FURIN: furin, paired basic amino acid cleaving enzyme
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
4omc chain A
4omc chain B
4omc chain C
4omc chain D
4omc chain E
4omc chain F
4omd chain A
4omd chain B
4omd chain C
4omd chain D
4omd chain E
4omd chain F
4ryd chain A
4ryd chain B
4ryd chain C
4ryd chain D
4ryd chain E
4ryd chain F
4z2a chain A
5jmo chain A
5jmo chain B
5jxg chain A
5jxh chain A
5jxi chain A
5jxj chain A
5mim chain A
6a8y chain A
6eqv chain A
6eqw chain A
6eqx chain A
6hlb chain A
6hld chain A
6hle chain A
6hza chain A
6hzb chain A
6hzc chain A
6hzd chain A
6yd2 chain A
6yd3 chain A
6yd4 chain A
6yd7 chain A
7lcu chain A
7o1u chain A
7o1w chain A
7o1y chain A
7o20 chain A
7o22 chain A
7qxy chain A
7qxz chain A
7qy0 chain A
7qy1 chain A
7qy2 chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S773 AWQEECPS DSEEDEG 7 469 65 - 90 68 - - - - 7 3 5 5 18 16 - - 84 35 55 18 S775 QEECPSDS EEDEGRG 7 959 65 - 90 68 - - - - 97 56 103 94 102 92 - - 84 35 55 18
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S773 AWQEECPS DSEEDEG -0.033 - -0.97 - - - - - - -1.6e-9 0.017 S775 QEECPSDS EEDEGRG -0.39 - -0.97 - - 0.026 0.055 0.1 - -1.6e-9 0.017
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S773
S775
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S773 S775 protein RNA SCNV methylation CCRCC S773 S775 protein RNA SCNV methylation COAD S773 S775 protein RNA SCNV methylation GBM S773 S775 protein RNA SCNV methylation HNSCC S773 S775 protein RNA SCNV methylation LSCC S773 S775 protein RNA SCNV methylation LUAD S773 S775 protein RNA SCNV methylation OV S773 S775 protein RNA SCNV methylation PDAC S773 S775 protein RNA SCNV methylation UCEC S773 S775 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S773
S775
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S773
S775
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.