CLASP1: cytoplasmic linker associated protein 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
4k92 chain A
4k92 chain B
6mq5 chain A
6mq5 chain B
6mq7 chain A
6mq7 chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S246 KNFDDEDS VDGNRPS 10 1213 99 - 99 76 59 57 73 - 90 51 64 59 105 97 55 12 101 43 60 13 S253 SVDGNRPS SASSTSS 10 284 15 - 42 24 15 12 9 - 40 23 25 23 9 8 6 2 5 1 22 3 S254 VDGNRPSS ASSTSSK 10 294 25 - 4 4 5 4 18 - 27 16 20 18 20 19 42 9 26 9 19 9 S256 GNRPSSAS STSSKAP 6 120 6 - 4 4 - - 36 - - - 15 14 - - - - 5 2 23 11 S257 NRPSSASS TSSKAPP 3 64 - - - - - - 36 - - - - - - - - - 14 6 8 - S280 GTTRRLGS STLGSKS 10 564 32 - 42 21 15 12 37 - 28 16 15 12 54 48 28 7 95 39 58 5 S281 TTRRLGSS TLGSKSS 2 26 - - 4 4 - - 18 - - - - - - - - - - - - - S545 SHLKNSDS IVSLPQS 5 129 - - 12 12 - - 17 - - - 20 19 - - - - 16 11 18 4 S548 KNSDSIVS LPQSDRS 3 43 - - 12 12 - - 9 - - - 5 5 - - - - - - - - S555 SLPQSDRS SSSSQES 3 51 - - 5 4 - - 9 - - - - - - - - - - - 28 5
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S246 KNFDDEDS VDGNRPS 2.1e-37 - -0.003 0.092 - 7.2e-19 2.7e-15 3.6e-20 1.6e-3 4.6e-9 0.015 S253 SVDGNRPS SASSTSS 6.1e-28 - 8.8e-8 - - 7.5e-13 1e-10 - - - - S254 VDGNRPSS ASSTSSK 2.4e-24 - - - - 2.1e-7 7.1e-10 3.5e-10 - - - S256 GNRPSSAS STSSKAP 3.3e-4 - - - - - - - - - 3.3e-4 S257 NRPSSASS TSSKAPP - - - - - - - - - - - S280 GTTRRLGS STLGSKS 2.1e-9 - 0.21 - - 0.17 - 8.3e-8 - 6.6e-5 - S281 TTRRLGSS TLGSKSS - - - - - - - - - - - S545 SHLKNSDS IVSLPQS 2.1e-7 - - - - - 2.1e-7 - - - - S548 KNSDSIVS LPQSDRS - - - - - - - - - - - S555 SLPQSDRS SSSSQES - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S246
S253
S254
S256
S257
S280
S281
S545
S548
S555
S556
S557
S558
S559
S562
S568
S572
T574
S576
S582
S588
S590
S594
S598
S600
S633
Y634
S636
S646
S647
S649
T651
S676
S684
S688
S695
S704
T711
S713
S714
S723
S727
T730
S731
S795
T796
S797
T798
S823
S829
S832
S833
S836
S842
S1085
T1087
S1091
S1093
T1095
T1099
S1101
S1109
S1113
T1115
S1193
S1196
S1223
S1232
S1530
S1532
S1538
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S246 S253 S254 S256 S257 S280 S281 S545 S548 S555 S556 S557 S558 S559 S562 S568 S572 T574 S576 S582 S588 S590 S594 S598 S600 S633 Y634 S636 S646 S647 S649 T651 S676 S684 S688 S695 S704 T711 S713 S714 S723 S727 T730 S731 S795 T796 S797 T798 S823 S829 S832 S833 S836 S842 S1085 T1087 S1091 S1093 T1095 T1099 S1101 S1109 S1113 T1115 S1193 S1196 S1223 S1232 S1530 S1532 S1538 protein RNA SCNV methylation CCRCC S246 S253 S254 S256 S257 S280 S281 S545 S548 S555 S556 S557 S558 S559 S562 S568 S572 T574 S576 S582 S588 S590 S594 S598 S600 S633 Y634 S636 S646 S647 S649 T651 S676 S684 S688 S695 S704 T711 S713 S714 S723 S727 T730 S731 S795 T796 S797 T798 S823 S829 S832 S833 S836 S842 S1085 T1087 S1091 S1093 T1095 T1099 S1101 S1109 S1113 T1115 S1193 S1196 S1223 S1232 S1530 S1532 S1538 protein RNA SCNV methylation COAD S246 S253 S254 S256 S257 S280 S281 S545 S548 S555 S556 S557 S558 S559 S562 S568 S572 T574 S576 S582 S588 S590 S594 S598 S600 S633 Y634 S636 S646 S647 S649 T651 S676 S684 S688 S695 S704 T711 S713 S714 S723 S727 T730 S731 S795 T796 S797 T798 S823 S829 S832 S833 S836 S842 S1085 T1087 S1091 S1093 T1095 T1099 S1101 S1109 S1113 T1115 S1193 S1196 S1223 S1232 S1530 S1532 S1538 protein RNA SCNV methylation GBM S246 S253 S254 S256 S257 S280 S281 S545 S548 S555 S556 S557 S558 S559 S562 S568 S572 T574 S576 S582 S588 S590 S594 S598 S600 S633 Y634 S636 S646 S647 S649 T651 S676 S684 S688 S695 S704 T711 S713 S714 S723 S727 T730 