WWC1: WW and C2 domain containing 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2z0u chain A
2z0u chain B
6fb4 chain A
6fb4 chain B
6fd0 chain A
6fd0 chain B
6fjc chain A
6fjc chain B
6fjd chain A
6fjd chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
Y128 LELAQQEY QQLHAVW 1 9 - - - - - - 9 - - - - - - - - - - - - - S141 VWEHKLGS QVSLVSG 6 354 - - 62 48 4 5 26 - - - 20 17 57 52 - - - - 54 9 S144 HKLGSQVS LVSGSSS 4 100 - - 37 36 - - - - - - 5 5 4 4 - - - - 7 2 S149 QVSLVSGS SSSSKYD 2 31 - - 8 5 - - - - - - - - 10 8 - - - - - - S150 VSLVSGSS SSSKYDP 1 6 - - - - - - - - - - - - - - - - - - 6 - S208 KMSDAQGS YKLDEAQ 8 426 - - 82 68 4 5 27 - - - 14 14 87 82 7 2 5 2 18 9 S255 GFRTDRGS HSDLWSS 5 96 - - - - - - 27 - 22 14 10 8 5 4 - - - - 6 - S257 RTDRGSHS DLWSSSS 1 28 - - - - - - - - 17 11 - - - - - - - - - - S264 SDLWSSSS SLESSSF 1 9 - - - - - - 9 - - - - - - - - - - - - - S265 DLWSSSSS LESSSFP 1 36 - - - - - - 36 - - - - - - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Y128 LELAQQEY QQLHAVW - - - - - - - - - - - S141 VWEHKLGS QVSLVSG 0.84 - 0.011 - - - -0.33 -0.23 - - - S144 HKLGSQVS LVSGSSS 0.006 - 0.006 - - - - - - - - S149 QVSLVSGS SSSSKYD - - - - - - - - - - - S150 VSLVSGSS SSSKYDP - - - - - - - - - - - S208 KMSDAQGS YKLDEAQ -0.75 - -1.8e-3 - - - - 7.7e-3 - - - S255 GFRTDRGS HSDLWSS -2.1e-5 - - - - -2.1e-5 - - - - - S257 RTDRGSHS DLWSSSS - - - - - - - - - - - S264 SDLWSSSS SLESSSF - - - - - - - - - - - S265 DLWSSSSS LESSSFP - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
Y128
S141
S144
S149
S150
S208
S255
S257
S264
S265
S435
S438
S523
S525
T527
S535
S651
S833
S834
S841
S848
S876
T895
S899
T912
S922
S927
T929
S931
S947
S949
S950
S962
S1081
S1109
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA Y128 S141 S144 S149 S150 S208 S255 S257 S264 S265 S435 S438 S523 S525 T527 S535 S651 S833 S834 S841 S848 S876 T895 S899 T912 S922 S927 T929 S931 S947 S949 S950 S962 S1081 S1109 protein RNA SCNV methylation CCRCC Y128 S141 S144 S149 S150 S208 S255 S257 S264 S265 S435 S438 S523 S525 T527 S535 S651 S833 S834 S841 S848 S876 T895 S899 T912 S922 S927 T929 S931 S947 S949 S950 S962 S1081 S1109 protein RNA SCNV methylation COAD Y128 S141 S144 S149 S150 S208 S255 S257 S264 S265 S435 S438 S523 S525 T527 S535 S651 S833 S834 S841 S848 S876 T895 S899 T912 S922 S927 T929 S931 S947 S949 S950 S962 S1081 S1109 protein RNA SCNV methylation GBM Y128 S141 S144 S149 S150 S208 S255 S257 S264 S265 S435 S438 S523 S525 T527 S535 S651 S833 S834 S841 S848 S876 T895 S899 T912 S922 S927 T929 S931 S947 S949 S950 S962 S1081 S1109 protein RNA SCNV methylation HNSCC Y128 S141 S144 S149 S150 S208 S255 S257 S264 S265 S435 S438 S523 S525 T527 S535 S651 S833 S834 S841 S848 S876 T895 S899 T912 S922 S927 T929 S931 S947 S949 S950 S962 S1081 S1109 protein RNA SCNV methylation LSCC Y128 S141 S144 S149 S150 S208 S255 S257 S264 S265 S435 S438 S523 S525 T527 S535 S651 S833 S834 S841 S848 S876 T895 S899 T912 S922 S927 T929 S931 S947 S949 S950 S962 S1081 S1109 protein RNA SCNV methylation LUAD Y128 S141 S144 S149 S150 S208 S255 S257 S264 S265 S435 S438 S523 S525 T527 S535 S651 S833 S834 S841 S848 S876 T895 S899 T912 S922 S927 T929 S931 S947 S949 S950 S962 S1081 S1109 protein RNA SCNV methylation OV Y128 S141 S144 S149 S150 S208 S255 S257 S264 S265 S435 S438 S523 S525 T527 S535 S651 S833 S834 S841 S848 S876 T895 S899 T912 S922 S927 T929 S931 S947 S949 S950 S962 S1081 S1109 protein RNA SCNV methylation PDAC Y128 S141 S144 S149 S150 S208 S255 S257 S264 S265 S435 S438 S523 S525 T527 S535 S651 S833 S834 S841 S848 S876 T895 S899 T912 S922 S927 T929 S931 S947 S949 S950 S962 S1081 S1109 protein RNA SCNV methylation UCEC Y128 S141 S144 S149 S150 S208 S255 S257 S264 S265 S435 S438 S523 S525 T527 S535 S651 S833 S834 S841 S848 S876 T895 S899 T912 S922 S927 T929 S931 S947 S949 S950 S962 S1081 S1109 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
Y128
S141
S144
S149
S150
S208
S255
S257
S264
S265
S435
S438
S523
S525
T527
S535
S651
S833
S834
S841
S848
S876
T895
S899
T912
S922
S927
T929
S931
S947
S949
S950
S962
S1081
S1109
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
Y128
S141
S144
S149
S150
S208
S255
S257
S264
S265
S435
S438
S523
S525
T527
S535
S651
S833
S834
S841
S848
S876
T895
S899
T912
S922
S927
T929
S931
S947
S949
S950
S962
S1081
S1109
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.