ERBB2: erb-b2 receptor tyrosine kinase 2
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1mfg chain B
1mfl chain B
1mw4 chain B
1n8z chain C
1qr1 chain C
1qr1 chain F
1s78 chain A
1s78 chain B
2a91 chain A
2jwa chain A
2jwa chain B
2ks1 chain A
2l4k chain B
2n2a chain A
2n2a chain B
3be1 chain A
3h3b chain A
3h3b chain B
3mzw chain A
3n85 chain A
3pp0 chain A
3pp0 chain B
3rcd chain A
3rcd chain B
3rcd chain C
3rcd chain D
3wlw chain A
3wlw chain B
3wsq chain A
4gfu chain F
4hrl chain C
4hrm chain A
4hrm chain C
4hrn chain C
4hrn chain D
4nnd chain C
4nnd chain E
4nnd chain F
4nnd chain H
5k33 chain C
5kwg chain C
5my6 chain A
5o4g chain C
5ob4 chain A
5ob4 chain B
5tqs chain E
5tqs chain F
5tqs chain G
5tqs chain H
6att chain A
6bgt chain C
6j71 chain A
6lbx chain B
6oge chain A
7jxh chain A
7jxh chain B
7jxh chain C
7jxh chain D
7jxh chain E
7jxh chain F
7jxh chain G
7jxh chain H
7mn5 chain B
7mn6 chain B
7mn8 chain B
7pcd chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S573 ECQPQNGS VTCFGPE 1 9 - - 5 4 - - - - - - - - - - - - - - - - T575 QPQNGSVT CFGPEAD 1 9 - - 5 4 - - - - - - - - - - - - - - - - T701 TELVEPLT PSGAMPN 10 1488 113 - 103 80 92 87 90 - 108 62 93 85 110 101 83 19 105 44 95 18 S703 LVEPLTPS GAMPNQA 2 15 8 - - - - - - - - - - - - - - - 5 2 - - T759 IKVLRENT SPKANKE 1 40 40 - - - - - - - - - - - - - - - - - - - S819 ENRGRLGS QDLLNWC 5 207 38 - - - - - - - - - 24 21 57 51 - - 5 2 7 2 Y877 LDIDETEY HADGGKV 4 114 18 - - - - - - - 40 23 - - - - 7 1 - - 12 13 S998 NEDLGPAS PLDSTFY 10 1302 106 - 103 80 81 89 18 - 108 62 84 77 101 92 63 16 90 39 75 18 Y1023 DLVDAEEY LVPQQGF 1 7 7 - - - - - - - - - - - - - - - - - - - S1049 MVHHRHRS SSTRSGG 3 20 6 - 4 4 - - - - - - - - - - - - 5 1 - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S573 ECQPQNGS VTCFGPE - - - - - - - - - - - T575 QPQNGSVT CFGPEAD - - - - - - - - - - - T701 TELVEPLT PSGAMPN -1.8e-16 - -6.1e-3 -1.6e-17 - -1.7e-21 -1.2e-7 -0.19 -0.37 1.3e-5 0.53 S703 LVEPLTPS GAMPNQA - - - - - - - - - - - T759 IKVLRENT SPKANKE - - - - - - - - - - - S819 ENRGRLGS QDLLNWC 1.1e-7 - - - - - 0.041 4.8e-8 - - - Y877 LDIDETEY HADGGKV -2.7e-7 - - - - -2.7e-7 - - - - - S998 NEDLGPAS PLDSTFY -9.4e-16 - -8.4e-7 -1.4e-6 - -3.3e-20 -2.7e-9 -0.49 -0.33 2.9e-6 -0.41 Y1023 DLVDAEEY LVPQQGF - - - - - - - - - - - S1049 MVHHRHRS SSTRSGG - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S573
T575
T701
S703
T759
S819
Y877
S998
Y1023
S1049
S1050
S1051
T1052
S1054
T1060
S1066
S1073
S1078
S1083
S1100
S1107
S1122
T1124
Y1127
T1132
S1134
Y1139
S1151
T1166
S1174
T1240
T1242
Y1248
