RAPGEF2: Rap guanine nucleotide exchange factor 2
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
Y500 DIKKASRY SIPDLAV 1 8 - - 8 - - - - - - - - - - - - - - - - - S501 IKKASRYS IPDLAVD 7 749 - - 103 80 - - 63 - 91 53 59 54 106 96 - - 24 11 7 2 S558 NDIGIGQS QDDSIVG 3 27 - - - - - - 9 - - - - - 5 4 - - - - 7 2 S579 IPTALPVS GTLSSSN 1 9 - - - - - - - - 6 3 - - - - - - - - - - S583 LPVSGTLS SSNPDLL 3 44 - - - - - - 9 - 6 3 - - 14 12 - - - - - - S585 VSGTLSSS NPDLLQS 4 114 - - - - - - 80 - 6 3 - - 4 3 - - - - 7 11 T602 RILDFSAT PDLPDQV 4 166 - - 22 12 - - - - - - 34 31 30 28 - - - - - 9 S912 RHVGRMAS VNMDPAL 1 8 - - - - - - - - - - - - 4 4 - - - - - - S930 TRKKKWRS LGSLSQG 7 822 - - 54 42 - - 99 - 98 57 89 81 97 89 - - 52 22 29 13 S933 KKWRSLGS LSQGSTN 5 128 - - 4 4 - - 45 - - - 15 14 - - - - 13 6 25 2
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Y500 DIKKASRY SIPDLAV - - - - - - - - - - - S501 IKKASRYS IPDLAVD -2.8e-7 - 4.6e-26 - - -3.3e-16 -2.9e-15 -0.047 - -0.099 - S558 NDIGIGQS QDDSIVG - - - - - - - - - - - S579 IPTALPVS GTLSSSN - - - - - - - - - - - S583 LPVSGTLS SSNPDLL - - - - - - - - - - - S585 VSGTLSSS NPDLLQS - - - - - - - - - - - T602 RILDFSAT PDLPDQV -1.4e-11 - 0.96 - - - -9e-13 -4.0e-6 - - - S912 RHVGRMAS VNMDPAL - - - - - - - - - - - S930 TRKKKWRS LGSLSQG -4.3e-11 - 3.4e-15 - - -3.9e-6 -1.7e-16 -2.3e-18 - -0.87 -0.024 S933 KKWRSLGS LSQGSTN - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
Y500
S501
S558
S579
S583
S585
T602
S912
S930
S933
S935
S938
T939
S960
T1006
T1021
S1022
S1080
S1089
S1091
S1095
S1115
S1116
T1119
S1120
S1123
S1124
S1153
S1158
S1159
S1162
S1176
S1178
S1201
S1223
S1225
S1248
S1256
S1268
S1313
S1316
S1325
Y1332
S1337
T1402
Y1406
T1488
S1497
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA Y500 S501 S558 S579 S583 S585 T602 S912 S930 S933 S935 S938 T939 S960 T1006 T1021 S1022 S1080 S1089 S1091 S1095 S1115 S1116 T1119 S1120 S1123 S1124 S1153 S1158 S1159 S1162 S1176 S1178 S1201 S1223 S1225 S1248 S1256 S1268 S1313 S1316 S1325 Y1332 S1337 T1402 Y1406 T1488 S1497 protein RNA SCNV methylation CCRCC Y500 S501 S558 S579 S583 S585 T602 S912 S930 S933 S935 S938 T939 S960 T1006 T1021 S1022 S1080 S1089 S1091 S1095 S1115 S1116 T1119 S1120 S1123 S1124 S1153 S1158 S1159 S1162 S1176 S1178 S1201 S1223 S1225 S1248 S1256 S1268 S1313 S1316 S1325 Y1332 S1337 T1402 Y1406 T1488 S1497 protein RNA SCNV methylation COAD Y500 S501 S558 S579 S583 S585 T602 S912 S930 S933 S935 S938 T939 S960 T1006 T1021 S1022 S1080 S1089 S1091 S1095 S1115 S1116 T1119 S1120 S1123 S1124 S1153 S1158 S1159 S1162 S1176 S1178 S1201 S1223 S1225 S1248 S1256 S1268 S1313 S1316 S1325 Y1332 S1337 T1402 Y1406 T1488 S1497 protein RNA SCNV methylation GBM Y500 S501 S558 S579 S583 S585 T602 S912 S930 S933 S935 S938 T939 S960 