CAD: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
4by3 chain A
4c6b chain A
4c6c chain A
4c6d chain A
4c6e chain A
4c6f chain A
4c6i chain A
4c6j chain A
4c6k chain A
4c6l chain A
4c6m chain A
4c6n chain A
4c6o chain A
4c6p chain A
4c6q chain A
5g1n chain A
5g1n chain B
5g1n chain C
5g1n chain D
5g1n chain E
5g1n chain F
5g1o chain A
5g1o chain B
5g1o chain C
5g1o chain D
5g1o chain E
5g1o chain F
5g1p chain A
5g1p chain B
5g1p chain C
5g1p chain D
5g1p chain E
5g1p chain F
5ynz chain A
6hfd chain A
6hfe chain A
6hff chain A
6hfh chain A
6hfi chain A
6hfj chain A
6hfk chain A
6hfl chain A
6hfn chain A
6hfp chain A
6hfq chain A
6hfr chain A
6hfs chain A
6hfu chain A
6hg1 chain A
6hg2 chain A
6hg3 chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S133 KKLREQGS LLGKLVQ 1 7 - - - - - - - - - - - - 4 3 - - - - - - S147 QNGTEPSS LPFLDPN 1 8 - - - - - - - - - - - - 4 4 - - - - - - S1038 QCRVLGTS PEAIDSA 6 134 21 - 4 4 - - 19 - 6 3 10 9 - - - - - - 54 4 S1321 NILLTIGS YKNKSEL 2 18 - - - - - - - - - - 5 5 4 4 - - - - - - S1406 GAGGRRLS SFVTKGY 10 1188 64 - 54 33 92 96 99 - 96 54 83 76 54 49 76 17 105 42 80 18 S1407 AGGRRLSS FVTKGYR 9 264 9 - 41 30 - - 9 - 5 2 28 25 37 32 7 1 11 4 16 7 S1823 AVPQLPPS APATSEM 8 351 71 - 41 32 8 10 9 - 5 4 19 19 51 48 - - - - 30 4 T1827 LPPSAPAT SEMTTTP 2 47 - - - - - - - - - - - - 4 4 - - - - 26 13 S1828 PPSAPATS EMTTTPE 4 33 - - - - 1 7 - - 5 3 - - - - 7 1 6 3 - - T1831 APATSEMT TTPERPR 7 131 - - 4 4 21 15 - - 11 8 - - 5 4 8 1 20 9 19 2
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S133 KKLREQGS LLGKLVQ - - - - - - - - - - - S147 QNGTEPSS LPFLDPN - - - - - - - - - - - S1038 QCRVLGTS PEAIDSA - - - - - - - - - - - S1321 NILLTIGS YKNKSEL - - - - - - - - - - - S1406 GAGGRRLS SFVTKGY 7.3e-17 - 2.2e-12 -0.013 - 2.4e-18 1.2e-3 9.4e-3 0.076 1e-8 -2.6e-3 S1407 AGGRRLSS FVTKGYR 1.8e-18 - 0.83 - - - 1.5e-12 2.8e-15 - - - S1823 AVPQLPPS APATSEM 2.0e-4 - 3.2e-4 - - - - 0.098 - - - T1827 LPPSAPAT SEMTTTP -0.76 - - - - - - - - - -0.76 S1828 PPSAPATS EMTTTPE - - - - - - - - - - - T1831 APATSEMT TTPERPR 0.083 - - 0.083 - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S133
S147
S1038
S1321
S1406
S1407
S1823
T1827
S1828
T1831
T1832
T1833
S1859
T1884
S1900
S1920
S1938
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S133 S147 S1038 S1321 S1406 S1407 S1823 T1827 S1828 T1831 T1832 T1833 S1859 T1884 S1900 S1920 S1938 protein RNA SCNV methylation CCRCC S133 S147 S1038 S1321 S1406 S1407 S1823 T1827 S1828 T1831 T1832 T1833 S1859 T1884 S1900 S1920 S1938 protein RNA SCNV methylation COAD S133 S147 S1038 S1321 S1406 S1407 S1823 T1827 S1828 T1831 T1832 T1833 S1859 T1884 S1900 S1920 S1938 protein RNA SCNV methylation GBM S133 S147 S1038 S1321 S1406 S1407 S1823 T1827 S1828 T1831 T1832 T1833 S1859 T1884 S1900 S1920 S1938 protein RNA SCNV methylation HNSCC S133 S147 S1038 S1321 S1406 S1407 S1823 T1827 S1828 T1831 T1832 T1833 S1859 T1884 S1900 S1920 S1938 protein RNA SCNV methylation LSCC S133 S147 S1038 S1321 S1406 S1407 S1823 T1827 S1828 T1831 T1832 T1833 S1859 T1884 S1900 S1920 S1938 protein RNA SCNV methylation LUAD S133 S147 S1038 S1321 S1406 S1407 S1823 T1827 S1828 T1831 T1832 T1833 S1859 T1884 S1900 S1920 S1938 protein RNA SCNV methylation OV S133 S147 S1038 S1321 S1406 S1407 S1823 T1827 S1828 T1831 T1832 T1833 S1859 T1884 S1900 S1920 S1938 protein RNA SCNV methylation PDAC S133 S147 S1038 S1321 S1406 S1407 S1823 T1827 S1828 T1831 T1832 T1833 S1859 T1884 S1900 S1920 S1938 protein RNA SCNV methylation UCEC S133 S147 S1038 S1321 S1406 S1407 S1823 T1827 S1828 T1831 T1832 T1833 S1859 T1884 S1900 S1920 S1938 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S133
S147
S1038
S1321
S1406
S1407
S1823
T1827
S1828
T1831
T1832
T1833
S1859
T1884
S1900
S1920
S1938
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S133
S147
S1038
S1321
S1406
S1407
S1823
T1827
S1828
T1831
T1832
T1833
S1859
T1884
S1900
S1920
S1938
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.