Protein: ENSP00000280377
Gene: USP15

LinkedOmicsKB © 2022-2023 Zhang Lab

USP15:
ubiquitin specific peptidase 15

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S49KKYVGFDSWDKYQMG736416-1716--54-241255524946----194
S78LKDGDAQSLKEHLID867021-6455--72-261958546659--9339422
S170KEIRKIFSIPDEKET6213------9-221535313836--52173
T226TWPRGPSTPKSPGAS84069---252845-6473673328--5120134
S229RGPSTPKSPGASNFS10129265-65539710099-10359746784767717101429518
S233TPKSPGASNFSTLPK16------------------6-
S242FSTLPKISPSSLSNN92307---4571-116151454721054915
S245LPKISPSSLSNNYNN16--42----------------
S630ETEETEGSLHCCKDQ948966-5411727-40234845827671--2918
S961ATGIPLESDEDSNDN965173-6548101463-603538354137--2198418
Showing 1 to 10 of 11 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S49KKYVGFDSWDKYQMG-2.2e-29-----0.005-1.2e-15-3.9e-18---
S78LKDGDAQSLKEHLID-7.2e-20-0.21--0.79-5.9e-16-5.1e-18--2.1e-7-
S170KEIRKIFSIPDEKET-0.097----0.35-0.96-1.7e-4---
T226TWPRGPSTPKSPGAS0.075--1.8e-4--0.015-0.2--0.18-
S229RGPSTPKSPGASNFS-1-7.4e-37.6e-9--0.0520.033-4.3e-3-1.3e-4-1e-111.3e-6
S233TPKSPGASNFSTLPK-----------
S242FSTLPKISPSSLSNN0.013---------0.013
S245LPKISPSSLSNNYNN-----------
S630ETEETEGSLHCCKDQ2.6e-27----1.1e-94.5e-71.6e-10--3.8e-5
S961ATGIPLESDEDSNDN-9.1e-3--2.1e-3---0.0470.840.035---0.002
Showing 1 to 10 of 11 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS49S78S170T226S229S233S242S245S630S961S965proteinRNASCNVmethylationCCRCCS49S78S170T226S229S233S242S245S630S961S965proteinRNASCNVmethylationCOADS49S78S170T226S229S233S242S245S630S961S965proteinRNASCNVmethylationGBMS49S78S170T226S229S233S242S245S630S961S965proteinRNASCNVmethylationHNSCCS49S78S170T226S229S233S242S245S630S961S965proteinRNASCNVmethylationLSCCS49S78S170T226S229S233S242S245S630S961S965proteinRNASCNVmethylationLUADS49S78S170T226S229S233S242S245S630S961S965proteinRNASCNVmethylationOVS49S78S170T226S229S233S242S245S630S961S965proteinRNASCNVmethylationPDACS49S78S170T226S229S233S242S245S630S961S965proteinRNASCNVmethylationUCECS49S78S170T226S229S233S242S245S630S961S965proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.