PIK3CA: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2enq chain A
2rd0 chain A
3hhm chain A
3hiz chain A
3zim chain A
4jps chain A
4l1b chain A
4l23 chain A
4l2y chain A
4ovu chain A
4ovv chain A
4tuu chain A
4tv3 chain A
4waf chain A
4ykn chain A
4zop chain A
5dxh chain A
5dxh chain D
5dxt chain A
5fi4 chain A
5itd chain A
5sw8 chain A
5swg chain A
5swo chain A
5swp chain A
5swr chain A
5swt chain A
5sx8 chain A
5sx9 chain A
5sxa chain A
5sxb chain A
5sxc chain A
5sxd chain A
5sxe chain A
5sxf chain A
5sxi chain A
5sxj chain A
5sxk chain A
5ubr chain A
5uk8 chain A
5ukj chain A
5ul1 chain A
5xgh chain A
5xgi chain A
5xgj chain A
6gvf chain A
6gvg chain A
6gvh chain A
6gvi chain A
6nct chain A
6oac chain A
6pys chain A
6vo7 chain A
7jiu chain A
7k6m chain A
7k6n chain A
7k6o chain A
7k71 chain A
7l1b chain C
7l1c chain C
7l1d chain C
7mlk chain A
7myn chain A
7myo chain A
7pg5 chain A
7pg6 chain A
7r9v chain A
7r9y chain A
7rrg chain C
7tz7 chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S158 VDLRDLNS PHSRAMY 2 26 - - - - - - 9 - - - - - - - 12 5 - - - - S292 LMLMAKES LYSQLPM 1 6 - - - - - - - - - - - - - - - - 5 1 - - S312 PSYSRRIS TATPYMN 10 726 39 - 12 4 17 19 99 - 23 15 64 57 48 45 51 10 90 38 77 18 T313 SYSRRIST ATPYMNG 3 26 - - - - - - - - 6 3 5 4 4 4 - - - - - - T315 SRRISTAT PYMNGET 2 18 - - - - - - - - 4 4 5 5 - - - - - - - - Y317 RISTATPY MNGETST 3 34 9 - 8 8 - - - - - - - - 5 4 - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S158 VDLRDLNS PHSRAMY - - - - - - - - - - - S292 LMLMAKES LYSQLPM - - - - - - - - - - - S312 PSYSRRIS TATPYMN -0.091 - - - - 0.93 -0.032 -1.6e-5 0.063 6.7e-4 -2.4e-3 T313 SYSRRIST ATPYMNG - - - - - - - - - - - T315 SRRISTAT PYMNGET - - - - - - - - - - - Y317 RISTATPY MNGETST - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S158
S292
S312
T313
T315
Y317
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S158 S292 S312 T313 T315 Y317 protein RNA SCNV methylation CCRCC S158 S292 S312 T313 T315 Y317 protein RNA SCNV methylation COAD S158 S292 S312 T313 T315 Y317 protein RNA SCNV methylation GBM S158 S292 S312 T313 T315 Y317 protein RNA SCNV methylation HNSCC S158 S292 S312 T313 T315 Y317 protein RNA SCNV methylation LSCC S158 S292 S312 T313 T315 Y317 protein RNA SCNV methylation LUAD S158 S292 S312 T313 T315 Y317 protein RNA SCNV methylation OV S158 S292 S312 T313 T315 Y317 protein RNA SCNV methylation PDAC S158 S292 S312 T313 T315 Y317 protein RNA SCNV methylation UCEC S158 S292 S312 T313 T315 Y317 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S158
S292
S312
T313
T315
Y317
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S158
S292
S312
T313
T315
Y317
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.