chain C
6qy8 chain D
6qy9 chain A
6te2 chain A
6tew chain A
6tgu chain A
7a1b chain A
7a1z chain A
7a22 chain A
7a2h chain A
7at9 chain A
7atv chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S18 RVYAEVNS LRSREYW 10 1170 114 - 90 68 9 9 81 - 68 41 93 85 97 88 61 15 101 43 89 18 S21 AEVNSLRS REYWDYE 8 325 9 - 49 31 5 4 36 - - - 10 10 39 36 - - 55 24 8 9 T252 RIAKVLGT EELYGYL 1 9 - - - - - - 9 - - - - - - - - - - - - - Y256 VLGTEELY GYLKKYH 1 9 - - - - - - 9 - - - - - - - - - - - - - Y258 GTEELYGY LKKYHID 1 18 - - - - - - 18 - - - - - - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S18 RVYAEVNS LRSREYW 3.2e-30 - 4e-8 - - 1e-14 2.8e-8 1.4e-8 0.076 4.6e-11 -9.5e-3 S21 AEVNSLRS REYWDYE 0.13 - 0.025 - - - - 0.78 - 0.94 - T252 RIAKVLGT EELYGYL - - - - - - - - - - - Y256 VLGTEELY GYLKKYH - - - - - - - - - - - Y258 GTEELYGY LKKYHID - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S18
S21
T252
Y256
Y258
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S18 S21 T252 Y256 Y258 protein RNA SCNV methylation CCRCC S18 S21 T252 Y256 Y258 protein RNA SCNV methylation COAD S18 S21 T252 Y256 Y258 protein RNA SCNV methylation GBM S18 S21 T252 Y256 Y258 protein RNA SCNV methylation HNSCC S18 S21 T252 Y256 Y258 protein RNA SCNV methylation LSCC S18 S21 T252 Y256 Y258 protein RNA SCNV methylation LUAD S18 S21 T252 Y256 Y258 protein RNA SCNV methylation OV S18 S21 T252 Y256 Y258 protein RNA SCNV methylation PDAC S18 S21 T252 Y256 Y258 protein RNA SCNV methylation UCEC S18 S21 T252 Y256 Y258 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S18
S21
T252
Y256
Y258
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S18
S21
T252
Y256
Y258
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.