Protein: ENSP00000268483
Gene: TXNL4B

LinkedOmicsKB © 2022-2023 Zhang Lab

TXNL4B:
thioredoxin like 4B

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S132RGKLIVQSPIDPKNI63186-3122--36-39232927------8718
Showing 1 to 1 of 1 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S132RGKLIVQSPIDPKNI2.0e-4-0.002---0.540.031---0.005
Showing 1 to 1 of 1 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
PERT-PSP_EGFS1322.7e-10-3.0e-4-4.0e-45.9e-30.091---0.012
KINASE-PSP_ERK2/MAPK1S1323.1e-9-0.01-1.7e-31.4e-30.1---6.5e-3
PERT-PSP_NOCODAZOLES1326.5e-7-1.1e-3-0.680.0110.16---5.1e-4
KINASE-PSP_ERK1/MAPK3S1329.4e-7-0.013-0.036.2e-40.12---0.18
HALLMARK_GLYCOLYSISS1328.5e-6-6.2e-3-0.180.870.061---1.2e-4
HALLMARK_ESTROGEN_RESPONSE_LATES1324.3e-5-0.084-0.0590.350.015---0.029
KINASE-PSP_CDK1S1324.9e-5-0.2-0.449.9e-30.029---0.024
HALLMARK_XENOBIOTIC_METABOLISMS1325.7e-5-0.038-0.0290.580.25---2.4e-3
KINASE-PSP_CDK2S1326.3e-5-1.4e-3--0.70.030.022---0.095
HALLMARK_ESTROGEN_RESPONSE_EARLYS1329.1e-5-0.061-0.0630.920.042---0.004
Showing 1 to 10 of 258 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS132proteinRNASCNVmethylationCCRCCS132proteinRNASCNVmethylationCOADS132proteinRNASCNVmethylationGBMS132proteinRNASCNVmethylationHNSCCS132proteinRNASCNVmethylationLSCCS132proteinRNASCNVmethylationLUADS132proteinRNASCNVmethylationOVS132proteinRNASCNVmethylationPDACS132proteinRNASCNVmethylationUCECS132proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
CERT1S1321.9e-5-3.4e-3-0.360.320.12---1.4e-3
PRKAA1S1325.4e-5-0.54-0.0030.170.11---0.013
CSNK1A1S1326.7e-5--0.45-0.0556.5e-55.1e-3---0.34
MAPK13S1329.8e-5-0.56-0.281.7e-30.33---3.2e-3
RPS6KB2S1321.1e-4-0.052-4.8e-30.008-0.89---0.18
RIOK3S1321.2e-4-0.014-0.42.1e-30.54---0.11
DAPK2S1324.6e-4-0.75-0.0150.90.5---2.0e-5
EGFRS1326.2e-4-4.7e-3--0.660.121.7e-3---0.57
MAP3K6S1326.6e-4-0.19-0.350.320.038---0.022
METS1326.7e-4-0.19-0.008-0.770.46---1.4e-3
Showing 1 to 10 of 538 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
PPP5CS132-7.9e-5--0.43--0.046-8.6e-3-0.042----0.17
INPP4AS132-5.7e-4--0.091-0.57-5.7e-3-0.71----5.7e-4
CTDSPL2S132-9.7e-4--0.084--0.13-0.6-0.35----7.6e-3
INPPL1S132-0.004--7.7e-3-0.16-4.6e-3-0.052----0.68
PLPPR4S132-0.004----0.004------
RNGTTS132-9.9e-3--0.82--0.097-0.42-0.039----0.32
PPM1BS132-0.012--0.027--0.33-0.024-0.58---0.72
PIP4P2S132-0.015-0.83--0.17-7.2e-3-0.74----0.2
PPP1CCS132-0.023-0.11--0.033-0.5-0.032----0.085
PTPN5S132-0.026----0.026------
Showing 1 to 10 of 240 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.