S731 S795 T796 S797 T798 S823 S829 S832 S833 S836 S842 S1085 T1087 S1091 S1093 T1095 T1099 S1101 S1109 S1113 T1115 S1193 S1196 S1223 S1232 S1530 S1532 S1538 protein RNA SCNV methylation HNSCC S246 S253 S254 S256 S257 S280 S281 S545 S548 S555 S556 S557 S558 S559 S562 S568 S572 T574 S576 S582 S588 S590 S594 S598 S600 S633 Y634 S636 S646 S647 S649 T651 S676 S684 S688 S695 S704 T711 S713 S714 S723 S727 T730 S731 S795 T796 S797 T798 S823 S829 S832 S833 S836 S842 S1085 T1087 S1091 S1093 T1095 T1099 S1101 S1109 S1113 T1115 S1193 S1196 S1223 S1232 S1530 S1532 S1538 protein RNA SCNV methylation LSCC S246 S253 S254 S256 S257 S280 S281 S545 S548 S555 S556 S557 S558 S559 S562 S568 S572 T574 S576 S582 S588 S590 S594 S598 S600 S633 Y634 S636 S646 S647 S649 T651 S676 S684 S688 S695 S704 T711 S713 S714 S723 S727 T730 S731 S795 T796 S797 T798 S823 S829 S832 S833 S836 S842 S1085 T1087 S1091 S1093 T1095 T1099 S1101 S1109 S1113 T1115 S1193 S1196 S1223 S1232 S1530 S1532 S1538 protein RNA SCNV methylation LUAD S246 S253 S254 S256 S257 S280 S281 S545 S548 S555 S556 S557 S558 S559 S562 S568 S572 T574 S576 S582 S588 S590 S594 S598 S600 S633 Y634 S636 S646 S647 S649 T651 S676 S684 S688 S695 S704 T711 S713 S714 S723 S727 T730 S731 S795 T796 S797 T798 S823 S829 S832 S833 S836 S842 S1085 T1087 S1091 S1093 T1095 T1099 S1101 S1109 S1113 T1115 S1193 S1196 S1223 S1232 S1530 S1532 S1538 protein RNA SCNV methylation OV S246 S253 S254 S256 S257 S280 S281 S545 S548 S555 S556 S557 S558 S559 S562 S568 S572 T574 S576 S582 S588 S590 S594 S598 S600 S633 Y634 S636 S646 S647 S649 T651 S676 S684 S688 S695 S704 T711 S713 S714 S723 S727 T730 S731 S795 T796 S797 T798 S823 S829 S832 S833 S836 S842 S1085 T1087 S1091 S1093 T1095 T1099 S1101 S1109 S1113 T1115 S1193 S1196 S1223 S1232 S1530 S1532 S1538 protein RNA SCNV methylation PDAC S246 S253 S254 S256 S257 S280 S281 S545 S548 S555 S556 S557 S558 S559 S562 S568 S572 T574 S576 S582 S588 S590 S594 S598 S600 S633 Y634 S636 S646 S647 S649 T651 S676 S684 S688 S695 S704 T711 S713 S714 S723 S727 T730 S731 S795 T796 S797 T798 S823 S829 S832 S833 S836 S842 S1085 T1087 S1091 S1093 T1095 T1099 S1101 S1109 S1113 T1115 S1193 S1196 S1223 S1232 S1530 S1532 S1538 protein RNA SCNV methylation UCEC S246 S253 S254 S256 S257 S280 S281 S545 S548 S555 S556 S557 S558 S559 S562 S568 S572 T574 S576 S582 S588 S590 S594 S598 S600 S633 Y634 S636 S646 S647 S649 T651 S676 S684 S688 S695 S704 T711 S713 S714 S723 S727 T730 S731 S795 T796 S797 T798 S823 S829 S832 S833 S836 S842 S1085 T1087 S1091 S1093 T1095 T1099 S1101 S1109 S1113 T1115 S1193 S1196 S1223 S1232 S1530 S1532 S1538 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S246
S253
S254
S256
S257
S280
S281
S545
S548
S555
S556
S557
S558
S559
S562
S568
S572
T574
S576
S582
S588
S590
S594
S598
S600
S633
Y634
S636
S646
S647
S649
T651
S676
S684
S688
S695
S704
T711
S713
S714
S723
S727
T730
S731
S795
T796
S797
T798
S823
S829
S832
S833
S836
S842
S1085
T1087
S1091
S1093
T1095
T1099
S1101
S1109
S1113
T1115
S1193
S1196
S1223
S1232
S1530
S1532
S1538
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S246
S253
S254
S256
S257
S280
S281
S545
S548
S555
S556
S557
S558
S559
S562
S568
S572
T574
S576
S582
S588
S590
S594
S598
S600
S633
Y634
S636
S646
S647
S649
T651
S676
S684
S688
S695
S704
T711
S713
S714
S723
S727
T730
S731
S795
T796
S797
T798
S823
S829
S832
S833
S836
S842
S1085
T1087
S1091
S1093
T1095
T1099
S1101
S1109
S1113
T1115
S1193
S1196
S1223
S1232
S1530
S1532
S1538
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.