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S573 T575 T701 S703 T759 S819 Y877 S998 Y1023 S1049 S1050 S1051 T1052 S1054 T1060 S1066 S1073 S1078 S1083 S1100 S1107 S1122 T1124 Y1127 T1132 S1134 Y1139 S1151 T1166 S1174 T1240 T1242 Y1248 protein RNA SCNV methylation CCRCC S573 T575 T701 S703 T759 S819 Y877 S998 Y1023 S1049 S1050 S1051 T1052 S1054 T1060 S1066 S1073 S1078 S1083 S1100 S1107 S1122 T1124 Y1127 T1132 S1134 Y1139 S1151 T1166 S1174 T1240 T1242 Y1248 protein RNA SCNV methylation COAD S573 T575 T701 S703 T759 S819 Y877 S998 Y1023 S1049 S1050 S1051 T1052 S1054 T1060 S1066 S1073 S1078 S1083 S1100 S1107 S1122 T1124 Y1127 T1132 S1134 Y1139 S1151 T1166 S1174 T1240 T1242 Y1248 protein RNA SCNV methylation GBM S573 T575 T701 S703 T759 S819 Y877 S998 Y1023 S1049 S1050 S1051 T1052 S1054 T1060 S1066 S1073 S1078 S1083 S1100 S1107 S1122 T1124 Y1127 T1132 S1134 Y1139 S1151 T1166 S1174 T1240 T1242 Y1248 protein RNA SCNV methylation HNSCC S573 T575 T701 S703 T759 S819 Y877 S998 Y1023 S1049 S1050 S1051 T1052 S1054 T1060 S1066 S1073 S1078 S1083 S1100 S1107 S1122 T1124 Y1127 T1132 S1134 Y1139 S1151 T1166 S1174 T1240 T1242 Y1248 protein RNA SCNV methylation LSCC S573 T575 T701 S703 T759 S819 Y877 S998 Y1023 S1049 S1050 S1051 T1052 S1054 T1060 S1066 S1073 S1078 S1083 S1100 S1107 S1122 T1124 Y1127 T1132 S1134 Y1139 S1151 T1166 S1174 T1240 T1242 Y1248 protein RNA SCNV methylation LUAD S573 T575 T701 S703 T759 S819 Y877 S998 Y1023 S1049 S1050 S1051 T1052 S1054 T1060 S1066 S1073 S1078 S1083 S1100 S1107 S1122 T1124 Y1127 T1132 S1134 Y1139 S1151 T1166 S1174 T1240 T1242 Y1248 protein RNA SCNV methylation OV S573 T575 T701 S703 T759 S819 Y877 S998 Y1023 S1049 S1050 S1051 T1052 S1054 T1060 S1066 S1073 S1078 S1083 S1100 S1107 S1122 T1124 Y1127 T1132 S1134 Y1139 S1151 T1166 S1174 T1240 T1242 Y1248 protein RNA SCNV methylation PDAC S573 T575 T701 S703 T759 S819 Y877 S998 Y1023 S1049 S1050 S1051 T1052 S1054 T1060 S1066 S1073 S1078 S1083 S1100 S1107 S1122 T1124 Y1127 T1132 S1134 Y1139 S1151 T1166 S1174 T1240 T1242 Y1248 protein RNA SCNV methylation UCEC S573 T575 T701 S703 T759 S819 Y877 S998 Y1023 S1049 S1050 S1051 T1052 S1054 T1060 S1066 S1073 S1078 S1083 S1100 S1107 S1122 T1124 Y1127 T1132 S1134 Y1139 S1151 T1166 S1174 T1240 T1242 Y1248 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S573
T575
T701
S703
T759
S819
Y877
S998
Y1023
S1049
S1050
S1051
T1052
S1054
T1060
S1066
S1073
S1078
S1083
S1100
S1107
S1122
T1124
Y1127
T1132
S1134
Y1139
S1151
T1166
S1174
T1240
T1242
Y1248
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S573
T575
T701
S703
T759
S819
Y877
S998
Y1023
S1049
S1050
S1051
T1052
S1054
T1060
S1066
S1073
S1078
S1083
S1100
S1107
S1122
T1124
Y1127
T1132
S1134
Y1139
S1151
T1166
S1174
T1240
T1242
Y1248
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.