Protein: ENSP00000263847
Gene: OSBP

LinkedOmicsKB © 2022-2023 Zhang Lab

OSBP:
oxysterol binding protein

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S190AVKMLAESDESGDEE1085599-3130252090-41246459847525748209518
S193MLAESDESGDEESVS101517113-10380818999-10862108991101018319105449518
S198DESGDEESVSQTDKT711118-88----5354232062---9
S200SGDEESVSQTDKTEL46515---------541312----115
S215QNTLRTLSSKVEDLS18------------------8-
T223SKVEDLSTCNDLIAK215--44--------------7-
T233DLIAKHGTALQRSLS18--------------71----
S238HGTALQRSLSELESL1091426-2924776790-794759543128491092399518
S240TALQRSLSELESLKL101493106-94729710099-10259108991101016717105449518
S244RSLSELESLKLPAES36425-2012----52----------
Showing 1 to 10 of 23 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S190AVKMLAESDESGDEE1e-18--3.5e-51.9e-6-1e-71.1e-101.7e-12--0.0152.2e-10
S193MLAESDESGDEESVS2.8e-13--5.8e-140.029-1.5e-141.9e-123.1e-16-0.78-5.8e-39.1e-10
S198DESGDEESVSQTDKT0.19------0.19---
S200SGDEESVSQTDKTEL-----------
S215QNTLRTLSSKVEDLS-----------
T223SKVEDLSTCNDLIAK-----------
T233DLIAKHGTALQRSLS-----------
S238HGTALQRSLSELESL0.6--0.0880.72--0.0183.2e-4-0.46-0.0770.564.2e-4
S240TALQRSLSELESLKL2.8e-23--0.111.3e-13-8.9e-72e-232e-150.35-2.2e-55.7e-3
S244RSLSELESLKLPAES-0.27--0.27--------
Showing 1 to 10 of 23 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS190S193S198S200S215T223T233S238S240S244S287T332S338S345S351T367T377S379S382S385S386S389S802proteinRNASCNVmethylationCCRCCS190S193S198S200S215T223T233S238S240S244S287T332S338S345S351T367T377S379S382S385S386S389S802proteinRNASCNVmethylationCOADS190S193S198S200S215T223T233S238S240S244S287T332S338S345S351T367T377S379S382S385S386S389S802proteinRNASCNVmethylationGBMS190S193S198S200S215T223T233S238S240S244S287T332S338S345S351T367T377S379S382S385S386S389S802proteinRNASCNVmethylationHNSCCS190S193S198S200S215T223T233S238S240S244S287T332S338S345S351T367T377S379S382S385S386S389S802proteinRNASCNVmethylationLSCCS190S193S198S200S215T223T233S238S240S244S287T332S338S345S351T367T377S379S382S385S386S389S802proteinRNASCNVmethylationLUADS190S193S198S200S215T223T233S238S240S244S287T332S338S345S351T367T377S379S382S385S386S389S802proteinRNASCNVmethylationOVS190S193S198S200S215T223T233S238S240S244S287T332S338S345S351T367T377S379S382S385S386S389S802proteinRNASCNVmethylationPDACS190S193S198S200S215T223T233S238S240S244S287T332S338S345S351T367T377S379S382S385S386S389S802proteinRNASCNVmethylationUCECS190S193S198S200S215T223T233S238S240S244S287T332S338S345S351T367T377S379S382S385S386S389S802proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.