T1006 T1021 S1022 S1080 S1089 S1091 S1095 S1115 S1116 T1119 S1120 S1123 S1124 S1153 S1158 S1159 S1162 S1176 S1178 S1201 S1223 S1225 S1248 S1256 S1268 S1313 S1316 S1325 Y1332 S1337 T1402 Y1406 T1488 S1497 protein RNA SCNV methylation HNSCC Y500 S501 S558 S579 S583 S585 T602 S912 S930 S933 S935 S938 T939 S960 T1006 T1021 S1022 S1080 S1089 S1091 S1095 S1115 S1116 T1119 S1120 S1123 S1124 S1153 S1158 S1159 S1162 S1176 S1178 S1201 S1223 S1225 S1248 S1256 S1268 S1313 S1316 S1325 Y1332 S1337 T1402 Y1406 T1488 S1497 protein RNA SCNV methylation LSCC Y500 S501 S558 S579 S583 S585 T602 S912 S930 S933 S935 S938 T939 S960 T1006 T1021 S1022 S1080 S1089 S1091 S1095 S1115 S1116 T1119 S1120 S1123 S1124 S1153 S1158 S1159 S1162 S1176 S1178 S1201 S1223 S1225 S1248 S1256 S1268 S1313 S1316 S1325 Y1332 S1337 T1402 Y1406 T1488 S1497 protein RNA SCNV methylation LUAD Y500 S501 S558 S579 S583 S585 T602 S912 S930 S933 S935 S938 T939 S960 T1006 T1021 S1022 S1080 S1089 S1091 S1095 S1115 S1116 T1119 S1120 S1123 S1124 S1153 S1158 S1159 S1162 S1176 S1178 S1201 S1223 S1225 S1248 S1256 S1268 S1313 S1316 S1325 Y1332 S1337 T1402 Y1406 T1488 S1497 protein RNA SCNV methylation OV Y500 S501 S558 S579 S583 S585 T602 S912 S930 S933 S935 S938 T939 S960 T1006 T1021 S1022 S1080 S1089 S1091 S1095 S1115 S1116 T1119 S1120 S1123 S1124 S1153 S1158 S1159 S1162 S1176 S1178 S1201 S1223 S1225 S1248 S1256 S1268 S1313 S1316 S1325 Y1332 S1337 T1402 Y1406 T1488 S1497 protein RNA SCNV methylation PDAC Y500 S501 S558 S579 S583 S585 T602 S912 S930 S933 S935 S938 T939 S960 T1006 T1021 S1022 S1080 S1089 S1091 S1095 S1115 S1116 T1119 S1120 S1123 S1124 S1153 S1158 S1159 S1162 S1176 S1178 S1201 S1223 S1225 S1248 S1256 S1268 S1313 S1316 S1325 Y1332 S1337 T1402 Y1406 T1488 S1497 protein RNA SCNV methylation UCEC Y500 S501 S558 S579 S583 S585 T602 S912 S930 S933 S935 S938 T939 S960 T1006 T1021 S1022 S1080 S1089 S1091 S1095 S1115 S1116 T1119 S1120 S1123 S1124 S1153 S1158 S1159 S1162 S1176 S1178 S1201 S1223 S1225 S1248 S1256 S1268 S1313 S1316 S1325 Y1332 S1337 T1402 Y1406 T1488 S1497 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
Y500
S501
S558
S579
S583
S585
T602
S912
S930
S933
S935
S938
T939
S960
T1006
T1021
S1022
S1080
S1089
S1091
S1095
S1115
S1116
T1119
S1120
S1123
S1124
S1153
S1158
S1159
S1162
S1176
S1178
S1201
S1223
S1225
S1248
S1256
S1268
S1313
S1316
S1325
Y1332
S1337
T1402
Y1406
T1488
S1497
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
Y500
S501
S558
S579
S583
S585
T602
S912
S930
S933
S935
S938
T939
S960
T1006
T1021
S1022
S1080
S1089
S1091
S1095
S1115
S1116
T1119
S1120
S1123
S1124
S1153
S1158
S1159
S1162
S1176
S1178
S1201
S1223
S1225
S1248
S1256
S1268
S1313
S1316
S1325
Y1332
S1337
T1402
Y1406
T1488
S1497
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.