Protein: ENSP00000263245
Gene: ARFGAP3

LinkedOmicsKB © 2022-2023 Zhang Lab

ARFGAP3:
ADP ribosylation factor GTPase activating protein 3

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S143SCVVPPLSPPPKEED8106938-10077--99-10862108998071--105446018
S212KATLEVSSIIKKKPN838870-343045----34313532711157316
S231GLGAKKGSLGAQKLA893595---191799---10898101934110104438918
S274KEESIVSSLRLAYKD934415-1312--9-634439625781432372
S314MGFGNCRSVISHSVT334--88----72--54------
T326SVTSDMQTIEQESPI2268-------117----------
S331MQTIEQESPIMAKPR1036615-44141389-24131513972061787718
S345RKKYNDDSDDSYFTS3719---------2019------167
Y349NDDSDDSYFTSSSSY22516-54----------------
S367PVELRSSSFSSWDDS8479--88394199---9998491168267718
Showing 1 to 10 of 24 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S143SCVVPPLSPPPKEED-0.098-4.3e-12--0.62-2.1e-4-0.3--7.2e-140.46
S212KATLEVSSIIKKKPN1.1e-5-0.011---0.216.5e-5--0.32
S231GLGAKKGSLGAQKLA-0.54-----0.842.4e-100.044-3.3e-6-1.4e-7
S274KEESIVSSLRLAYKD0.038------0.987.3e-15--3.2e-5-
S314MGFGNCRSVISHSVT-----------
T326SVTSDMQTIEQESPI-----------
S331MQTIEQESPIMAKPR-0.54-----0.042----0.24
S345RKKYNDDSDDSYFTS-0.51------0.51----
Y349NDDSDDSYFTSSSSY-----------
S367PVELRSSSFSSWDDS-0.47---1.5e-5----5.8e-30.120.14
Showing 1 to 10 of 24 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS143S212S231S274S314T326S331S345Y349S367S369S370S374S375S397S428S437S451S453S454S455S457S458S509proteinRNASCNVmethylationCCRCCS143S212S231S274S314T326S331S345Y349S367S369S370S374S375S397S428S437S451S453S454S455S457S458S509proteinRNASCNVmethylationCOADS143S212S231S274S314T326S331S345Y349S367S369S370S374S375S397S428S437S451S453S454S455S457S458S509proteinRNASCNVmethylationGBMS143S212S231S274S314T326S331S345Y349S367S369S370S374S375S397S428S437S451S453S454S455S457S458S509proteinRNASCNVmethylationHNSCCS143S212S231S274S314T326S331S345Y349S367S369S370S374S375S397S428S437S451S453S454S455S457S458S509proteinRNASCNVmethylationLSCCS143S212S231S274S314T326S331S345Y349S367S369S370S374S375S397S428S437S451S453S454S455S457S458S509proteinRNASCNVmethylationLUADS143S212S231S274S314T326S331S345Y349S367S369S370S374S375S397S428S437S451S453S454S455S457S458S509proteinRNASCNVmethylationOVS143S212S231S274S314T326S331S345Y349S367S369S370S374S375S397S428S437S451S453S454S455S457S458S509proteinRNASCNVmethylationPDACS143S212S231S274S314T326S331S345Y349S367S369S370S374S375S397S428S437S451S453S454S455S457S458S509proteinRNASCNVmethylationUCECS143S212S231S274S314T326S331S345Y349S367S369S370S374S375S397S428S437S451S453S454S455S457S458S509proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.