Protein: ENSP00000264657
Gene: STAT3

LinkedOmicsKB © 2022-2023 Zhang Lab

STAT3:
signal transducer and activator of transcription 3

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
Y539LLGPGVNYSGCQITW18--44----------------
S540LGPGVNYSGCQITWA389--------5415142625------
S668DATNILVSPLVYLYP116--88----------------
S691GKYCRPESQEHPEAD617717-------199442825--185435
S701HPEADPGSAAPYLKT10103477-8370323199-92529487716327663254913
Y705DPGSAAPYLKTKFIC101478122-99769710099-10862108991101013811105448118
T714KTKFICVTPTTCSNT4131----152118-------345--299
T716KFICVTPTTCSNTID10105472-6755211546-10862103928272531088356211
T717FICVTPTTCSNTIDL1018722-211861218-26151094371735-
S719CVTPTTCSNTIDLPM88018-44126--634444--326-
Showing 1 to 10 of 14 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Y539LLGPGVNYSGCQITW-----------
S540LGPGVNYSGCQITWA-0.3-------0.3---
S668DATNILVSPLVYLYP-----------
S691GKYCRPESQEHPEAD6.2e-3------6.2e-3---
S701HPEADPGSAAPYLKT4.7e-5-0.37-0.77-0.28-0.828.7e-4-5.8e-31.2e-3
Y705DPGSAAPYLKTKFIC-1e-25--2.4e-3-7.1e-10--0.51-1.7e-31-1.3e-25-0.0131.2e-30.11
T714KTKFICVTPTTCSNT-----------
T716KFICVTPTTCSNTID-0.32--8.6e-3-0.096-0.052-0.918.4e-60.81-2e-80.55
T717FICVTPTTCSNTIDL0.5-0.9--0.41-----
S719CVTPTTCSNTIDLPM-----------
Showing 1 to 10 of 14 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAY539S540S668S691S701Y705T714T716T717S719T721S727S747S768proteinRNASCNVmethylationCCRCCY539S540S668S691S701Y705T714T716T717S719T721S727S747S768proteinRNASCNVmethylationCOADY539S540S668S691S701Y705T714T716T717S719T721S727S747S768proteinRNASCNVmethylationGBMY539S540S668S691S701Y705T714T716T717S719T721S727S747S768proteinRNASCNVmethylationHNSCCY539S540S668S691S701Y705T714T716T717S719T721S727S747S768proteinRNASCNVmethylationLSCCY539S540S668S691S701Y705T714T716T717S719T721S727S747S768proteinRNASCNVmethylationLUADY539S540S668S691S701Y705T714T716T717S719T721S727S747S768proteinRNASCNVmethylationOVY539S540S668S691S701Y705T714T716T717S719T721S727S747S768proteinRNASCNVmethylationPDACY539S540S668S691S701Y705T714T716T717S719T721S727S747S768proteinRNASCNVmethylationUCECY539S540S668S691S701Y705T714T716T717S719T721S727S747S768proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.