EGFR:
epidermal growth factor receptor

Lollipop plot

Phosphosites location and occurrence

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Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S151LHGAVRFSNNPALCN19------9-------------
S177SDFLSNMSMDFQNHL19------9-------------
S315VRACGADSYEMEEDG172------72-------------
T483NWKKLFGTSGQKTKI251----45--------357----
S484WKKLFGTSGQKTKII251----45--------357----
T693RELVEPLTPSGEAPN101509104-103809710099-108621089810597791996419518
S695LVEPLTPSGEAPNQA6192--98--98-5415131816----6-
Y869LGAEEKEYHAEGGKV110----------55--------
S991DERMHLPSPTDSNFY10136538-10380727299-1086210899110101681780359518
T993RMHLPSPTDSNFYRA4131--44----281525211816------
Showing 1 to 10 of 48 rows
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Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S151LHGAVRFSNNPALCN-----------
S177SDFLSNMSMDFQNHL-----------
S315VRACGADSYEMEEDG-----------
T483NWKKLFGTSGQKTKI-----------
S484WKKLFGTSGQKTKII-----------
T693RELVEPLTPSGEAPN-1.8e-3-1.2e-21-4.9e-27--0.320.44-3.4e-3-1.2e-61.3e-8-7.3e-5
S695LVEPLTPSGEAPNQA-----------
Y869LGAEEKEYHAEGGKV-----------
S991DERMHLPSPTDSNFY0.084-1.1e-10-7.3e-13-1.0e-5-0.8-0.98-4.9e-44.6e-40.14
T993RMHLPSPTDSNFYRA-5.1e-3-----1.9e-3-0.39----
Showing 1 to 10 of 48 rows
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS151S177S315T483S484T693S695Y869S991T993S995Y998Y1016S1025S1026S1028S1030S1036S1037S1039T1041S1042S1045T1046S1057S1064Y1069S1070S1071T1078S1081T1085Y1092S1096S1104Y1110Y1125Y1138T1145S1153S1162S1166Y1172S1190T1191Y1197S1204S1205proteinRNASCNVmethylationCCRCCS151S177S315T483S484T693S695Y869S991T993S995Y998Y1016S1025S1026S1028S1030S1036S1037S1039T1041S1042S1045T1046S1057S1064Y1069S1070S1071T1078S1081T1085Y1092S1096S1104Y1110Y1125Y1138T1145S1153S1162S1166Y1172S1190T1191Y1197S1204S1205proteinRNASCNVmethylationCOADS151S177S315T483S484T693S695Y869S991T993S995Y998Y1016S1025S1026S1028S1030S1036S1037S1039T1041S1042S1045T1046S1057S1064Y1069S1070S1071T1078S1081T1085Y1092S1096S1104Y1110Y1125Y1138T1145S1153S1162S1166Y1172S1190T1191Y1197S1204S1205proteinRNASCNVmethylationGBMS151S177S315T483S484T693S695Y869S991T993S995Y998Y1016S1025S1026S1028S1030S1036S1037S1039T1041S1042S1045T1046S1057S1064Y1069S1070S1071T1078S1081T1085Y1092S1096S1104Y1110Y1125Y1138T1145S1153S1162S1166Y1172S1190T1191Y1197S1204S1205proteinRNASCNVmethylationHNSCCS151S177S315T483S484T693S695Y869S991T993S995Y998Y1016S1025S1026S1028S1030S1036S1037S1039T1041S1042S1045T1046S1057S1064Y1069S1070S1071T1078S1081T1085Y1092S1096S1104Y1110Y1125Y1138T1145S1153S1162S1166Y1172S1190T1191Y1197S1204S1205proteinRNASCNVmethylationLSCCS151S177S315T483S484T693S695Y869S991T993S995Y998Y1016S1025S1026S1028S1030S1036S1037S1039T1041S1042S1045T1046S1057S1064Y1069S1070S1071T1078S1081T1085Y1092S1096S1104Y1110Y1125Y1138T1145S1153S1162S1166Y1172S1190T1191Y1197S1204S1205proteinRNASCNVmethylationLUADS151S177S315T483S484T693S695Y869S991T993S995Y998Y1016S1025S1026S1028S1030S1036S1037S1039T1041S1042S1045T1046S1057S1064Y1069S1070S1071T1078S1081T1085Y1092S1096S1104Y1110Y1125Y1138T1145S1153S1162S1166Y1172S1190T1191Y1197S1204S1205proteinRNASCNVmethylationOVS151S177S315T483S484T693S695Y869S991T993S995Y998Y1016S1025S1026S1028S1030S1036S1037S1039T1041S1042S1045T1046S1057S1064Y1069S1070S1071T1078S1081T1085Y1092S1096S1104Y1110Y1125Y1138T1145S1153S1162S1166Y1172S1190T1191Y1197S1204S1205proteinRNASCNVmethylationPDACS151S177S315T483S484T693S695Y869S991T993S995Y998Y1016S1025S1026S1028S1030S1036S1037S1039T1041S1042S1045T1046S1057S1064Y1069S1070S1071T1078S1081T1085Y1092S1096S1104Y1110Y1125Y1138T1145S1153S1162S1166Y1172S1190T1191Y1197S1204S1205proteinRNASCNVmethylationUCECS151S177S315T483S484T693S695Y869S991T993S995Y998Y1016S1025S1026S1028S1030S1036S1037S1039T1041S1042S1045T1046S1057S1064Y1069S1070S1071T1078S1081T1085Y1092S1096S1104Y1110Y1125Y1138T1145S1153S1162S1166Y1172S1190T1191Y1197S1204S1205proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.