- MAP2K2:
- mitogen-activated protein kinase kinase 2
Lollipop plot
Phosphosites location and occurrence
Structure
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Site
| Sequence | Cohorts | Total | T | N | T | N | T | N | T | N | T | N | T | N | T | N | T | N | T | N | T | N |
T17 | PALTINPTIAEGPSP | 3 | 29 | - | - | 7 | 7 | - | - | 9 | - | - | - | - | - | - | - | - | - | - | - | 6 | - |
S23 | PTIAEGPSPTSEGAS | 10 | 1049 | 15 | - | 78 | 57 | 51 | 48 | 99 | - | 108 | 62 | 64 | 60 | 97 | 90 | 20 | 4 | 83 | 37 | 58 | 18 |
T25 | IAEGPSPTSEGASEA | 9 | 660 | 40 | - | 68 | 48 | 65 | 69 | 36 | - | 67 | 40 | 10 | 10 | 57 | 54 | - | - | 53 | 23 | 17 | 3 |
S26 | AEGPSPTSEGASEAN | 4 | 52 | - | - | 7 | 7 | - | - | 26 | - | - | - | - | - | 4 | 4 | - | - | - | - | 4 | - |
S30 | SPTSEGASEANLVDL | 7 | 139 | - | - | - | - | 6 | 3 | 37 | - | 7 | 3 | 5 | 3 | 5 | 4 | 5 | - | 42 | 19 | - | - |
S76 | DDDFERISELGAGNG | 2 | 77 | - | - | - | - | - | - | 46 | - | - | - | - | - | - | - | - | - | - | - | 29 | 2 |
S293 | GEEGEPHSISPRPRP | 7 | 403 | 38 | - | - | - | 9 | 9 | 28 | - | - | - | 74 | 67 | 84 | 77 | - | - | 3 | 2 | 12 | - |
S295 | EGEPHSISPRPRPPG | 10 | 1425 | 85 | - | 99 | 76 | 92 | 96 | 97 | - | 108 | 62 | 93 | 84 | 106 | 97 | 77 | 17 | 95 | 40 | 83 | 18 |
S306 | RPPGRPVSGHGMDSR | 10 | 1389 | 103 | - | 103 | 80 | 84 | 86 | 97 | - | 98 | 56 | 108 | 99 | 95 | 89 | 68 | 17 | 101 | 42 | 49 | 14 |
T394 | LRLNQPGTPTRTAV_ | 10 | 1553 | 122 | - | 103 | 80 | 97 | 100 | 99 | - | 108 | 62 | 108 | 99 | 110 | 101 | 83 | 19 | 105 | 44 | 95 | 18 |
Tumor and normal comparison
Site
| Sequence | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
---|---|---|---|---|---|---|---|---|---|---|---|---|
T17 | PALTINPTIAEGPSP | - | - | - | - | - | - | - | - | - | - | - |
S23 | PTIAEGPSPTSEGAS | -3.9e-17 | - | 0.47 | -1.7e-7 | - | -1.4e-17 | -4.4e-4 | -1.7e-9 | - | -0.6 | 0.4 |
T25 | IAEGPSPTSEGASEA | -4.4e-4 | - | 0.19 | -5.7e-8 | - | -1.4e-4 | - | -0.82 | - | 0.78 | - |
S26 | AEGPSPTSEGASEAN | - | - | - | - | - | - | - | - | - | - | - |
S30 | SPTSEGASEANLVDL | -0.69 | - | - | - | - | - | - | - | - | -0.69 | - |
S76 | DDDFERISELGAGNG | - | - | - | - | - | - | - | - | - | - | - |
S293 | GEEGEPHSISPRPRP | -5e-15 | - | - | - | - | - | -2.1e-10 | -2.4e-6 | - | - | - |
S295 | EGEPHSISPRPRPPG | -1.0e-5 | - | 1.8e-7 | -5.4e-7 | - | -7.3e-23 | -5.1e-5 | -0.073 | -0.9 | 0.22 | 0.055 |
S306 | RPPGRPVSGHGMDSR | -7.3e-14 | - | 1.3e-3 | -1.2e-6 | - | -1.8e-10 | -2.5e-15 | -3.3e-12 | 0.47 | 1.4e-3 | -0.029 |
T394 | LRLNQPGTPTRTAV_ | -6.1e-9 | - | -0.071 | -0.25 | - | -3.6e-6 | -3.1e-6 | -2.8e-16 | -3.4e-5 | 1.5e-10 | 0.085 |
Phenotype and mutation association
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Site | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
No matching records found |
Cis-association
Kinase association
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Kinase | Site | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
No matching records found |
Phosphatase association
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphatase | Site | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
No matching records found |