DLC1: DLC1 Rho GTPase activating protein
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2dky chain A
2gyt chain A
2kap chain A
2loz chain B
3kuq chain A
5fzt chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S354 RDRARLDS MVLLIMK 3 59 - - 22 12 - - - - 5 3 - - 8 9 - - - - - - S374 QDIENALS TSSSPSG 4 48 6 - 8 8 - - - - - - 10 9 - - 6 1 - - - - T375 DIENALST SSSPSGT 2 22 8 - 8 6 - - - - - - - - - - - - - - - - S378 NALSTSSS PSGTPTN 3 28 - - - - 5 4 - - - - - - - - - - 8 3 5 3 S395 RHVPDLES GSESGAD 2 35 15 - - - - - - - - - 10 10 - - - - - - - - S397 VPDLESGS ESGADTI 3 44 15 - - - - - - - - - 10 10 - - - - - - - 9 S415 QTRVNLSS DTESTDL 3 31 13 - - - - - - - 5 3 5 5 - - - - - - - - T417 RVNLSSDT ESTDLPS 1 8 - - 4 4 - - - - - - - - - - - - - - - - S517 AVMKLEIS PHRKRSD 4 93 - - - - - - 9 - - - 20 20 15 12 14 3 - - - - S523 ISPHRKRS DDSDEDE 8 797 105 - 103 80 83 87 99 - 49 32 10 9 4 4 - - 94 38 - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S354 RDRARLDS MVLLIMK -0.34 - -0.34 - - - - - - - - S374 QDIENALS TSSSPSG - - - - - - - - - - - T375 DIENALST SSSPSGT - - - - - - - - - - - S378 NALSTSSS PSGTPTN - - - - - - - - - - - S395 RHVPDLES GSESGAD - - - - - - - - - - - S397 VPDLESGS ESGADTI - - - - - - - - - - - S415 QTRVNLSS DTESTDL - - - - - - - - - - - T417 RVNLSSDT ESTDLPS - - - - - - - - - - - S517 AVMKLEIS PHRKRSD -2.8e-9 - - - - - -2.8e-9 - - - - S523 ISPHRKRS DDSDEDE -2.4e-14 - -1.2e-15 -0.53 - -9.6e-11 - - - -0.87 -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S354
S374
T375
S378
S395
S397
S415
T417
S517
S523
S526
S535
S544
S548
S557
S566
S577
T600
S602
S605
S620
S626
S642
S652
S733
S735
S764
S766
S800
Y801
S828
S830
S835
T840
S842
S850
S856
S868
S869
S928
S933
S935
S939
S945
S946
S962
S970
S978
S986
S1254
S1296
Y1297
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S354 S374 T375 S378 S395 S397 S415 T417 S517 S523 S526 S535 S544 S548 S557 S566 S577 T600 S602 S605 S620 S626 S642 S652 S733 S735 S764 S766 S800 Y801 S828 S830 S835 T840 S842 S850 S856 S868 S869 S928 S933 S935 S939 S945 S946 S962 S970 S978 S986 S1254 S1296 Y1297 protein RNA SCNV methylation CCRCC S354 S374 T375 S378 S395 S397 S415 T417 S517 S523 S526 S535 S544 S548 S557 S566 S577 T600 S602 S605 S620 S626 S642 S652 S733 S735 S764 S766 S800 Y801 S828 S830 S835 T840 S842 S850 S856 S868 S869 S928 S933 S935 S939 S945 S946 S962 S970 S978 S986 S1254 S1296 Y1297 protein RNA SCNV methylation COAD S354 S374 T375 S378 S395 S397 S415 T417 S517 S523 S526 S535 S544 S548 S557 S566 S577 T600 S602 S605 S620 S626 S642 S652 S733 S735 S764 S766 S800 Y801 S828 S830 S835 T840 S842 S850 S856 S868 S869 S928 S933 S935 S939 S945 S946 S962 S970 S978 S986 S1254 S1296 Y1297 protein RNA SCNV methylation GBM S354 