Protein: ENSP00000262854

HUWE1:: HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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				BRCA		CCRCC		COAD		GBM		HNSCC		LSCC		LUAD		OV		PDAC		UCEC
Site	Sequence	Cohorts	Total	T	N	T	N	T	N	T	N	T	N	T	N	T	N	T	N	T	N	T	N
S648	PAMRRRRSSDPLGDT	10	650	25	-	29	26	56	51	72	-	6	3	59	53	70	63	17	6	23	11	62	18
S649	AMRRRRSSDPLGDTA	10	421	9	-	7	7	28	26	35	-	37	19	19	16	38	38	19	5	45	19	41	13
S718	ATAPPPRSNHAAEEA	2	18	-	-	-	-	-	-	9	-	-	-	-	-	5	4	-	-	-	-	-	-
S726	NHAAEEASSEDEEEE	7	294	7	-	-	-	52	56	27	-	10	3	23	18	18	13	-	-	-	-	62	5
S727	HAAEEASSEDEEEEE	8	711	76	-	-	-	53	51	60	-	96	49	54	42	84	64	16	-	-	-	50	16
S743	QAMQSFNSTQQNETE	4	48	9	-	-	-	9	8	7	-	-	-	-	-	8	7	-	-	-	-	-	-
T744	AMQSFNSTQQNETEP	6	55	9	-	-	-	4	4	5	-	5	4	-	-	8	7	-	-	-	-	-	9
T749	NSTQQNETEPNQQVV	1	9	-	-	-	-	5	4	-	-	-	-	-	-	-	-	-	-	-	-	-	-
S1000	EQDGAAGSMDASTQG	2	26	-	-	-	-	-	-	-	-	-	-	10	8	4	4	-	-	-	-	-	-
T1018	GIGLDGDTLAPMETD	1	9	-	-	-	-	-	-	-	-	-	-	-	-	5	4	-	-	-	-	-	-

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Tumor and normal comparison

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Site	Sequence	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
S648	PAMRRRRSSDPLGDT	-2.6e-5	-	-0.46	-0.12	-	-	-9.7e-4	-5.1e-6	-	0.59	-0.5
S649	AMRRRRSSDPLGDTA	-0.076	-	-	-1.5e-4	-	-0.19	-	-0.028	-	6.1e-4	-0.92
S718	ATAPPPRSNHAAEEA	-	-	-	-	-	-	-	-	-	-	-
S726	NHAAEEASSEDEEEE	0.11	-	-	0.042	-	-	0.83	-	-	-	-
S727	HAAEEASSEDEEEEE	1.1e-12	-	-	4.1e-3	-	2.8e-6	0.13	4.7e-5	-	-	5.8e-3
S743	QAMQSFNSTQQNETE	-	-	-	-	-	-	-	-	-	-	-
T744	AMQSFNSTQQNETEP	-	-	-	-	-	-	-	-	-	-	-
T749	NSTQQNETEPNQQVV	-	-	-	-	-	-	-	-	-	-	-
S1000	EQDGAAGSMDASTQG	-	-	-	-	-	-	-	-	-	-	-
T1018	GIGLDGDTLAPMETD	-	-	-	-	-	-	-	-	-	-	-

Showing 1 to 10 of 137 rows

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* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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			Signed p-values
Phenotype	Site	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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			Signed p-values
Kinase	Site	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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			Signed p-values
Phosphatase	Site	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Protein: ENSP00000262854Gene: HUWE1

Lollipop plot

Structure

Phosphosite detection coverage

Tumor and normal comparison

Phenotype and mutation association

Cis-association

Kinase association

Phosphatase association

Protein: ENSP00000262854
Gene: HUWE1