PIK3C2A: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2ar5 chain A
2iwl chain X
2rea chain A
2red chain A
6bty chain A
6bty chain B
6btz chain A
6btz chain B
6btz chain C
6btz chain D
6bu0 chain A
6bu0 chain B
6bu0 chain C
6bub chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
Loading, please wait
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S59 QRGFELSS STRKKAQ 1 8 - - 4 4 - - - - - - - - - - - - - - - - S60 RGFELSSS TRKKAQV 10 1168 105 - 103 80 16 11 90 - 77 45 103 95 106 97 6 2 105 44 68 15 S83 MVFPESDS QKRALDI 1 23 - - - - - - - - - - - - - - - - - - 20 3 S108 EKLLLDDS FETKKTP 9 383 38 - 25 16 - - 64 - 17 8 14 14 71 66 12 4 10 3 17 4 S124 LPVTPILS PSFSAQL 2 40 - - 7 7 - - - - - - - - 13 13 - - - - - - S259 KVSNLQVS PKSEDIS 10 1536 122 - 95 80 97 100 99 - 108 62 108 99 105 97 83 19 105 44 95 18 S297 EEEKNVSS LLAKDPW 8 520 7 - 57 52 - - 18 - - - 53 48 70 66 8 1 22 10 90 18 S329 KVNGKSLS VATVTRS 4 69 - - - - 6 3 - - - - 5 5 - - 22 4 - - 13 11 S338 ATVTRSQS LNIRTTQ 8 453 - - 17 15 51 65 46 - 32 22 - - 4 4 47 12 65 27 46 - S354 AKAQGHIS QKDPNGT 1 7 - - - - - - - - - - - - - - - - 5 2 - -
Tumor and normal comparison
Loading, please wait
Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S59 QRGFELSS STRKKAQ - - - - - - - - - - - S60 RGFELSSS TRKKAQV -1.6e-12 - -0.81 - - 3.3e-3 -5.5e-25 -2.3e-13 - -0.013 0.89 S83 MVFPESDS QKRALDI - - - - - - - - - - - S108 EKLLLDDS FETKKTP -0.011 - 5.5e-4 - - - - -1.5e-12 - - - S124 LPVTPILS PSFSAQL - - - - - - - - - - - S259 KVSNLQVS PKSEDIS -1.8e-3 - -5.4e-4 1.9e-16 - 0.29 -9.2e-12 -7.3e-5 -3.2e-5 -0.79 0.55 S297 EEEKNVSS LLAKDPW 4.7e-4 - -2.1e-3 - - - 0.16 0.013 - 0.018 3.8e-6 S329 KVNGKSLS VATVTRS - - - - - - - - - - - S338 ATVTRSQS LNIRTTQ 9.1e-8 - - 0.055 - 9.3e-4 - - -0.8 1.1e-8 - S354 AKAQGHIS QKDPNGT - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
Loading, please wait
all sites
S59
S60
S83
S108
S124
S259
S297
S329
S338
S354
S363
S369
S409
T614
S619
T626
S629
S630
S1084
S1281
S1399
S1403
S1546
S1551
S1553
T1555
Y1595
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S59 S60 S83 S108 S124 S259 S297 S329 S338 S354 S363 S369 S409 T614 S619 T626 S629 S630 S1084 S1281 S1399 S1403 S1546 S1551 S1553 T1555 Y1595 protein RNA SCNV methylation CCRCC S59 S60 S83 S108 S124 S259 S297 S329 S338 S354 S363 S369 S409 T614 S619 T626 S629 S630 S1084 S1281 S1399 S1403 S1546 S1551 S1553 T1555 Y1595 protein RNA SCNV methylation COAD S59 S60 S83 S108 S124 S259 S297 S329 S338 S354 S363 S369 S409 T614 S619 T626 S629 S630 S1084 S1281 S1399 S1403 S1546 S1551 S1553 T1555 Y1595 protein RNA SCNV methylation GBM S59 S60 S83 S108 S124 S259 S297 S329 S338 S354 S363 S369 S409 T614 S619 T626 S629 S630 S1084 S1281 S1399 S1403 S1546 S1551 S1553 T1555 Y1595 protein RNA SCNV methylation HNSCC S59 S60 S83 S108 S124 S259 S297 S329 S338 S354 S363 S369 S409 T614 S619 T626 S629 S630 S1084 S1281 S1399 S1403 S1546 S1551 S1553 T1555 Y1595 protein RNA SCNV methylation LSCC S59 S60 S83 S108 S124 S259 S297 S329 S338 S354 S363 S369 S409 T614 S619 T626 S629 S630 S1084 S1281 S1399 S1403 S1546 S1551 S1553 T1555 Y1595 protein RNA SCNV methylation LUAD S59 S60 S83 S108 S124 S259 S297 S329 S338 S354 S363 S369 S409 T614 S619 T626 S629 S630 S1084 S1281 S1399 S1403 S1546 S1551 S1553 T1555 Y1595 protein RNA SCNV methylation OV S59 S60 S83 S108 S124 S259 S297 S329 S338 S354 S363 S369 S409 T614 S619 T626 S629 S630 S1084 S1281 S1399 S1403 S1546 S1551 S1553 T1555 Y1595 protein RNA SCNV methylation PDAC S59 S60 S83 S108 S124 S259 S297 S329 S338 S354 S363 S369 S409 T614 S619 T626 S629 S630 S1084 S1281 S1399 S1403 S1546 S1551 S1553 T1555 Y1595 protein RNA SCNV methylation UCEC S59 S60 S83 S108 S124 S259 S297 S329 S338 S354 S363 S369 S409 T614 S619 T626 S629 S630 S1084 S1281 S1399 S1403 S1546 S1551 S1553 T1555 Y1595 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S59
S60
S83
S108
S124
S259
S297
S329
S338
S354
S363
S369
S409
T614
S619
T626
S629
S630
S1084
S1281
S1399
S1403
S1546
S1551
S1553
T1555
Y1595
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S59
S60
S83
S108
S124
S259
S297
S329
S338
S354
S363
S369
S409
T614
S619
T626
S629
S630
S1084
S1281
S1399
S1403
S1546
S1551
S1553
T1555
Y1595
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.