Protein: ENSP00000265807
Gene: SH2D4A

LinkedOmicsKB © 2022-2023 Zhang Lab

SH2D4A:
SH2 domain containing 4A

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S51AAMERKESLPVKPRP94108-20125435-734224223227--69298-
S118EEPRKTHSEEFTNSL460--44------1010----167-9
S124HSEEFTNSLKTKSQY91112104-9472--8-9557989010192429101428918
S172LEEEKIRSLSSSSRN15----------------41--
S187IQQMLADSINRMKAY19------------54------
S235EDSEWQASLRKSKAA983328-7756--9-6337103941069827648184716
S261REDYKRLSLGAQKGR101323104-7064525599-97561089910193681794418916
S315QGVVRTLSSSAQEDI1093136-44838790-583374673227681796429518
S316GVVRTLSSSAQEDII668----63----555414310472
S363KANELLLSTGMPGSF35615-----------171572----
Showing 1 to 10 of 13 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S51AAMERKESLPVKPRP-0.084-0.044---0.19-2.1e-30.026--1.9e-4-
S118EEPRKTHSEEFTNSL-----------
S124HSEEFTNSLKTKSQY-0.11-1.6e-5---4.8e-8-1.3e-101.2e-3--0.0012.1e-4
S172LEEEKIRSLSSSSRN-----------
S187IQQMLADSINRMKAY-----------
S235EDSEWQASLRKSKAA-2.3e-7--0.018---5.8e-4-4.4e-25-0.13-3.1e-30.043
S261REDYKRLSLGAQKGR-5.6e-10-0.85-5.7e-5--2.3e-15-4.5e-29-0.490.16.3e-30.084
S315QGVVRTLSSSAQEDI-7.6e-6---0.41--1.2e-7-3e-150.12-0.640.790.41
S316GVVRTLSSSAQEDII-----------
S363KANELLLSTGMPGSF-----------
Showing 1 to 10 of 13 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS51S118S124S172S187S235S261S315S316S363T364S369S375proteinRNASCNVmethylationCCRCCS51S118S124S172S187S235S261S315S316S363T364S369S375proteinRNASCNVmethylationCOADS51S118S124S172S187S235S261S315S316S363T364S369S375proteinRNASCNVmethylationGBMS51S118S124S172S187S235S261S315S316S363T364S369S375proteinRNASCNVmethylationHNSCCS51S118S124S172S187S235S261S315S316S363T364S369S375proteinRNASCNVmethylationLSCCS51S118S124S172S187S235S261S315S316S363T364S369S375proteinRNASCNVmethylationLUADS51S118S124S172S187S235S261S315S316S363T364S369S375proteinRNASCNVmethylationOVS51S118S124S172S187S235S261S315S316S363T364S369S375proteinRNASCNVmethylationPDACS51S118S124S172S187S235S261S315S316S363T364S369S375proteinRNASCNVmethylationUCECS51S118S124S172S187S235S261S315S316S363T364S369S375proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.