TOP2B: DNA topoisomerase II beta
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
3qx3 chain A
3qx3 chain B
4g0u chain A
4g0u chain B
4g0v chain A
4g0v chain B
4g0w chain A
4g0w chain B
4j3n chain A
4j3n chain B
5gwi chain A
5gwi chain B
5gwj chain A
5gwj chain B
5zad chain A
5zad chain B
5zen chain A
5zqf chain A
5zrf chain A
5zrf chain B
7qfn chain A
7qfo chain A
7zbg chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S37 NAAKKEES ETANKND 1 9 - - - - - - - - - - - - - - - - - - - 9 S1132 QNQHDDSS SDSGTPS 3 34 - - - - 6 3 17 - - - - - - - - - - - 5 3 S1133 NQHDDSSS DSGTPSG 3 34 - - - - 6 3 17 - - - - - - - - - - - 5 3 T1137 DSSSDSGT PSGPDFN 1 9 - - - - 5 4 - - - - - - - - - - - - - - S1139 SSDSGTPS GPDFNYI 1 9 - - - - 5 4 - - - - - - - - - - - - - - Y1145 PSGPDFNY ILNMSLW 3 70 15 - 24 22 4 5 - - - - - - - - - - - - - - S1150 FNYILNMS LWSLTKE 1 9 - - 5 4 - - - - - - - - - - - - - - - - S1236 QLEETMPS PYGRRII 7 368 81 - - - - - 9 - 18 9 25 21 30 27 41 10 - - 79 18 S1279 VEFDEEFS GAPVEGA 7 372 70 - 12 11 - - 44 - 21 13 64 58 19 16 - - - - 28 16 T1292 GAGEEALT PSVPINK 10 1341 122 - 103 80 42 39 98 - 108 62 103 95 101 94 39 6 100 42 89 18
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S37 NAAKKEES ETANKND - - - - - - - - - - - S1132 QNQHDDSS SDSGTPS - - - - - - - - - - - S1133 NQHDDSSS DSGTPSG - - - - - - - - - - - T1137 DSSSDSGT PSGPDFN - - - - - - - - - - - S1139 SSDSGTPS GPDFNYI - - - - - - - - - - - Y1145 PSGPDFNY ILNMSLW -4.3e-3 - -4.3e-3 - - - - - - - - S1150 FNYILNMS LWSLTKE - - - - - - - - - - - S1236 QLEETMPS PYGRRII 6.7e-10 - - - - - 4.1e-5 8.2e-3 0.37 - 2.6e-6 S1279 VEFDEEFS GAPVEGA -1.6e-4 - - - - -4.0e-4 0.82 - - - -1.2e-3 T1292 GAGEEALT PSVPINK -4.5e-16 - -2.1e-11 -0.031 - -1.4e-10 -5.9e-4 0.5 - -3.7e-5 0.5
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S37
S1132
S1133
T1137
S1139
Y1145
S1150
S1236
S1279
T1292
T1317
T1319
S1320
S1336
S1340
S1342
S1344
S1358
T1371
S1375
S1400
T1403
S1413
Y1421
T1422
S1424
T1431
S1441
S1449
S1452
Y1453
S1454
S1457
S1461
S1466
S1471
S1473
S1476
S1500
S1501
S1522
S1524
S1526
S1550
S1552
T1575
S1576
S1581
S1588
S1596
S1613
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S1132 S1133 T1137 S1139 Y1145 S1150 S1236 S1279 T1292 T1317 T1319 S1320 S1336 S1340 S1342 S1344 S1358 T1371 S1375 S1400 T1403 S1413 Y1421 T1422 S1424 T1431 S1441 S1449 S1452 Y1453 S1454 S1457 S1461 S1466 S1471 S1473 S1476 S1500 S1501 S1522 S1524 S1526 S1550 S1552 T1575 S1576 S1581 S1588 S1596 S1613 protein RNA SCNV methylation CCRCC S1132 S1133 T1137 S1139 Y1145 S1150 S1236 S1279 T1292 T1317 T1319 S1320 S1336 S1340 S1342 S1344 S1358 T1371 S1375 S1400 T1403 S1413 Y1421 T1422 S1424 T1431 S1441 S1449 S1452 Y1453 S1454 S1457 S1461 S1466 S1471 S1473 S1476 S1500 S1501 S1522 S1524 S1526 S1550 S1552 T1575 S1576 S1581 S1588 S1596 S1613 protein RNA SCNV methylation COAD S1132 S1133 T1137 S1139 Y1145 S1150 S1236 S1279 T1292 T1317 T1319 S1320 S1336 S1340 S1342 S1344 S1358 T1371 S1375 S1400 T1403 S1413 Y1421 T1422 S1424 T1431 S1441 S1449 S1452 Y1453 S1454 S1457 S1461 S1466 S1471 S1473 S1476 S1500 S1501 S1522 S1524 S1526 S1550 S1552 T1575 S1576 S1581 