Protein: ENSP00000264126
Gene: GPSM2

LinkedOmicsKB © 2022-2023 Zhang Lab

GPSM2:
G protein signaling modulator 2

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S408PKLGRRHSMENMELM9103956-7452665999-10862786910696--683169
T418NMELMKLTPEKVQNW11414-------------------
S470VLQDASNSIDHRIPN19------9-------------
S483PNSQRKISADTIGDE590----141336-73------4193
T486QRKISADTIGDEGFF217--44--------54------
T523CHTASTTTSSTPPKM166-------------------
S525TASTTTSSTPPKMML216--------53----62----
T526ASTTTSSTPPKMMLK4153------81-63----368--109
S536KMMLKTSSVPVVSPN6427----705635-734330274539----72
S541TSSVPVVSPNTDEFL81957---252018-43252018444---52
Showing 1 to 10 of 11 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S408PKLGRRHSMENMELM1.6e-8-1e-81.8e-6--0.0820.320.54-5.6e-4-
T418NMELMKLTPEKVQNW-----------
S470VLQDASNSIDHRIPN-----------
S483PNSQRKISADTIGDE-----------
T486QRKISADTIGDEGFF-----------
T523CHTASTTTSSTPPKM-----------
S525TASTTTSSTPPKMML-----------
T526ASTTTSSTPPKMMLK-----------
S536KMMLKTSSVPVVSPN-0.44---0.79--0.53-0.69-0.8---
S541TSSVPVVSPNTDEFL-0.16---0.069--0.0140.067----
Showing 1 to 10 of 11 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
KINASE-PSP_AurB/AURKBS5653.7e-13---0.0172.9e-90.0513.7e-4--0.016
KINASE-PSP_Chk1/CHEK1S5656.7e-9--0.0210.340.356.3e-37.7e-40.033-3.6e-3
HALLMARK_E2F_TARGETST5263.9e-8---4.4e-6---0.019-9.8e-3
HALLMARK_G2M_CHECKPOINTT5265e-8---6.9e-6---0.013-0.014
HALLMARK_G2M_CHECKPOINTS4089.3e-81.1e-40.011-0.783.9e-4-0.90.0460.21-0.021-
HALLMARK_E2F_TARGETSS4081.3e-74.2e-40.018-0.672.7e-4-0.730.0360.098-0.016-
PERT-PSP_EGFS5652.4e-70.075-0.182.9e-30.0210.0540.0490.47-0.11
KINASE-PSP_PKACA/PRKACAS5654.9e-70.16--0.0860.0066.1e-50.0861.9e-5-0.69-0.03
chromosomal instabilityS4089e-73.4e-41.9e-30.0192.1e-3-0.180.180.27-0.49-
KINASE-PSP_CDK2S4081.8e-63.6e-40.049-0.78.3e-40.970.0270.4-0.055-
Showing 1 to 10 of 2838 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS408T418S470S483T486T523S525T526S536S541S565proteinRNASCNVmethylationCCRCCS408T418S470S483T486T523S525T526S536S541S565proteinRNASCNVmethylationCOADS408T418S470S483T486T523S525T526S536S541S565proteinRNASCNVmethylationGBMS408T418S470S483T486T523S525T526S536S541S565proteinRNASCNVmethylationHNSCCS408T418S470S483T486T523S525T526S536S541S565proteinRNASCNVmethylationLSCCS408T418S470S483T486T523S525T526S536S541S565proteinRNASCNVmethylationLUADS408T418S470S483T486T523S525T526S536S541S565proteinRNASCNVmethylationOVS408T418S470S483T486T523S525T526S536S541S565proteinRNASCNVmethylationPDACS408T418S470S483T486T523S525T526S536S541S565proteinRNASCNVmethylationUCECS408T418S470S483T486T523S525T526S536S541S565proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
TRIM33S4082.9e-140.0190.084-0.772.2e-16-0.591.2e-47.5e-6-0.083-
CDK1S4081e-101.1e-42.1e-5-0.851.5e-4-0.570.0110.07-5.5e-3-
AURKBT5263e-9---4.7e-5---4.8e-4-6.8e-3
CDK1T5261.7e-7---1.3e-4---9.4e-4-0.054
CDK13T5263.3e-7---3.8e-5---7.2e-4-0.18
PBKT5265.2e-7---9.8e-5---0.015-0.018
RPS6KA3S5655.4e-70.022-4.4e-30.18-0.460.163.2e-30.01-0.13
PRKDCS4081.7e-60.526.9e-40.121.4e-6-0.0340.120.65-1.2e-3-
MAP3K6S5653.8e-60.059-0.60.320.0930.0270.0670.037-0.063
SMG1S4084.6e-6-0.750.073-0.111.3e-41.7e-31.4e-60.17--0.91-
Showing 1 to 10 of 5918 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
FBP1S408-7.1e-7-5.7e-3-2.2e-30.59-7.7e-5-0.014-0.0420.61--0.42-
DUSP3S408-5.1e-6-0.079-0.024-0.99-4.6e-40.24-3.7e-3-0.11--0.043-
PHPT1S408-1.1e-5-4.7e-3-0.0290.044-0.72-0.28-0.036-5.4e-3--1.8e-3-
TNS2S408-1.3e-5-0.003-0.0170.87-0.03-0.062-0.36-0.23--0.33-
TNS3S408-7.4e-50.58-0.670.58-1.3e-5-1.3e-5-0.0340.33--0.043-
IMPA1T526-8.0e-5----5.2e-3----0.083--0.021
PHPT1S565-1.5e-4-0.081--0.890.71-0.77-0.26-0.19-9.3e-4--1.6e-3
PNKPS565-1.7e-4-0.56-0.17-2.6e-4-5.7e-4-0.26-0.1-0.024-0.49
G6PCS408-2.0e-4--2.0e-4--------
CTDNEP1S541-2.2e-4----0.081-6.3e-3-0.056----
Showing 1 to 10 of 2640 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.