PTPN23: protein tyrosine phosphatase non-receptor type 23
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
3rau chain A
3rau chain B
5cru chain A
5cru chain B
5cru chain C
5cru chain D
5crv chain A
5crv chain B
5lm1 chain A
5lm2 chain A
5lm2 chain B
5mjy chain A
5mjy chain B
5mjy chain C
5mjy chain D
5mjz chain A
5mjz chain B
5mk0 chain A
5mk0 chain C
5mk1 chain A
5mk1 chain B
5mk1 chain C
5mk1 chain D
5mk2 chain A
5mk2 chain B
5mk3 chain A
5mk3 chain B
5mk3 chain C
5mk3 chain D
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
Y34 KKFVLKNY GENPEAY 1 9 - - - - 7 2 - - - - - - - - - - - - - - S228 LENPDTAS LLGRIQK 2 60 - - 24 23 - - - - - - - - - - - - - - 13 - S369 PMAAHEAS SLYSEEK 1 8 - - 4 4 - - - - - - - - - - - - - - - - S370 MAAHEASS LYSEEKA 3 51 15 - 15 14 - - - - - - - - - - - - - - 7 - S455 VFTDVEAS LKDIRDL 1 10 - - - - - - - - 6 4 - - - - - - - - - - S484 VGQAGAIS ITSKAEL 8 707 104 - 13 12 - - 19 - 81 44 88 80 89 79 - - 39 16 41 2 S589 QKDDITAS LVTTDHS 6 176 32 - 7 7 - - - - - - 30 27 30 29 8 1 4 1 - - T592 DITASLVT TDHSEMK 1 8 - - - - - - - - - - 4 4 - - - - - - - - S733 LLPRREES EAVEAGD 6 279 41 - 4 3 - - 36 - - - 59 55 27 24 - - - - 21 9 S747 DPPEELRS LPPDMVA 10 1131 105 - 95 80 12 15 72 - 92 51 88 79 102 92 13 3 105 44 67 16
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Y34 KKFVLKNY GENPEAY - - - - - - - - - - - S228 LENPDTAS LLGRIQK -1.8e-4 - -1.8e-4 - - - - - - - - S369 PMAAHEAS SLYSEEK - - - - - - - - - - - S370 MAAHEASS LYSEEKA - - - - - - - - - - - S455 VFTDVEAS LKDIRDL - - - - - - - - - - - S484 VGQAGAIS ITSKAEL -1.1e-7 - - - - -0.3 -1.4e-7 -1.1e-3 - -0.31 - S589 QKDDITAS LVTTDHS 0.023 - - - - - 0.2 0.053 - - - T592 DITASLVT TDHSEMK - - - - - - - - - - - S733 LLPRREES EAVEAGD 0.5 - - - - - -0.047 3.2e-3 - - - S747 DPPEELRS LPPDMVA -4.9e-6 - -5.7e-13 - - 0.94 0.9 2.2e-4 - -2.2e-11 -0.24
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
Y34
S228
S369
S370
S455
S484
S589
T592
S733
S747
S1121
S1122
S1123
S1126
T1131
S1133
T1193
S1335
S1473
S1484
S1496
S1497
S1593
S1620
S1625
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA Y34 S228 S369 S370 S455 S484 S589 T592 S733 S747 S1121 S1122 S1123 S1126 T1131 S1133 T1193 S1335 S1473 S1484 S1496 S1497 S1593 S1620 S1625 protein RNA SCNV methylation CCRCC Y34 S228 S369 S370 S455 S484 S589 T592 S733 S747 S1121 S1122 S1123 S1126 T1131 S1133 T1193 S1335 S1473 S1484 S1496 S1497 S1593 S1620 S1625 protein RNA SCNV methylation COAD Y34 S228 S369 S370 S455 S484 S589 T592 S733 S747 S1121 S1122 S1123 S1126 T1131 S1133 T1193 S1335 S1473 S1484 S1496 S1497 S1593 S1620 S1625 protein RNA SCNV methylation GBM Y34 S228 S369 S370 S455 S484 S589 T592 S733 S747 S1121 S1122 S1123 S1126 T1131 S1133 T1193 S1335 S1473 S1484 S1496 S1497 S1593 S1620 S1625 protein RNA SCNV methylation HNSCC Y34 S228 S369 S370 S455 S484 S589 T592 S733 S747 S1121 S1122 S1123 S1126 T1131 S1133 T1193 S1335 S1473 S1484 S1496 S1497 S1593 S1620 S1625 protein RNA SCNV methylation LSCC Y34 S228 S369 S370 S455 S484 S589 T592 S733 S747 S1121 S1122 S1123 S1126 T1131 S1133 T1193 S1335 S1473 S1484 S1496 S1497 S1593 S1620 S1625 protein RNA SCNV methylation LUAD Y34 S228 S369 S370 S455 S484 S589 T592 S733 S747 S1121 S1122 S1123 S1126 T1131 S1133 T1193 S1335 S1473 S1484 S1496 S1497 S1593 S1620 S1625 protein RNA SCNV methylation OV Y34 S228 S369 S370 S455 S484 S589 T592 S733 S747 S1121 S1122 S1123 S1126 T1131 S1133 T1193 S1335 S1473 S1484 S1496 S1497 S1593 S1620 S1625 protein RNA SCNV methylation PDAC Y34 S228 S369 S370 S455 S484 S589 T592 S733 S747 S1121 S1122 S1123 S1126 T1131 S1133 T1193 S1335 S1473 S1484 S1496 S1497 S1593 S1620 S1625 protein RNA SCNV methylation UCEC Y34 S228 S369 S370 S455 S484 S589 T592 S733 S747 S1121 S1122 S1123 S1126 T1131 S1133 T1193 S1335 S1473 S1484 S1496 S1497 S1593 S1620 S1625 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
Y34
S228
S369
S370
S455
S484
S589
T592
S733
S747
S1121
S1122
S1123
S1126
T1131
S1133
T1193
S1335
S1473
S1484
S1496
S1497
S1593
S1620
S1625
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
Y34
S228
S369
S370
S455
S484
S589
T592
S733
S747
S1121
S1122
S1123
S1126
T1131
S1133
T1193
S1335
S1473
S1484
S1496
S1497
S1593
S1620
S1625
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.