SSH2: slingshot protein phosphatase 2
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2nt2 chain A
2nt2 chain B
2nt2 chain C
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S9 ALVTVQRS PTPSTTS 2 18 - - - - 4 5 - - - - - - - - - - - - 7 2 S17 PTPSTTSS PCASEAD 3 79 - - - - 20 16 - - - - 10 10 - - - - - - 19 4 S21 TTSSPCAS EADSGEE 4 121 18 - 4 4 - - - - - - 19 19 29 28 - - - - - - S25 PCASEADS GEEECRS 5 153 - - - - 32 22 36 - - - 10 9 - - - - 4 1 34 5 S36 ECRSQPRS ISESFLT 6 108 7 - - - - - - - 5 4 14 14 13 12 - - 5 2 30 2 S38 RSQPRSIS ESFLTVK 2 18 - - - - - - 9 - - - - - 5 4 - - - - - - S40 QPRSISES FLTVKGA 2 18 - - - - - - 9 - - - - - 5 4 - - - - - - S461 NKLWRSHS DSDLSDH 9 349 21 - 13 12 36 27 87 - 33 21 9 8 28 24 - - 16 5 7 2 S463 LWRSHSDS DLSDHHE 3 64 9 - 13 12 - - - - - - 15 15 - - - - - - - - S466 SHSDSDLS DHHEPIC 7 151 9 - 4 4 - - 36 - 10 7 15 12 9 8 - - 26 11 - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S9 ALVTVQRS PTPSTTS - - - - - - - - - - - S17 PTPSTTSS PCASEAD -9.1e-3 - - -9.1e-3 - - - - - - - S21 TTSSPCAS EADSGEE 0.24 - - - - - - 0.24 - - - S25 PCASEADS GEEECRS -1 - - -1 - - - - - - - S36 ECRSQPRS ISESFLT - - - - - - - - - - - S38 RSQPRSIS ESFLTVK - - - - - - - - - - - S40 QPRSISES FLTVKGA - - - - - - - - - - - S461 NKLWRSHS DSDLSDH 1.2e-8 - - 1.0e-4 - 2.1e-4 - 0.024 - - - S463 LWRSHSDS DLSDHHE - - - - - - - - - - - S466 SHSDSDLS DHHEPIC -0.016 - - - - - - - - -0.016 -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S9
S17
S21
S25
S36
S38
S40
S461
S463
S466
T486
S487
S626
S670
S690
S710
T712
S734
T779
S784
T795
T870
S899
S1020
S1083
T1090
S1099
S1183
S1217
S1227
S1259
S1280
S1283
S1297
Y1420
T1422
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S9 S17 S21 S25 S36 S38 S40 S461 S463 S466 T486 S487 S626 S670 S690 S710 T712 S734 T779 S784 T795 T870 S899 S1020 S1083 T1090 S1099 S1183 S1217 S1227 S1259 S1280 S1283 S1297 Y1420 T1422 protein RNA SCNV methylation CCRCC S9 S17 S21 S25 S36 S38 S40 S461 S463 S466 T486 S487 S626 S670 S690 S710 T712 S734 T779 S784 T795 T870 S899 S1020 S1083 T1090 S1099 S1183 S1217 S1227 S1259 S1280 S1283 S1297 Y1420 T1422 protein RNA SCNV methylation COAD S9 S17 S21 S25 S36 S38 S40 S461 S463 S466 T486 S487 S626 S670 S690 S710 T712 S734 T779 S784 T795 T870 S899 S1020 S1083 T1090 S1099 S1183 S1217 S1227 S1259 S1280 S1283 S1297 Y1420 T1422 protein RNA SCNV methylation GBM S9 S17 S21 S25 S36 S38 S40 S461 S463 S466 T486 S487 S626 S670 S690 S710 T712 S734 T779 S784 T795 T870 S899 S1020 S1083 T1090 S1099 S1183 S1217 S1227 S1259 S1280 S1283 S1297 Y1420 T1422 protein RNA SCNV methylation HNSCC S9 S17 S21 S25 S36 S38 S40 S461 S463 S466 T486 S487 S626 S670 S690 S710 T712 S734 T779 S784 T795 T870 S899 S1020 S1083 T1090 S1099 S1183 S1217 S1227 S1259 S1280 S1283 S1297 Y1420 T1422 protein RNA SCNV methylation LSCC S9 S17 S21 S25 S36 S38 S40 S461 S463 S466 T486 S487 S626 S670 S690 S710 T712 S734 T779 S784 T795 T870 S899 S1020 S1083 T1090 S1099 S1183 S1217 S1227 S1259 S1280 S1283 S1297 Y1420 T1422 protein RNA SCNV methylation LUAD S9 S17 S21 S25 S36 S38 S40 S461 S463 S466 T486 S487 S626 S670 S690 S710 T712 S734 T779 S784 T795 T870 S899 S1020 S1083 T1090 S1099 S1183 S1217 S1227 S1259 S1280 S1283 S1297 Y1420 T1422 protein RNA SCNV methylation OV S9 S17 S21 S25 S36 S38 S40 S461 S463 S466 T486 S487 S626 S670 S690 S710 T712 S734 T779 S784 T795 T870 S899 S1020 S1083 T1090 S1099 S1183 S1217 S1227 S1259 S1280 S1283 S1297 Y1420 T1422 protein RNA SCNV methylation PDAC S9 S17 S21 S25 S36 S38 S40 S461 S463 S466 T486 S487 S626 S670 S690 S710 T712 S734 T779 S784 T795 T870 S899 S1020 S1083 T1090 S1099 S1183 S1217 S1227 S1259 S1280 S1283 S1297 Y1420 T1422 protein RNA SCNV methylation UCEC S9 S17 S21 S25 S36 S38 S40 S461 S463 S466 T486 S487 S626 S670 S690 S710 T712 S734 T779 S784 T795 T870 S899 S1020 S1083 T1090 S1099 S1183 S1217 S1227 S1259 S1280 S1283 S1297 Y1420 T1422 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S9
S17
S21
S25
S36
S38
S40
S461
S463
S466
T486
S487
S626
S670
S690
S710
T712
S734
T779
S784
T795
T870
S899
S1020
S1083
T1090
S1099
S1183
S1217
S1227
S1259
S1280
S1283
S1297
Y1420
T1422
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S9
S17
S21
S25
S36
S38
S40
S461
S463
S466
T486
S487
S626
S670
S690
S710
T712
S734
T779
S784
T795
T870
S899
S1020
S1083
T1090
S1099
S1183
S1217
S1227
S1259
S1280
S1283
S1297
Y1420
T1422
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.