HPS5: HPS5 biogenesis of lysosomal organelles complex 2 subunit 2
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S429 LKFEPLDS ACSSRRS 3 32 7 - - - - - - - - - - - - - 14 3 - - 6 2 S432 EPLDSACS SRRSSIS 8 168 9 - 17 16 11 7 - - - - 10 9 20 16 14 2 16 6 10 5 S433 PLDSACSS RRSSISS 9 286 - - 5 4 3 6 54 - 16 10 24 22 4 4 13 4 53 24 35 5 S436 SACSSRRS SISSHES 2 26 8 - - - - - 18 - - - - - - - - - - - - - S437 ACSSRRSS ISSHESF 3 43 8 - - - - - 18 - - - - - - - 13 4 - - - - S439 SSRRSSIS SHESFSI 1 7 7 - - - - - - - - - - - - - - - - - - - S440 SRRSSISS HESFSIL 3 33 7 - - - - - 18 - 5 3 - - - - - - - - - - S461 IISSRRGS QSDEDSC 8 167 22 - - - 5 4 45 - 19 10 4 4 9 7 7 1 - - 24 6 S463 SSRRGSQS DEDSCSL 7 145 22 - - - 5 4 9 - 26 13 10 10 9 7 - - - - 24 6 S467 GSQSDEDS CSLHSQT 6 86 7 - - - - - 18 - 12 7 5 4 10 8 - - - - 13 2
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S429 LKFEPLDS ACSSRRS - - - - - - - - - - - S432 EPLDSACS SRRSSIS -3.1e-3 - - - - - - -3.1e-3 - - - S433 PLDSACSS RRSSISS -0.071 - - - - - -0.59 - - -0.044 - S436 SACSSRRS SISSHES - - - - - - - - - - - S437 ACSSRRSS ISSHESF - - - - - - - - - - - S439 SSRRSSIS SHESFSI - - - - - - - - - - - S440 SRRSSISS HESFSIL - - - - - - - - - - - S461 IISSRRGS QSDEDSC - - - - - - - - - - - S463 SSRRGSQS DEDSCSL 0.016 - - - - 0.016 - - - - - S467 GSQSDEDS CSLHSQT - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S429
S432
S433
S436
S437
S439
S440
S461
S463
S467
S469
S534
T562
S563
S578
S584
S585
T587
T594
S602
T662
S665
S666
S695
S712
S716
S1054
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S429 S432 S433 S436 S437 S439 S440 S461 S463 S467 S469 S534 T562 S563 S578 S584 S585 T587 T594 S602 T662 S665 S666 S695 S712 S716 S1054 protein RNA SCNV methylation CCRCC S429 S432 S433 S436 S437 S439 S440 S461 S463 S467 S469 S534 T562 S563 S578 S584 S585 T587 T594 S602 T662 S665 S666 S695 S712 S716 S1054 protein RNA SCNV methylation COAD S429 S432 S433 S436 S437 S439 S440 S461 S463 S467 S469 S534 T562 S563 S578 S584 S585 T587 T594 S602 T662 S665 S666 S695 S712 S716 S1054 protein RNA SCNV methylation GBM S429 S432 S433 S436 S437 S439 S440 S461 S463 S467 S469 S534 T562 S563 S578 S584 S585 T587 T594 S602 T662 S665 S666 S695 S712 S716 S1054 protein RNA SCNV methylation HNSCC S429 S432 S433 S436 S437 S439 S440 S461 S463 S467 S469 S534 T562 S563 S578 S584 S585 T587 T594 S602 T662 S665 S666 S695 S712 S716 S1054 protein RNA SCNV methylation LSCC S429 S432 S433 S436 S437 S439 S440 S461 S463 S467 S469 S534 T562 S563 S578 S584 S585 T587 T594 S602 T662 S665 S666 S695 S712 S716 S1054 protein RNA SCNV methylation LUAD S429 S432 S433 S436 S437 S439 S440 S461 S463 S467 S469 S534 T562 S563 S578 S584 S585 T587 T594 S602 T662 S665 S666 S695 S712 S716 S1054 protein RNA SCNV methylation OV S429 S432 S433 S436 S437 S439 S440 S461 S463 S467 S469 S534 T562 S563 S578 S584 S585 T587 T594 S602 T662 S665 S666 S695 S712 S716 S1054 protein RNA SCNV methylation PDAC S429 S432 S433 S436 S437 S439 S440 S461 S463 S467 S469 S534 T562 S563 S578 S584 S585 T587 T594 S602 T662 S665 S666 S695 S712 S716 S1054 protein RNA SCNV methylation UCEC S429 S432 S433 S436 S437 S439 S440 S461 S463 S467 S469 S534 T562 S563 S578 S584 S585 T587 T594 S602 T662 S665 S666 S695 S712 S716 S1054 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S429
S432
S433
S436
S437
S439
S440
S461
S463
S467
S469
S534
T562
S563
S578
S584
S585
T587
T594
S602
T662
S665
S666
S695
S712
S716
S1054
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S429
S432
S433
S436
S437
S439
S440
S461
S463
S467
S469
S534
T562
S563
S578
S584
S585
T587
T594
S602
T662
S665
S666
S695
S712
S716
S1054
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.