Protein: ENSP00000267101
Gene: ERBB3

LinkedOmicsKB © 2022-2023 Zhang Lab

ERBB3:
erb-b2 receptor tyrosine kinase 3

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S686RYLERGESIEPLDPS101525122-103809710099-1086210899106976715105449518
S717RKLKVLGSGVFGTVH632117-3735------35325851--623513
S846NVLLKSPSQVQVADF847723-32324329--11763566157--247239
S982YLVIKRESGPGIAPG101261122-9168818071-102591089911010120579341813
S1044TLNRPRGSQSLLSPS6114--121213149-----98--41239
S1083ERCPRPVSLHPMPRG19----------------54--
S1097GCLASESSEGHVTGS19--------------81----
S1104SEGHVTGSEAELQEK126--------------215----
S1130SPRPRGDSAYHSQRH395------9-64----679----
S1134RGDSAYHSQRHSLLT222--------------15232--
Showing 1 to 10 of 15 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S686RYLERGESIEPLDPS-0.019-1.3e-170.96--3.8e-8-2.1e-142.6e-4-0.22-4.8e-3-0.17
S717RKLKVLGSGVFGTVH0.19--0.002---3.7e-30.25--0.095
S846NVLLKSPSQVQVADF0.011--6.5e-90.14--5.0e-61.2e-6---
S982YLVIKRESGPGIAPG-5.8e-35-2.6e-5-7e-14--1.3e-13-1.3e-25-3.2e-7--7.7e-5-
S1044TLNRPRGSQSLLSPS-----------
S1083ERCPRPVSLHPMPRG-----------
S1097GCLASESSEGHVTGS-----------
S1104SEGHVTGSEAELQEK-----------
S1130SPRPRGDSAYHSQRH-----------
S1134RGDSAYHSQRHSLLT-----------
Showing 1 to 10 of 15 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS686S717S846S982S1044S1083S1097S1104S1130S1134S1138S1147Y1307S1315Y1328proteinRNASCNVmethylationCCRCCS686S717S846S982S1044S1083S1097S1104S1130S1134S1138S1147Y1307S1315Y1328proteinRNASCNVmethylationCOADS686S717S846S982S1044S1083S1097S1104S1130S1134S1138S1147Y1307S1315Y1328proteinRNASCNVmethylationGBMS686S717S846S982S1044S1083S1097S1104S1130S1134S1138S1147Y1307S1315Y1328proteinRNASCNVmethylationHNSCCS686S717S846S982S1044S1083S1097S1104S1130S1134S1138S1147Y1307S1315Y1328proteinRNASCNVmethylationLSCCS686S717S846S982S1044S1083S1097S1104S1130S1134S1138S1147Y1307S1315Y1328proteinRNASCNVmethylationLUADS686S717S846S982S1044S1083S1097S1104S1130S1134S1138S1147Y1307S1315Y1328proteinRNASCNVmethylationOVS686S717S846S982S1044S1083S1097S1104S1130S1134S1138S1147Y1307S1315Y1328proteinRNASCNVmethylationPDACS686S717S846S982S1044S1083S1097S1104S1130S1134S1138S1147Y1307S1315Y1328proteinRNASCNVmethylationUCECS686S717S846S982S1044S1083S1097S1104S1130S1134S1138S1147Y1307S1315Y1328proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.