KDR: kinase insert domain receptor
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1vr2 chain A
1y6a chain A
1y6b chain A
1ywn chain A
2m59 chain A
2m59 chain B
2met chain A
2met chain B
2met chain C
2meu chain A
2meu chain B
2oh4 chain A
2p2h chain A
2p2i chain A
2p2i chain B
2qu5 chain A
2qu6 chain A
2qu6 chain B
2rl5 chain A
2x1w chain L
2x1w chain M
2x1w chain N
2x1w chain O
2x1x chain R
2xir chain A
3b8q chain A
3b8q chain B
3b8r chain A
3b8r chain B
3be2 chain A
3c7q chain A
3cjf chain A
3cjg chain A
3cp9 chain A
3cp9 chain B
3cpb chain A
3cpb chain B
3cpc chain A
3cpc chain B
3dtw chain A
3dtw chain B
3efl chain A
3efl chain B
3ewh chain A
3kvq chain A
3s35 chain X
3s36 chain X
3s37 chain X
3u6j chain A
3v2a chain R
3v6b chain R
3vhe chain A
3vhk chain A
3vid chain A
3vnt chain A
3vo3 chain A
3wzd chain A
3wze chain A
4ag8 chain A
4agc chain A
4agd chain A
4asd chain A
4ase chain A
5ew3 chain A
5ew3 chain B
5oyj chain C
5oyj chain D
6gqo chain A
6gqp chain A
6gqq chain A
6xvj chain A
6xvk chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
Y224 VVVGYRIY DVVLSPS 1 7 - - - - - - - - - - - - - - - - - - 5 2 Y951 RFRQGKDY VGAIPVD 1 8 - - 4 4 - - - - - - - - - - - - - - - - S982 SGFVEEKS LSDVEEE 3 31 - - 8 8 - - - - - - - - 4 4 - - - - 5 2 S984 FVEEKSLS DVEEEEA 3 98 - - - - - - - - - - 35 32 13 12 - - - - 6 - Y1214 VCDPKFHY DNTAGIS 1 8 - - 4 4 - - - - - - - - - - - - - - - - Y1223 NTAGISQY LQNSKRK 1 9 - - - - - - - - - - - - 5 4 - - - - - - S1227 ISQYLQNS KRKSRPV 1 9 - - - - - - - - - - - - - - - - - - - 9 S1231 LQNSKRKS RPVSVKT 4 126 - - 36 27 - - - - - - 15 14 9 8 - - - - 5 12 S1235 KRKSRPVS VKTFEDI 5 221 - - 71 49 - - - - - - 25 23 9 8 - - 9 2 11 14 T1238 SRPVSVKT FEDIPLE 4 210 - - 71 49 - - - - - - 25 23 9 8 - - - - 11 14
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Y224 VVVGYRIY DVVLSPS - - - - - - - - - - - Y951 RFRQGKDY VGAIPVD - - - - - - - - - - - S982 SGFVEEKS LSDVEEE - - - - - - - - - - - S984 FVEEKSLS DVEEEEA -2.8e-7 - - - - - -2.8e-7 - - - - Y1214 VCDPKFHY DNTAGIS - - - - - - - - - - - Y1223 NTAGISQY LQNSKRK - - - - - - - - - - - S1227 ISQYLQNS KRKSRPV - - - - - - - - - - - S1231 LQNSKRKS RPVSVKT 5.0e-6 - 5.0e-6 - - - - - - - - S1235 KRKSRPVS VKTFEDI -0.2 - 1.6e-4 - - - -2.3e-8 - - - - T1238 SRPVSVKT FEDIPLE -0.2 - 1.6e-4 - - - -2.3e-8 - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
Y224
Y951
S982
S984
Y1214
Y1223
S1227
S1231
S1235
T1238
S1260
S1266
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA Y224 Y951 S982 S984 Y1214 Y1223 S1231 S1235 T1238 S1260 S1266 protein RNA SCNV methylation CCRCC Y224 Y951 S982 S984 Y1214 Y1223 S1231 S1235 T1238 S1260 S1266 protein RNA SCNV methylation COAD Y224 Y951 S982 S984 Y1214 Y1223 S1231 S1235 T1238 S1260 S1266 protein RNA SCNV methylation GBM Y224 Y951 S982 S984 Y1214 Y1223 S1231 S1235 T1238 S1260 S1266 protein RNA SCNV methylation HNSCC Y224 Y951 S982 S984 Y1214 Y1223 S1231 S1235 T1238 S1260 S1266 protein RNA SCNV methylation LSCC Y224 Y951 S982 S984 Y1214 Y1223 S1231 S1235 T1238 S1260 S1266 protein RNA SCNV methylation LUAD Y224 Y951 S982 S984 Y1214 Y1223 S1231 S1235 T1238 S1260 S1266 protein RNA SCNV methylation OV Y224 Y951 S982 S984 Y1214 Y1223 S1231 S1235 T1238 S1260 S1266 protein RNA SCNV methylation PDAC Y224 Y951 S982 S984 Y1214 Y1223 S1231 S1235 T1238 S1260 S1266 protein RNA SCNV methylation UCEC Y224 Y951 S982 S984 Y1214 Y1223 S1231 S1235 T1238 S1260 S1266 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
Y224
Y951
S982
S984
Y1214
Y1223
S1227
S1231
S1235
T1238
S1260
S1266
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
Y224
Y951
S982
S984
Y1214
Y1223
S1227
S1231
S1235
T1238
S1260
S1266
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.