Protein: ENSP00000263209
Gene: DGCR8

LinkedOmicsKB © 2022-2023 Zhang Lab

DGCR8:
DGCR8 microprocessor complex subunit

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S35QALPREQSPPPPLQT10125390-99769710045-108629385106975287345215
S59GSGGDGQSELPAEDP2126-42----------------
S92LLIDPNCSGHSPRTA18--------------71----
S95DPNCSGHSPRTARHA106709-44565190-704015142624781585354311
S109APAVRKFSPDLKLLK934572-119729-12744413534--134414
S153AECGLLLSPVSGDVH6253------95-1271919--11333112914
S156GLLLSPVSGDVHACP82076-88--9-332120183229--11462
S167HACPFGGSVGDGVGI612842-1616--9-1365498------
S271EEKYGGDSDHPSDGE1064623-4340696518-221274673632717832225
S275GGDSDHPSDGETSVQ1075991-87141399-7541635949436915538718
Showing 1 to 10 of 18 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S35QALPREQSPPPPLQT4.1e-22--0.573.8e-3--0.48e-185e-20-7.9e-50.018
S59GSGGDGQSELPAEDP-----------
S92LLIDPNCSGHSPRTA-----------
S95DPNCSGHSPRTARHA5.1e-11--2.5e-3-1.3e-11-2.1e-50.055-5.6e-43.5e-4
S109APAVRKFSPDLKLLK4.3e-12-----2.2e-170.19---
S153AECGLLLSPVSGDVH-3.9e-3---------0.006-0.18
S156GLLLSPVSGDVHACP1.8e-3-----0.315.3e-33.1e-4---
S167HACPFGGSVGDGVGI-----------
S271EEKYGGDSDHPSDGE1e-20--0.822.4e-7-0.91.2e-164.2e-6-9e-7-
S275GGDSDHPSDGETSVQ8.5e-29----3.1e-71.6e-159.7e-50.013-5.4e-8
Showing 1 to 10 of 18 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS35S59S92S95S109S153S156S167S271S275T279S280T371S373S377S385S397S434proteinRNASCNVmethylationCCRCCS35S59S92S95S109S153S156S167S271S275T279S280T371S373S377S385S397S434proteinRNASCNVmethylationCOADS35S59S92S95S109S153S156S167S271S275T279S280T371S373S377S385S397S434proteinRNASCNVmethylationGBMS35S59S92S95S109S153S156S167S271S275T279S280T371S373S377S385S397S434proteinRNASCNVmethylationHNSCCS35S59S92S95S109S153S156S167S271S275T279S280T371S373S377S385S397S434proteinRNASCNVmethylationLSCCS35S59S92S95S109S153S156S167S271S275T279S280T371S373S377S385S397S434proteinRNASCNVmethylationLUADS35S59S92S95S109S153S156S167S271S275T279S280T371S373S377S385S397S434proteinRNASCNVmethylationOVS35S59S92S95S109S153S156S167S271S275T279S280T371S373S377S385S397S434proteinRNASCNVmethylationPDACS35S59S92S95S109S153S156S167S271S275T279S280T371S373S377S385S397S434proteinRNASCNVmethylationUCECS35S59S92S95S109S153S156S167S271S275T279S280T371S373S377S385S397S434proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.