SETDB1: SET domain bifurcated histone lysine methyltransferase 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
3dlm chain A
4x3s chain C
4x3s chain D
5kch chain A
5kco chain A
5ke2 chain A
5ke3 chain A
5kh6 chain A
5qt1 chain A
5qt2 chain A
6au2 chain A
6au3 chain A
6bhd chain A
6bhe chain A
6bhg chain A
6bhh chain A
6bhi chain A
6bpi chain A
7c9n chain A
7c9n chain B
7caj chain A
7caj chain D
7cd9 chain A
7cd9 chain B
7cjt chain A
7cjt chain B
7cjt chain C
7cjt chain D
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S111 GLQYRDSS SEDESSR 1 8 8 - - - - - - - - - - - - - - - - - - - T120 EDESSRPT EIIEIPD 2 16 8 - - - - - - - - - 5 3 - - - - - - - - S134 DEDDDVLS IDSGDAG 1 6 - - - - - - - - - - - - - - - - - - 6 - S137 DDVLSIDS GDAGSRT 1 6 - - - - - - - - - - - - - - - - - - 6 - S176 DAVNKKSS SQDLHKG 5 169 - - - - - - 72 - - - 20 18 - - 15 3 22 7 12 - S177 AVNKKSSS QDLHKGT 1 9 - - - - - - 9 - - - - - - - - - - - - - S189 KGTLSQMS GELSKDG 2 23 - - - - - - - - - - - - 9 7 - - - - 5 2 S468 FPPAPPLS PQAGDSD 2 13 - - - - - - - - 5 2 - - - - - - - - 6 - S474 LSPQAGDS DLESQLA 1 6 - - - - - - - - - - - - - - - - - - 6 - S505 SVGSGHSS PTSPALS 1 26 - - - - - - - - - - - - - - 21 5 - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S111 GLQYRDSS SEDESSR - - - - - - - - - - - T120 EDESSRPT EIIEIPD - - - - - - - - - - - S134 DEDDDVLS IDSGDAG - - - - - - - - - - - S137 DDVLSIDS GDAGSRT - - - - - - - - - - - S176 DAVNKKSS SQDLHKG 1.7e-4 - - - - - 1.7e-4 - - - - S177 AVNKKSSS QDLHKGT - - - - - - - - - - - S189 KGTLSQMS GELSKDG - - - - - - - - - - - S468 FPPAPPLS PQAGDSD - - - - - - - - - - - S474 LSPQAGDS DLESQLA - - - - - - - - - - - S505 SVGSGHSS PTSPALS - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S111
T120
S134
S137
S176
S177
S189
S468
S474
S505
T507
Y526
S528
S532
T533
S535
S579
S862
S905
S906
S917
T943
S944
S991
S998
S1000
S1002
S1003
S1025
S1066
S1078
T1080
S1081
T1135
S1137
S1138
S1140
T1180
S1184
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S111 T120 S134 S137 S176 S177 S189 S468 S474 S505 T507 Y526 S528 S532 T533 S535 S579 S862 S905 S906 S917 T943 S944 S991 S998 S1000 S1002 S1003 S1025 S1066 S1078 T1080 S1081 T1135 S1137 S1138 S1140 T1180 S1184 protein RNA SCNV methylation CCRCC S111 T120 S134 S137 S176 S177 S189 S468 S474 S505 T507 Y526 S528 S532 T533 S535 S579 S862 S905 S906 S917 T943 S944 S991 S998 S1000 S1002 S1003 S1025 S1066 S1078 T1080 S1081 T1135 S1137 S1138 S1140 T1180 S1184 protein RNA SCNV methylation COAD S111 T120 S134 S137 S176 S177 S189 S468 S474 S505 T507 Y526 S528 S532 T533 S535 S579 S862 S905 S906 S917 T943 S944 S991 S998 S1000 S1002 S1003 S1025 S1066 S1078 T1080 S1081 T1135 S1137 S1138 S1140 T1180 S1184 protein RNA SCNV methylation GBM S111 T120 S134 S137 S176 S177 S189 S468 S474 S505 T507 Y526 S528 S532 T533 S535 S579 S862 S905 S906 S917 T943 S944 S991 S998 S1000 S1002 S1003 S1025 S1066 S1078 T1080 S1081 T1135 S1137 S1138 S1140 T1180 S1184 protein RNA SCNV methylation HNSCC S111 T120 S134 S137 S176 S177 S189 S468 S474 S505 T507 Y526 S528 S532 T533 S535 S579 S862 S905 S906 S917 T943 S944 S991 S998 S1000 S1002 S1003 S1025 S1066 S1078 T1080 S1081 T1135 S1137 S1138 S1140 T1180 S1184 protein RNA SCNV methylation LSCC S111 T120 S134 S137 S176 S177 S189 S468 S474 S505 T507 Y526 S528 S532 T533 S535 S579 S862 S905 S906 S917 T943 S944 S991 S998 S1000 S1002 S1003 S1025 S1066 S1078 T1080 S1081 T1135 S1137 S1138 S1140 T1180 S1184 protein RNA SCNV methylation LUAD S111 T120 S134 S137 S176 S177 S189 S468 S474 S505 T507 Y526 S528 S532 T533 S535 S579 S862 S905 S906 S917 T943 S944 S991 S998 S1000 S1002 S1003 S1025 S1066 S1078 T1080 S1081 T1135 S1137 S1138 S1140 T1180 S1184 protein RNA SCNV methylation OV S111 T120 S134 S137 S176 S177 S189 S468 S474 S505 T507 Y526 S528 S532 T533 S535 S579 S862 S905 S906 S917 T943 S944 S991 S998 S1000 S1002 S1003 S1025 S1066 S1078 T1080 S1081 T1135 S1137 S1138 S1140 T1180 S1184 protein RNA SCNV methylation PDAC S111 T120 S134 S137 S176 S177 S189 S468 S474 S505 T507 Y526 S528 S532 T533 S535 S579 S862 S905 S906 S917 T943 S944 S991 S998 S1000 S1002 S1003 S1025 S1066 S1078 T1080 S1081 T1135 S1137 S1138 S1140 T1180 S1184 protein RNA SCNV methylation UCEC S111 T120 S134 S137 S176 S177 S189 S468 S474 S505 T507 Y526 S528 S532 T533 S535 S579 S862 S905 S906 S917 T943 S944 S991 S998 S1000 S1002 S1003 S1025 S1066 S1078 T1080 S1081 T1135 S1137 S1138 S1140 T1180 S1184 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S111
T120
S134
S137
S176
S177
S189
S468
S474
S505
T507
Y526
S528
S532
T533
S535
S579
S862
S905
S906
S917
T943
S944
S991
S998
S1000
S1002
S1003
S1025
S1066
S1078
T1080
S1081
T1135
S1137
S1138
S1140
T1180
S1184
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S111
T120
S134
S137
S176
S177
S189
S468
S474
S505
T507
Y526
S528
S532
T533
S535
S579
S862
S905
S906
S917
T943
S944
S991
S998
S1000
S1002
S1003
S1025
S1066
S1078
T1080
S1081
T1135
S1137
S1138
S1140
T1180
S1184
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.