S1588 S1596 S1613 protein RNA SCNV methylation GBM S1132 S1133 T1137 S1139 Y1145 S1150 S1236 S1279 T1292 T1317 T1319 S1320 S1336 S1340 S1342 S1344 S1358 T1371 S1375 S1400 T1403 S1413 Y1421 T1422 S1424 T1431 S1441 S1449 S1452 Y1453 S1454 S1457 S1461 S1466 S1471 S1473 S1476 S1500 S1501 S1522 S1524 S1526 S1550 S1552 T1575 S1576 S1581 S1588 S1596 S1613 protein RNA SCNV methylation HNSCC S1132 S1133 T1137 S1139 Y1145 S1150 S1236 S1279 T1292 T1317 T1319 S1320 S1336 S1340 S1342 S1344 S1358 T1371 S1375 S1400 T1403 S1413 Y1421 T1422 S1424 T1431 S1441 S1449 S1452 Y1453 S1454 S1457 S1461 S1466 S1471 S1473 S1476 S1500 S1501 S1522 S1524 S1526 S1550 S1552 T1575 S1576 S1581 S1588 S1596 S1613 protein RNA SCNV methylation LSCC S1132 S1133 T1137 S1139 Y1145 S1150 S1236 S1279 T1292 T1317 T1319 S1320 S1336 S1340 S1342 S1344 S1358 T1371 S1375 S1400 T1403 S1413 Y1421 T1422 S1424 T1431 S1441 S1449 S1452 Y1453 S1454 S1457 S1461 S1466 S1471 S1473 S1476 S1500 S1501 S1522 S1524 S1526 S1550 S1552 T1575 S1576 S1581 S1588 S1596 S1613 protein RNA SCNV methylation LUAD S1132 S1133 T1137 S1139 Y1145 S1150 S1236 S1279 T1292 T1317 T1319 S1320 S1336 S1340 S1342 S1344 S1358 T1371 S1375 S1400 T1403 S1413 Y1421 T1422 S1424 T1431 S1441 S1449 S1452 Y1453 S1454 S1457 S1461 S1466 S1471 S1473 S1476 S1500 S1501 S1522 S1524 S1526 S1550 S1552 T1575 S1576 S1581 S1588 S1596 S1613 protein RNA SCNV methylation OV S1132 S1133 T1137 S1139 Y1145 S1150 S1236 S1279 T1292 T1317 T1319 S1320 S1336 S1340 S1342 S1344 S1358 T1371 S1375 S1400 T1403 S1413 Y1421 T1422 S1424 T1431 S1441 S1449 S1452 Y1453 S1454 S1457 S1461 S1466 S1471 S1473 S1476 S1500 S1501 S1522 S1524 S1526 S1550 S1552 T1575 S1576 S1581 S1588 S1596 S1613 protein RNA SCNV methylation PDAC S1132 S1133 T1137 S1139 Y1145 S1150 S1236 S1279 T1292 T1317 T1319 S1320 S1336 S1340 S1342 S1344 S1358 T1371 S1375 S1400 T1403 S1413 Y1421 T1422 S1424 T1431 S1441 S1449 S1452 Y1453 S1454 S1457 S1461 S1466 S1471 S1473 S1476 S1500 S1501 S1522 S1524 S1526 S1550 S1552 T1575 S1576 S1581 S1588 S1596 S1613 protein RNA SCNV methylation UCEC S1132 S1133 T1137 S1139 Y1145 S1150 S1236 S1279 T1292 T1317 T1319 S1320 S1336 S1340 S1342 S1344 S1358 T1371 S1375 S1400 T1403 S1413 Y1421 T1422 S1424 T1431 S1441 S1449 S1452 Y1453 S1454 S1457 S1461 S1466 S1471 S1473 S1476 S1500 S1501 S1522 S1524 S1526 S1550 S1552 T1575 S1576 S1581 S1588 S1596 S1613 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S37
S1132
S1133
T1137
S1139
Y1145
S1150
S1236
S1279
T1292
T1317
T1319
S1320
S1336
S1340
S1342
S1344
S1358
T1371
S1375
S1400
T1403
S1413
Y1421
T1422
S1424
T1431
S1441
S1449
S1452
Y1453
S1454
S1457
S1461
S1466
S1471
S1473
S1476
S1500
S1501
S1522
S1524
S1526
S1550
S1552
T1575
S1576
S1581
S1588
S1596
S1613
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S37
S1132
S1133
T1137
S1139
Y1145
S1150
S1236
S1279
T1292
T1317
T1319
S1320
S1336
S1340
S1342
S1344
S1358
T1371
S1375
S1400
T1403
S1413
Y1421
T1422
S1424
T1431
S1441
S1449
S1452
Y1453
S1454
S1457
S1461
S1466
S1471
S1473
S1476
S1500
S1501
S1522
S1524
S1526
S1550
S1552
T1575
S1576
S1581
S1588
S1596
S1613
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.