PIKFYVE: phosphoinositide kinase, FYVE-type zinc finger containing
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
7k2v chain A
7k2v chain P
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S8 MATDDKTS PTLDSAN 2 17 - - 4 4 - - 9 - - - - - - - - - - - - - S20 SANDLPRS PTSPSHL 2 99 - - - - - - 89 - 6 4 - - - - - - - - - - S23 DLPRSPTS PSHLTHF 1 35 - - - - - - 35 - - - - - - - - - - - - - T34 LTHFKPLT PDQDEPP 1 6 - - - - - - - - - - - - - - - - - - 6 - S48 PFKSAYSS FVNLFRF 7 315 39 - - - 10 8 - - 22 16 88 82 9 8 12 4 - - 6 11 S73 EQQPLSGS WTSPQLP 1 8 - - - - - - - - - - - - - - - - - - 6 2 T75 QPLSGSWT SPQLPSR 1 9 - - - - - - - - - - - - - - 7 2 - - - - S85 QLPSRTQS VRSPTPY 2 32 8 - - - - - - - - - - - - - - - - - 22 2 S88 SRTQSVRS PTPYKKQ 9 957 113 - 73 53 - - 82 - 51 30 98 90 69 65 19 5 71 33 87 18 S105 EELQRRSS ALDTRRK 10 1242 82 - 71 50 83 87 99 - 74 44 89 83 84 78 75 18 82 36 89 18
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S8 MATDDKTS PTLDSAN - - - - - - - - - - - S20 SANDLPRS PTSPSHL - - - - - - - - - - - S23 DLPRSPTS PSHLTHF - - - - - - - - - - - T34 LTHFKPLT PDQDEPP - - - - - - - - - - - S48 PFKSAYSS FVNLFRF 2.5e-10 - - - - 0.021 3.3e-11 - - - - S73 EQQPLSGS WTSPQLP - - - - - - - - - - - T75 QPLSGSWT SPQLPSR - - - - - - - - - - - S85 QLPSRTQS VRSPTPY - - - - - - - - - - - S88 SRTQSVRS PTPYKKQ -0.021 - 6.9e-10 - - -2.5e-3 -2.5e-6 -1.5e-5 - -0.71 0.53 S105 EELQRRSS ALDTRRK 1.6e-14 - 3.5e-10 2.7e-3 - 1.5e-14 -0.13 0.22 3.5e-5 4.6e-9 -6.2e-7
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S8
S20
S23
T34
S48
S73
T75
S85
S88
S105
T253
S291
S299
S307
T309
S312
S316
S318
S329
T341
T447
S449
S452
S454
S457
S475
T477
S491
S493
S1111
T1479
S1522
S1526
S1544
S1549
S1695
S1714
S1741
S1754
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S8 S20 S23 T34 S48 S73 T75 S85 S88 S105 T253 S291 S299 S307 T309 S312 S316 S318 S329 T341 T447 S449 S452 S454 S457 S475 T477 S491 S493 S1111 T1479 S1522 S1526 S1544 S1549 S1695 S1714 S1741 S1754 protein RNA SCNV methylation CCRCC S8 S20 S23 T34 S48 S73 T75 S85 S88 S105 T253 S291 S299 S307 T309 S312 S316 S318 S329 T341 T447 S449 S452 S454 S457 S475 T477 S491 S493 S1111 T1479 S1522 S1526 S1544 S1549 S1695 S1714 S1741 S1754 protein RNA SCNV methylation COAD S8 S20 S23 T34 S48 S73 T75 S85 S88 S105 T253 S291 S299 S307 T309 S312 S316 S318 S329 T341 T447 S449 S452 S454 S457 S475 T477 S491 S493 S1111 T1479 S1522 S1526 S1544 S1549 S1695 S1714 S1741 S1754 protein RNA SCNV methylation GBM S8 S20 S23 T34 S48 S73 T75 S85 S88 S105 T253 S291 S299 S307 T309 S312 S316 S318 S329 T341 T447 S449 S452 S454 S457 S475 T477 S491 S493 S1111 T1479 S1522 S1526 S1544 S1549 S1695 S1714 S1741 S1754 protein RNA SCNV methylation HNSCC S8 S20 S23 T34 S48 S73 T75 S85 S88 S105 T253 S291 S299 S307 T309 S312 S316 S318 S329 T341 T447 S449 S452 S454 S457 S475 T477 S491 S493 S1111 T1479 S1522 S1526 S1544 S1549 S1695 S1714 S1741 S1754 protein RNA SCNV methylation LSCC S8 S20 S23 T34 S48 S73 T75 S85 S88 S105 T253 S291 S299 S307 T309 S312 S316 S318 S329 T341 T447 S449 S452 S454 S457 S475 T477 S491 S493 S1111 T1479 S1522 S1526 S1544 S1549 S1695 S1714 S1741 S1754 protein RNA SCNV methylation LUAD S8 S20 S23 T34 S48 S73 T75 S85 S88 S105 T253 S291 S299 S307 T309 S312 S316 S318 S329 T341 T447 S449 S452 S454 S457 S475 T477 S491 S493 S1111 T1479 S1522 S1526 S1544 S1549 S1695 S1714 S1741 S1754 protein RNA SCNV methylation OV S8 S20 S23 T34 S48 S73 T75 S85 S88 S105 T253 S291 S299 S307 T309 S312 S316 S318 S329 T341 T447 S449 S452 S454 S457 S475 T477 S491 S493 S1111 T1479 S1522 S1526 S1544 S1549 S1695 S1714 S1741 S1754 protein RNA SCNV methylation PDAC S8 S20 S23 T34 S48 S73 T75 S85 S88 S105 T253 S291 S299 S307 T309 S312 S316 S318 S329 T341 T447 S449 S452 S454 S457 S475 T477 S491 S493 S1111 T1479 S1522 S1526 S1544 S1549 S1695 S1714 S1741 S1754 protein RNA SCNV methylation UCEC S8 S20 S23 T34 S48 S73 T75 S85 S88 S105 T253 S291 S299 S307 T309 S312 S316 S318 S329 T341 T447 S449 S452 S454 S457 S475 T477 S491 S493 S1111 T1479 S1522 S1526 S1544 S1549 S1695 S1714 S1741 S1754 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S8
S20
S23
T34
S48
S73
T75
S85
S88
S105
T253
S291
S299
S307
T309
S312
S316
S318
S329
T341
T447
S449
S452
S454
S457
S475
T477
S491
S493
S1111
T1479
S1522
S1526
S1544
S1549
S1695
S1714
S1741
S1754
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S8
S20
S23
T34
S48
S73
T75
S85
S88
S105
T253
S291
S299
S307
T309
S312
S316
S318
S329
T341
T447
S449
S452
S454
S457
S475
T477
S491
S493
S1111
T1479
S1522
S1526
S1544
S1549
S1695
S1714
S1741
S1754
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.