S374 T375 S378 S395 S397 S415 T417 S517 S523 S526 S535 S544 S548 S557 S566 S577 T600 S602 S605 S620 S626 S642 S652 S733 S735 S764 S766 S800 Y801 S828 S830 S835 T840 S842 S850 S856 S868 S869 S928 S933 S935 S939 S945 S946 S962 S970 S978 S986 S1254 S1296 Y1297 protein RNA SCNV methylation HNSCC S354 S374 T375 S378 S395 S397 S415 T417 S517 S523 S526 S535 S544 S548 S557 S566 S577 T600 S602 S605 S620 S626 S642 S652 S733 S735 S764 S766 S800 Y801 S828 S830 S835 T840 S842 S850 S856 S868 S869 S928 S933 S935 S939 S945 S946 S962 S970 S978 S986 S1254 S1296 Y1297 protein RNA SCNV methylation LSCC S354 S374 T375 S378 S395 S397 S415 T417 S517 S523 S526 S535 S544 S548 S557 S566 S577 T600 S602 S605 S620 S626 S642 S652 S733 S735 S764 S766 S800 Y801 S828 S830 S835 T840 S842 S850 S856 S868 S869 S928 S933 S935 S939 S945 S946 S962 S970 S978 S986 S1254 S1296 Y1297 protein RNA SCNV methylation LUAD S354 S374 T375 S378 S395 S397 S415 T417 S517 S523 S526 S535 S544 S548 S557 S566 S577 T600 S602 S605 S620 S626 S642 S652 S733 S735 S764 S766 S800 Y801 S828 S830 S835 T840 S842 S850 S856 S868 S869 S928 S933 S935 S939 S945 S946 S962 S970 S978 S986 S1254 S1296 Y1297 protein RNA SCNV methylation OV S354 S374 T375 S378 S395 S397 S415 T417 S517 S523 S526 S535 S544 S548 S557 S566 S577 T600 S602 S605 S620 S626 S642 S652 S733 S735 S764 S766 S800 Y801 S828 S830 S835 T840 S842 S850 S856 S868 S869 S928 S933 S935 S939 S945 S946 S962 S970 S978 S986 S1254 S1296 Y1297 protein RNA SCNV methylation PDAC S354 S374 T375 S378 S395 S397 S415 T417 S517 S523 S526 S535 S544 S548 S557 S566 S577 T600 S602 S605 S620 S626 S642 S652 S733 S735 S764 S766 S800 Y801 S828 S830 S835 T840 S842 S850 S856 S868 S869 S928 S933 S935 S939 S945 S946 S962 S970 S978 S986 S1254 S1296 Y1297 protein RNA SCNV methylation UCEC S354 S374 T375 S378 S395 S397 S415 T417 S517 S523 S526 S535 S544 S548 S557 S566 S577 T600 S602 S605 S620 S626 S642 S652 S733 S735 S764 S766 S800 Y801 S828 S830 S835 T840 S842 S850 S856 S868 S869 S928 S933 S935 S939 S945 S946 S962 S970 S978 S986 S1254 S1296 Y1297 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S354
S374
T375
S378
S395
S397
S415
T417
S517
S523
S526
S535
S544
S548
S557
S566
S577
T600
S602
S605
S620
S626
S642
S652
S733
S735
S764
S766
S800
Y801
S828
S830
S835
T840
S842
S850
S856
S868
S869
S928
S933
S935
S939
S945
S946
S962
S970
S978
S986
S1254
S1296
Y1297
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S354
S374
T375
S378
S395
S397
S415
T417
S517
S523
S526
S535
S544
S548
S557
S566
S577
T600
S602
S605
S620
S626
S642
S652
S733
S735
S764
S766
S800
Y801
S828
S830
S835
T840
S842
S850
S856
S868
S869
S928
S933
S935
S939
S945
S946
S962
S970
S978
S986
S1254
S1296
Y1297
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.